Effect of canine cutaneous mast cell tumors to treatment with oral prednisone alone.

SUMMARY For 58 cases of canine mast cell tumors ， we measured the tumor volume reduction following one to four weeks of treatment with prednisolone administered once per day. The median dose of prednisolone was 2 1. 5 mg/m'. We observed tumor reduction in 35 cases ， with a response rate of 60 .4%. In addition ， the median times for obtaining a complete or partial response were 14 and 10.5 days ， respectively. Among the response group of 35 cases (complete response = 7 ， partial response = 28) and the non-response group of 23 cases (no change [stable diseasel = 18 ， additional swe 1li ng [progressive diseasel = 5) ， we observed a significant difference in the initial tumor volume (P < 0.001) ， with the median volume being 2.69 cm: l for the response group and 18.85 cm 3 for the non-response group. We have therefore reconfirmed the importance of using prednisolone as a treatment for canine mast cell tumors and we have c1 early shown that the smaller the tumor volume ， the more effec-tive the prednisolone treatment w i1l be.

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