Olfactory recognition: a simple memory system.

Mice have an olfactory (pheromone) recognition memory located at the first relay in the sensory system. It is acquired with one-trial learning, contingent upon norepinephrine activation at mating, and lasts for several weeks. The mechanism involves Hebbian (association-dependent) changes in synaptic efficacy at dendrodendritic synapses in the accessory olfactory bulb. As a result of this memory, males made familiar by mating are recognized by the females, thereby mitigating pregnancy block. Such a memory function is biologically important to the female, as it is required to sustain pregnancy in the presence of her stud male's odors.

[1]  H. M. Bruce.  A block to pregnancy in the mouse caused by proximity of strange males. , 1960, Journal of reproduction and fertility.

[2]  A. S. Parkes,et al.  Pregnancy-block in female mice placed in boxes soiled by males. , 1962, Journal of reproduction and fertility.

[3]  C. Dominic.  OBSERVATIONS ON THE REPRODUCTIVE PHEROMONES OF MICE , 1966 .

[4]  H. M. Bruce.  Absence of pregnancy-block in mice when stud and test males belong to an inbred strain. , 1968, Journal of reproduction and fertility.

[5]  C. Leonard,et al.  Origin and distribution of the amygdalofugal pathways in the rat: An experimental neuronatomical study , 1971 .

[6]  J. D. Olmos,et al.  The projection field of the stria terminalis in the rat brain. An experimental study , 1972, The Journal of comparative neurology.

[7]  T. Bliss,et al.  Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path , 1973, The Journal of physiology.

[8]  S. S. Winans,et al.  The differential projections of the olfactory bulb and accessory olfactory bulb in mammals , 1975, The Journal of comparative neurology.

[9]  E. Keverne,et al.  The accessory olfactory system and its role in the pheromonally mediated suppression of oestrus in grouped mice. , 1979, Journal of reproduction and fertility.

[10]  F. Bronson,et al.  The Reproductive Ecology of the House Mouse , 1979, The Quarterly Review of Biology.

[11]  E. Keverne,et al.  Involvement of the vomeronasal organ and prolactin in pheromonal induction of delayed implantation in mice. , 1980, Journal of reproduction and fertility.

[12]  L. Squire,et al.  Preserved learning and retention of pattern-analyzing skill in amnesia: dissociation of knowing how and knowing that. , 1980, Science.

[13]  N. Schwartz,et al.  Changes in serum hormone levels associated with male-induced ovulation in group-housed adult female mice. , 1980, Endocrinology.

[14]  J. Labov.  Pregnancy Blocking in Rodents: Adaptive Advantages for Females , 1981, The American Naturalist.

[15]  E. Keverne,et al.  Role of the brain and accessory olfactory system in the block to pregnancy in mice , 1982, Neuroscience.

[16]  U. Huck,et al.  Infanticide in male laboratory mice: Effects of social status, prior sexual experience, and basis for discrimination between related and unrelated young , 1982, Animal Behaviour.

[17]  E. Keverne,et al.  Role of the vomeronasal organ and prolactin in the acceleration of puberty in female mice. , 1982, Journal of reproduction and fertility.

[18]  T. Bliss,et al.  Reduction of long‐term potentiation in the dentate gyrus of the rat following selective depletion of monoamines. , 1983, The Journal of physiology.

[19]  G. Shepherd,et al.  Neurochemistry of the vertebrate olfactory bulb , 1983, Neuroscience.

[20]  Eric B. Keveme.  Pheromonal influences on the endocrine regulation of reproduction , 1983, Trends in Neurosciences.

[21]  G. Lynch,et al.  Hippocampal denervation causes rapid forgetting of olfactory information in rats. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[22]  D. Johnston,et al.  Frequency-dependent noradrenergic modulation of long-term potentiation in the hippocampus. , 1984, Science.

[23]  E. Keverne,et al.  The importance of central noradrenergic neurones in the formation of an olfactory memory in the prevention of pregnancy block , 1985, Neuroscience.

[24]  J. Coyle,et al.  N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[25]  M. T. Shipley,et al.  Surprisingly rich projection from locus coeruleus to the olfactory bulb in the rat , 1985, Brain Research.

[26]  J. E. Skinner,et al.  Chemical dependencies of learning in the rabbit olfactory bulb: acquisition of the transient spatial pattern change depends on norepinephrine. , 1986, Behavioral neuroscience.

[27]  C. Cotman,et al.  Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl d-aspartate antagonists , 1986, Neuroscience Letters.

[28]  M. Gutnick,et al.  An N-methyl-d-aspartate (NMDA) receptor antagonist reduces bicuculline-induced depolarization shifts in neocortical explant cultures , 1986, Neuroscience Letters.

[29]  G. Lynch,et al.  Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5 , 1986, Nature.

[30]  M. Leon.  Plasticity of olfactory output circuits related to early olfactory learning , 1987, Trends in Neurosciences.

[31]  R. Gervais.  Local GABAergic modulation of noradrenaline release in the rat olfactory bulb measured on superfused slices , 1987, Brain Research.

[32]  K. Mori.  Membrane and synaptic properties of identified neurons in the olfactory bulb , 1987, Progress in Neurobiology.

[33]  J. Coyle,et al.  Selective immunocytochemical staining of mitral cells in rat olfactory bulb with affinity purified antibodies against N-acetyl-aspartyl-glutamate , 1987, Brain Research.

[34]  W. Singer,et al.  Long-term potentiation and NMDA receptors in rat visual cortex , 1987, Nature.

[35]  D. Wilson,et al.  Noradrenergic modulation of olfactory bulb excitability in the postnatal rat. , 1988, Brain research.

[36]  H. Kaba,et al.  Hormonal enhancement of neurogenesis and its relationship to the duration of olfactory memory , 1988, Neuroscience.

[37]  E. W. Kairiss,et al.  Long-term synaptic potentiation. , 1988, Science.

[38]  G. Horn,et al.  Learning and memory: regional changes in N-methyl-D-aspartate receptors in the chick brain after imprinting. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[39]  G. Lynch,et al.  Contributions of quisqualate and NMDA receptors to the induction and expression of LTP. , 1988, Science.

[40]  R. Nicoll,et al.  NMDA application potentiates synaptic transmission in the hippocampus , 1988, Nature.

[41]  H. Kaba,et al.  The effect of microinfusions of drugs into the accessory olfactory bulb on the olfactory block to pregnancy , 1988, Neuroscience.

[42]  P. Brennan,et al.  Impairment of olfactory memory by local infusions of non-selective excitatory amino acid receptor antagonists into the accessory olfactory bulb , 1989, Neuroscience.

[43]  H. Kaba,et al.  Neural basis of olfactory memory in the context of pregnancy block , 1989, Neuroscience.

[44]  Graham L. Collingridge,et al.  Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation , 1989, Nature.

[45]  H. Kaba,et al.  Excitatory influence of the accessory olfactory bulb on tuberoinfundibular arcuate neurons of female mice and its modulation by oestrogen , 1989, Neuroscience.

[46]  E. Keverne,et al.  Hippocampal lesions are without effect on olfactory memory formation in the context of pregnancy block , 1990, Physiology & Behavior.