Pharmacological Inhibition of EZH2 by ZLD1039 Suppresses Tumor Growth and Pulmonary Metastasis in Melanoma Cells in vitro and in vivo.
暂无分享,去创建一个
Lidan Zhang | Yongxia Zhu | Xuejiao Song | Luoting Yu | Hongtao Xiao | Qiangsheng Zhang | Ting Wang | Luoting Yu
[1] J. Burke,et al. Taking the EZ way: Targeting enhancer of zeste homolog 2 in B-cell lymphomas. , 2022, Blood reviews.
[2] Chengyuan Liang,et al. Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors: Candidate Structure-Activity Relationships Insights and Evolution Prospects. , 2022, Journal of medicinal chemistry.
[3] S. Wen,et al. Design and Synthesis of Dual EZH2/BRD4 Inhibitors to Target Solid Tumors. , 2022, Journal of medicinal chemistry.
[4] A. Lallas,et al. European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022. , 2022, European journal of cancer.
[5] D. Hanahan. Hallmarks of Cancer: New Dimensions. , 2022, Cancer discovery.
[6] Chunying Li,et al. Signal pathways of melanoma and targeted therapy , 2021, Signal Transduction and Targeted Therapy.
[7] B. Teicher,et al. Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies , 2021, Laboratory Investigation.
[8] W. De,et al. EZH2-mediated epigenetic suppression of lncRNA PCAT18 predicts a poor prognosis and regulates the expression of p16 by interacting with miR-570a-3p in gastric cancer , 2021, Journal of Cancer.
[9] A. Mai,et al. Polycomb Repressive Complex 2 Modulation through the Development of EZH2–EED Interaction Inhibitors and EED Binders , 2021, Journal of medicinal chemistry.
[10] Peng Huang,et al. Design, Synthesis, and Evaluation of VHL-Based EZH2 Degraders to Enhance Therapeutic Activity against Lymphoma. , 2021, Journal of medicinal chemistry.
[11] Kaixian Chen,et al. Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. , 2021, Journal of medicinal chemistry.
[12] Lidan Zhang,et al. The discovery of SKLB-0335 as a paralog-selective EZH2 covalent inhibitor. , 2021, Chemical communications.
[13] Xiuli Wu,et al. Design and Synthesis of EZH2-Based PROTACs to Degrade the Complex for Targeting the Noncatalytic Activity of EZH2. , 2021, Journal of medicinal chemistry.
[14] A. Jemal,et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries , 2021, CA: a cancer journal for clinicians.
[15] K. Flaherty,et al. Cobimetinib plus atezolizumab in BRAFV600 wild-type melanoma: primary results from the randomized phase 3 IMspire170 study. , 2020, Annals of oncology : official journal of the European Society for Medical Oncology.
[16] S. Stacchiotti,et al. Tazemetostat for advanced epithelioid sarcoma: current status and future perspectives. , 2020, Future oncology.
[17] Yong Xia,et al. Repurposing of Antipsychotic Trifluoperazine for Treating Brain Metastasis, Lung Metastasis and Bone Metastasis of Melanoma by Disrupting Autophagy Flux. , 2020, Pharmacological research.
[18] Clare Gregson,et al. Targeting PRC2 for the treatment of cancer: an updated patent review (2016 - 2020) , 2020, Expert opinion on therapeutic patents.
[19] Z. Werb,et al. Concepts of extracellular matrix remodelling in tumour progression and metastasis , 2020, Nature Communications.
[20] G. Salles,et al. Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial. , 2020, The Lancet. Oncology.
[21] S. Shiva,et al. Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement , 2020, Redox biology.
[22] K. Tew,et al. Oxidative Stress in Cancer. , 2020, Cancer cell.
[23] Sheridan M. Hoy. Tazemetostat: First Approval , 2020, Drugs.
[24] Friederike Hoffmann,et al. H3K27me3 and EZH2 expression in melanoma: relevance for melanoma progression and response to immune checkpoint blockade , 2020, Clinical Epigenetics.
[25] A. Laganà,et al. Discovery of a first-in-class EZH2 selective degrader , 2019, Nature Chemical Biology.
[26] Xiuli Wu,et al. Repurposing of the Anti-helminthic Drug Niclosamide to Treat Melanoma and Pulmonary Metastasis via the STAT3 Signaling Pathway. , 2019, Biochemical pharmacology.
[27] R. Sullivan,et al. Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients , 2019, Nature Medicine.
[28] A. Vincent-Salomon,et al. EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer , 2019, Proceedings of the National Academy of Sciences.
[29] E. Jordanova,et al. Overexpression of EZH2 in conjunctival melanoma offers a new therapeutic target , 2018, The Journal of pathology.
[30] Liang-Chih Liu,et al. EZH2 promotes migration and invasion of triple-negative breast cancer cells via regulating TIMP2-MMP-2/-9 pathway. , 2018, American journal of cancer research.
[31] Jing Cai,et al. EZH2-mediated epigenetic silencing of TIMP2 promotes ovarian cancer migration and invasion , 2017, Scientific Reports.
[32] Ming Yan,et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP‐mediated ubiquitination , 2017, The EMBO journal.
[33] I. Makhoul,et al. Role of EZH2 histone methyltrasferase in melanoma progression and metastasis , 2016, Cancer biology & therapy.
[34] Yuquan Wei,et al. Selective inhibition of EZH2 by ZLD1039 blocks H3K27methylation and leads to potent anti-tumor activity in breast cancer , 2016, Scientific Reports.
[35] C. Roberts,et al. Targeting EZH2 in cancer , 2016, Nature Medicine.
[36] Nathan L. Avaritt,et al. Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma* , 2015, Molecular & Cellular Proteomics.
[37] T. Horvath,et al. Mitochondrial ROS Signaling in Organismal Homeostasis , 2015, Cell.
[38] Lidan Zhang,et al. Design, synthesis and biological evaluation of novel 1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolins as potential EZH2 inhibitors , 2015 .
[39] R. Dummer,et al. The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors , 2015, Nature Communications.
[40] P. Hersey,et al. EZH2: an emerging role in melanoma biology and strategies for targeted therapy , 2015, Pigment cell & melanoma research.
[41] D. Fisher,et al. The melanoma revolution: From UV carcinogenesis to a new era in therapeutics , 2014, Science.
[42] P. Schumacker,et al. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? , 2014, Nature Reviews Cancer.
[43] Yasunori Sato,et al. Immunostaining for Polycomb Group Protein EZH2 and Senescent Marker p16INK4a May Be Useful to Differentiate Cholangiolocellular Carcinoma From Ductular Reaction and Bile Duct Adenoma , 2014, The American journal of surgical pathology.
[44] Y. Sakamoto,et al. Enhancer of Zeste Homolog 2 (EZH2) Promotes Progression of Cholangiocarcinoma Cells by Regulating Cell Cycle and Apoptosis , 2013, Annals of Surgical Oncology.
[45] Y. Wan,et al. H3K9me-enhanced DNA hypermethylation of the p16INK4a gene: an epigenetic signature for spontaneous transformation of rat mesenchymal stem cells. , 2013, Stem cells and development.
[46] A. Sivachenko,et al. A Landscape of Driver Mutations in Melanoma , 2012, Cell.
[47] Benjamin E. Gross,et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. , 2012, Cancer discovery.
[48] Norma I Rodríguez-Malavé,et al. MicroRNAs in B cell development and malignancy , 2012, Journal of Hematology & Oncology.
[49] Yong Jiang,et al. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27) , 2012, Proceedings of the National Academy of Sciences.
[50] D. Reinberg,et al. The Polycomb complex PRC2 and its mark in life , 2011, Nature.
[51] J. Massagué,et al. G1 cell-cycle control and cancer , 2004, Nature.
[52] A. Hauschild,et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. , 2015, The New England journal of medicine.