Edgotype: a fundamental link between genotype and phenotype.

[1]  R. Liddington.  Structural basis of protein-protein interactions. , 2015, Methods in molecular biology.

[2]  M. Vidal,et al.  Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma , 2014, Oncogene.

[3]  Andrew G. Clark,et al.  Distilling Pathophysiology from Complex Disease Genetics , 2013, Cell.

[4]  A. Clark,et al.  Dissecting disease inheritance modes in a three-dimensional protein network challenges the "guilt-by-association" principle. , 2013, American journal of human genetics.

[5]  A. Flenniken,et al.  ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice , 2013, PLoS genetics.

[6]  A. Ferrando,et al.  The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability , 2013, Cell.

[7]  Brian J. Stevenson,et al.  FAM111A mutations result in hypoparathyroidism and impaired skeletal development. , 2013, American journal of human genetics.

[8]  Minoru Yoshida,et al.  Cross-Species Protein Interactome Mapping Reveals Species-Specific Wiring of Stress Response Pathways , 2013, Science Signaling.

[9]  J. LaBaer,et al.  High‐throughput cloning and expression library creation for functional proteomics , 2013, Proteomics.

[10]  Ruedi Aebersold,et al.  Mass spectrometry supported determination of protein complex structure. , 2013, Current opinion in structural biology.

[11]  Giulio Superti-Furga,et al.  Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS , 2013, Nature Methods.

[12]  Ben Lehner.  Genotype to phenotype: lessons from model organisms for human genetics , 2013, Nature Reviews Genetics.

[13]  L. Furlong.  Human diseases through the lens of network biology. , 2013, Trends in genetics : TIG.

[14]  P. Howley,et al.  Proteomic approaches to the study of papillomavirus-host interactions. , 2013, Virology.

[15]  Ruth Nussinov,et al.  Structure and dynamics of molecular networks: A novel paradigm of drug discovery. A comprehensive review , 2012, Pharmacology & therapeutics.

[16]  Marc Vidal,et al.  Identification of FAM111A as an SV40 Host Range Restriction and Adenovirus Helper Factor , 2012, PLoS pathogens.

[17]  A. Gingras,et al.  Beyond hairballs: The use of quantitative mass spectrometry data to understand protein–protein interactions , 2012, FEBS letters.

[18]  K. Hogue,et al.  Mutant p53 interactome identifies nardilysin as a p53R273H‐specific binding partner that promotes invasion , 2012, EMBO reports.

[19]  Rahul C. Deo,et al.  Interpreting cancer genomes using systematic host perturbations by tumour virus proteins , 2012, Nature.

[20]  G. Wagner,et al.  A model of developmental evolution: selection, pleiotropy and compensation. , 2012, Trends in ecology & evolution.

[21]  Deok-Sun Lee,et al.  Viral Perturbations of Host Networks Reflect Disease Etiology , 2012, PLoS Comput. Biol..

[22]  P. Braun.  Interactome mapping for analysis of complex phenotypes: Insights from benchmarking binary interaction assays , 2012, Proteomics.

[23]  J. Aster,et al.  Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling , 2012, Proceedings of the National Academy of Sciences.

[24]  J. Majewski,et al.  Exome and whole‐genome sequencing for gene discovery: The future is now! , 2012, Human mutation.

[25]  Haiyuan Yu,et al.  Three-dimensional reconstruction of protein networks provides insight into human genetic disease , 2012, Nature Biotechnology.

[26]  J. Harper,et al.  Comprehensive Analysis of Host Cellular Interactions with Human Papillomavirus E6 Proteins Identifies New E6 Binding Partners and Reflects Viral Diversity , 2012, Journal of Virology.

[27]  John H. Morris,et al.  Global landscape of HIV–human protein complexes , 2011, Nature.

[28]  P. Visscher,et al.  Five years of GWAS discovery. , 2012, American journal of human genetics.

[29]  A. Wallberg,et al.  Cutaneous Papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling , 2011, Oncogene.

[30]  Y. Hérault,et al.  Missense Mutation in the Second RNA Binding Domain Reveals a Role for Prkra (PACT/RAX) during Skull Development , 2011, PloS one.

[31]  Marc Vidal,et al.  Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer , 2011, PLoS biology.

[32]  M. Muenke,et al.  Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH , 2012, Human Genetics.

[33]  Jonathan D. G. Jones,et al.  Evidence for Network Evolution in an Arabidopsis Interactome Map , 2011, Science.

[34]  Diana V. Dugas,et al.  Protein Interactome Reveals Converging Molecular Pathways Among Autism Disorders , 2011, Science Translational Medicine.

[35]  A. Barabasi,et al.  Interactome Networks and Human Disease , 2011, Cell.

[36]  A. Barabasi,et al.  Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia , 2010, Human molecular genetics.

[37]  M. Vidal,et al.  Protein-protein interactions and networks: forward and reverse edgetics. , 2011, Methods in molecular biology.

[38]  K. Bhat,et al.  An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. , 2010, Cancer cell.

[39]  M. Rietschel,et al.  Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder. , 2010, The American journal of psychiatry.

[40]  A. V. D. van den Ouweland,et al.  Genetic analysis of von Hippel‐Lindau disease , 2010, Human mutation.

[41]  Alexander van Oudenaarden,et al.  Variability in gene expression underlies incomplete penetrance , 2009, Nature.

[42]  David E Hill,et al.  High-quality binary interactome mapping. , 2010, Methods in enzymology.

[43]  M. Vidal,et al.  Edgetic perturbation models of human inherited disorders , 2009, Molecular systems biology.

[44]  M. Vidal,et al.  Edgetic perturbation of a C. elegans BCL2 ortholog , 2009, Nature Methods.

[45]  M. Vidal,et al.  Multimodal assessment of protein functional deficiency supports pathogenicity of BRCA1 p.V1688del. , 2009, Cancer research.

[46]  T. Doi,et al.  Predisposition to relapsing nephrotic syndrome by a nephrin mutation that interferes with assembly of functioning microdomains. , 2009, Human molecular genetics.

[47]  J. Decaprio.  How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40. , 2009, Virology.

[48]  David Warde-Farley,et al.  Dynamic modularity in protein interaction networks predicts breast cancer outcome , 2009, Nature Biotechnology.

[49]  Julie M. Sahalie,et al.  An experimentally derived confidence score for binary protein-protein interactions , 2008, Nature Methods.

[50]  A. Barabasi,et al.  An empirical framework for binary interactome mapping , 2008, Nature Methods.

[51]  M. Vidal,et al.  Literature-curated protein interaction , 2009 .

[52]  K. Gunsalus,et al.  Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network , 2009, Nature Methods.

[53]  M. Vidal,et al.  Literature-curated protein interaction datasets , 2009, Nature Methods.

[54]  A. Barabasi,et al.  High-Quality Binary Protein Interaction Map of the Yeast Interactome Network , 2008, Science.

[55]  Lilia M. Iakoucheva,et al.  A Protein Domain-Based Interactome Network for C. elegans Early Embryogenesis , 2008, Cell.

[56]  Janghoo Lim,et al.  Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1 , 2008, Nature.

[57]  R. Sharan,et al.  Protein networks in disease. , 2008, Genome research.

[58]  A. Bateman,et al.  Protein interactions in human genetic diseases , 2008, Genome Biology.

[59]  D. Driscoll,et al.  Altered RNA Binding Activity Underlies Abnormal Thyroid Hormone Metabolism Linked to a Mutation in Selenocysteine Insertion Sequence-binding Protein 2* , 2007, Journal of Biological Chemistry.

[60]  K. Gunsalus,et al.  Network modeling links breast cancer susceptibility and centrosome dysfunction. , 2007, Nature genetics.

[61]  Spyro Mousses,et al.  A transforming mutation in the pleckstrin homology domain of AKT1 in cancer , 2007, Nature.

[62]  J. Olson,et al.  Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration , 2007, PLoS genetics.

[63]  S. Teichmann,et al.  The folding and evolution of multidomain proteins , 2007, Nature Reviews Molecular Cell Biology.

[64]  E. Maher,et al.  Genotype–phenotype correlations in von Hippel‐Lindau disease , 2004, Human mutation.

[65]  W. Lim,et al.  Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. , 2006, Annual review of biochemistry.

[66]  J. Bonifacino,et al.  The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain , 2006, Nature Structural &Molecular Biology.

[67]  A. Barabasi,et al.  A Protein–Protein Interaction Network for Human Inherited Ataxias and Disorders of Purkinje Cell Degeneration , 2006, Cell.

[68]  V. Kim,et al.  The role of PACT in the RNA silencing pathway , 2006, The EMBO journal.

[69]  J. Moult,et al.  Loss of protein structure stability as a major causative factor in monogenic disease. , 2005, Journal of molecular biology.

[70]  S. L. Wong,et al.  Towards a proteome-scale map of the human protein–protein interaction network , 2005, Nature.

[71]  H. Lehrach,et al.  A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome , 2005, Cell.

[72]  Kumiko Ishikawa,et al.  A novel high-throughput (HTP) cloning strategy for site-directed designed chimeragenesis and mutation using the Gateway cloning system , 2005, Nucleic acids research.

[73]  Michael Albers,et al.  Automated Yeast Two-hybrid Screening for Nuclear Receptor-interacting Proteins*S , 2005, Molecular & Cellular Proteomics.

[74]  H. Lehrach,et al.  A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. , 2004, Molecular cell.

[75]  A. Barabasi,et al.  Network biology: understanding the cell's functional organization , 2004, Nature Reviews Genetics.

[76]  S. L. Wong,et al.  A Map of the Interactome Network of the Metazoan C. elegans , 2004, Science.

[77]  F. Holstege,et al.  A high resolution protein interaction map of the yeast Mediator complex. , 2004, Nucleic acids research.

[78]  James R. Knight,et al.  A Protein Interaction Map of Drosophila melanogaster , 2003, Science.

[79]  S. Kato,et al.  Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[80]  T. Pawson,et al.  Assembly of Cell Regulatory Systems Through Protein Interaction Domains , 2003, Science.

[81]  J. Drouin,et al.  Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency. , 2003, Genes & development.

[82]  D. Botstein,et al.  Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease , 2003, Nature Genetics.

[83]  M. Orozco,et al.  Characterization of disease-associated single amino acid polymorphisms in terms of sequence and structure properties. , 2002, Journal of molecular biology.

[84]  H. Brunner,et al.  Splitting p 63 , 2002 .

[85]  R. Sze,et al.  Another TWIST on Baller-Gerold syndrome. , 2001, American journal of medical genetics.

[86]  A. Miettinen,et al.  Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm. , 2001, The American journal of pathology.

[87]  D. J. Weatherall,et al.  Phenotype—genotype relationships in monogenic disease: lessons from the thalassaemias , 2001, Nature Reviews Genetics.

[88]  M. Daly,et al.  Guilt by association , 2000, Nature Genetics.

[89]  E R McCabe,et al.  Phenotypes of patients with "simple" Mendelian disorders are complex traits: thresholds, modifiers, and systems dynamics. , 2000, American journal of human genetics.

[90]  S Fields,et al.  Mutation detection by a two-hybrid assay. , 1998, Human molecular genetics.

[91]  Identification of a calcium channel modulator using a high-throughput yeast two-hybrid screen , 1998, Nature Biotechnology.

[92]  E. Fearon.  Human cancer syndromes: clues to the origin and nature of cancer. , 1997, Science.

[93]  M. Vidal,et al.  Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[94]  M. Vidal,et al.  Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[95]  O. Staub,et al.  WW domains of Nedd4 bind to the proline‐rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. , 1996, The EMBO journal.

[96]  S. Friend,et al.  A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene. , 1995, Oncogene.

[97]  David Botstein,et al.  Defining protein interactions with yeast actin in vivo , 1995, Nature Structural Biology.

[98]  Jonathan A. Cooper,et al.  Mammalian Ras interacts directly with the serine/threonine kinase raf , 1993, Cell.

[99]  S. Fields,et al.  The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[100]  S. Fields,et al.  A novel genetic system to detect protein–protein interactions , 1989, Nature.

[101]  G. Beadle,et al.  Genetic Control of Biochemical Reactions in Neurospora , 1941 .