Ultraviolet and visible spectroscopies for tissue diagnostics: fluorescence spectroscopy and elastic-scattering spectroscopy.

We review the application of fluorescence spectroscopy and elastic-scattering spectroscopy, over the ultraviolet-to-visible wavelength range, to minimally invasive medical diagnostics. The promises and hopes, as well as the difficulties, of these developing techniques are discussed.

[1]  D. Blankenhorn,et al.  Carotenoids in man; the distribution of epiphasic carotenoids in atherosclerotic lesions. , 1956, The Journal of clinical investigation.

[2]  D. Blankenhorn,et al.  Carotenoids in man. III. The microscopic pattern of fluorescence in atheromas, and its relation to their growth. , 1958, The Journal of clinical investigation.

[3]  Isiah M. Warner,et al.  Design considerations for a two-dimensional rapid scanning fluorimeter , 1979 .

[4]  D. J. Ellis,et al.  A theoretical and experimental study of light absorption and scattering by in vivo skin. , 1980, Physics in medicine and biology.

[5]  M. Morad,et al.  A new laser scanning system for measuring action potential propagation in the heart. , 1981, Science.

[6]  T. Kamada,et al.  Hemoperfusion, rate of oxygen consumption and redox levels of mitochondrial cytochrome c (+c1) in liver in situ of anesthetized rat measured by reflectance spectrophotometry. , 1981, Biochimica et biophysica acta.

[7]  R. Anderson,et al.  The optics of human skin. , 1981, The Journal of investigative dermatology.

[8]  O. Balchum,et al.  Fluorescence bronchoscopy for localization of carcinoma in situ. , 1983, Medical physics.

[9]  R. Alfano,et al.  Laser induced fluorescence spectroscopy from native cancerous and normal tissue , 1984 .

[10]  Robert R. Alfano,et al.  Human teeth with and without caries studied by laser scattering, fluorescence, and absorption spectroscopy , 1984 .

[11]  J. Berthier,et al.  In situ double-beam NADH laser fluorimetry: choice of a reference wavelength. , 1984, The American journal of physiology.

[12]  A E Profio,et al.  Fluorescence diagnosis of cancer. , 1985, Advances in experimental medicine and biology.

[13]  M. Feld,et al.  Diagnosis of fibrous arterial atherosclerosis using fluorescence. , 1985, Applied optics.

[14]  R R Alfano,et al.  Fluorescence polarization spectroscopy and time-resolved fluorescence kinetics of native cancerous and normal rat kidney tissues. , 1986, Biophysical journal.

[15]  D. Choy,et al.  Fluorescence spectra from cancerous and normal human breast and lung tissues , 1987, Annual Meeting Optical Society of America.

[16]  Frank K. Tittel,et al.  Autofluorescence maps of atherosclerotic human arteries--A new technique in medical imaging , 1987 .

[17]  D. Kessel.  Tumor localization and photosensitization by derivatives of hematoporphyrin: A review , 1987 .

[18]  L. Deckelbaum,et al.  In vivo fluorescence of human skin. A potential marker of photoaging. , 1988, Archives of Dermatology.

[19]  N Kollias,et al.  Quantitative assessment of UV-induced pigmentation and erythema. , 1988, Photo-dermatology.

[20]  R Richards-Kortum,et al.  Spectral diagnosis of atherosclerosis using an optical fiber laser catheter. , 1989, American heart journal.

[21]  F. Docchio.  Ocular fluorometry: Principles, fluorophores, instrumentation, and clinical applications , 1989, Lasers in surgery and medicine.

[22]  Michael S. Feld,et al.  A model for extraction of diagnostic information from laser induced fluorescence spectra of human artery wall , 1989 .

[23]  Combined in vivo NADH fluorescence and 31P NMR to evaluate myocardial oxidative phosphorylation , 1989 .

[24]  W Lohmann,et al.  Native fluorescence of the cervix uteri as a marker for dysplasia and invasive carcinoma. , 1989, European journal of obstetrics, gynecology, and reproductive biology.

[25]  J. Feather,et al.  A portable scanning reflectance spectrophotometer using visible wavelengths for the rapid measurement of skin pigments. , 1989, Physics in medicine and biology.

[26]  R. Rava,et al.  A one-layer model of laser-induced fluorescence for diagnosis of disease in human tissue: applications to atherosclerosis , 1989, IEEE Transactions on Biomedical Engineering.

[27]  L. Deckelbaum,et al.  Fluorescence spectroscopy guidance of laser ablation of atherosclerotic plaque , 1989 .

[28]  R M Cothren,et al.  Gastrointestinal tissue diagnosis by laser-induced fluorescence spectroscopy at endoscopy. , 1990, Gastrointestinal endoscopy.

[29]  Branko Palcic,et al.  Detection of lung cancer by ratio fluorometry with and without Photofrin II , 1990, Photonics West - Lasers and Applications in Science and Engineering.

[30]  J. Feather,et al.  An investigation of factors affecting the accuracy of in vivo measurements of skin pigments by reflectance spectrophotometry , 1990, Physics in medicine and biology.

[31]  Stefan Andersson-Engels,et al.  Laser-induced fluorescence in medical diagnostics , 1990, Photonics West - Lasers and Applications in Science and Engineering.

[32]  A. Welch,et al.  A review of the optical properties of biological tissues , 1990 .

[33]  R. Rava,et al.  SPECTROSCOPIC DIAGNOSIS OF COLONIC DYSPLASIA , 1991, Photochemistry and photobiology.

[34]  K. Ono,et al.  Fiber optic reflectance spectrophotometry system for in vivo tissue diagnosis. , 1991, Applied optics.

[35]  K Svanberg,et al.  FLUORESCENCE IMAGING AND POINT MEASUREMENTS OF TISSUE: APPLICATIONS TO THE DEMARCATION OF MALIGNANT TUMORS AND ATHEROSCLEROTIC LESIONS FROM NORMAL TISSUE , 1991, Photochemistry and photobiology.

[36]  B. Palcic,et al.  Autofluorescence of normal and malignant bronchial tissue , 1991, Lasers in surgery and medicine.

[37]  I. S. Saidi,et al.  Preliminary clinical results of a transcutaneous reflectance spectrophotometer for the detection of bilirubin in neonates , 1991 .

[38]  J. Tulip,et al.  Laser‐induced fluorescence emission: I. The spectroscopic identification of fibrotic endocardium and myocardium , 1991, Lasers in surgery and medicine.

[39]  J. Schmitt,et al.  Optical determination of dental pulp vitality , 1991, IEEE Transactions on Biomedical Engineering.

[40]  R Marchesini,et al.  In vivo SPECTROPHOTOMETRIC EVALUATION OF NEOPLASTIC AND NON‐NEOPLASTIC SKIN PIGMENTED LESIONS. II: DISCRIMINANT ANALYSIS BETWEEN NEVUS AND MELANOMA , 1992, Photochemistry and photobiology.

[41]  Jonathan A. Eppstein,et al.  Noninvasive detection of diabetes mellitus , 1992, Photonics West - Lasers and Applications in Science and Engineering.

[42]  T J Flotte,et al.  Ultraviolet laser‐induced fluorescence of colonic tissue: Basic biology and diagnostic potential , 1992, Lasers in surgery and medicine.

[43]  R. Rava,et al.  Analytical model for extracting intrinsic fluorescence in turbid media. , 1993, Applied optics.

[44]  Robert R. Alfano,et al.  Native fluorescence spectroscopy of thymus and fat tissues , 1993, Photonics West - Lasers and Applications in Science and Engineering.

[45]  J. Tulip,et al.  Laser Induced Fluorescence Identification of Sinoatrial and Atrioventricular Nodal Conduction Tissue , 1993, Pacing and clinical electrophysiology : PACE.

[46]  R. Richards-Kortum,et al.  Study of the fluorescence properties of normal and neoplastic human cervical tissue , 1993, Lasers in surgery and medicine.

[47]  K Svanberg,et al.  Clinical fluorescence diagnosis of human bladder carcinoma following low-dose Photofrin injection. , 1993, Urology.

[48]  O. Minet,et al.  Observations of the fluorescence response of the coenzyme NADH in biological samples. , 1993, Optics letters.

[49]  Irving J. Bigio,et al.  Noninvasive identification of bladder cancer with subsurface backscattered light , 1994, Photonics West - Lasers and Applications in Science and Engineering.

[50]  Shuming Nie,et al.  Rapid noninvasive optical characterization of the human lens , 1994 .

[51]  Anthony J. Durkin,et al.  Relation between fluorescence spectra of dilute and turbid samples. , 1994, Applied optics.

[52]  Stefan Andersson-Engels,et al.  Tissue characterization in some clinical specialities utilizing laser-induced fluorescence , 1994, Photonics West - Lasers and Applications in Science and Engineering.

[53]  Steven L. Jacques,et al.  Fluorescence of normal and cancerous brain tissues: the excitation/emission matrix , 1994, Photonics West - Lasers and Applications in Science and Engineering.

[54]  N Ramanujam,et al.  In vivo diagnosis of cervical intraepithelial neoplasia using 337-nm-excited laser-induced fluorescence. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[55]  N Ramanujam,et al.  Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia (CIN). , 1994, Gynecologic oncology.

[56]  L Reinisch,et al.  Noninvasive optical diagnosis of bacteria causing otitis media , 1994, The Laryngoscope.

[57]  N Ramanujam,et al.  In vivo fluorescence spectroscopy: potential for non-invasive, automated diagnosis of cervical intraepithelial neoplasia and use as a surrogate endpoint biomarker. , 1994, Journal of cellular biochemistry. Supplement.

[58]  E H Verdonschot,et al.  Light propagation through teeth containing simulated caries lesions. , 1995, Physics in medicine and biology.

[59]  Irving J. Bigio,et al.  Monte Carlo investigations of elastic scattering spectroscopy applied to latex spheres used as tissue phantoms , 1995, Photonics West.

[60]  Calum MacAulay,et al.  Laser-induced fluorescence spectroscopy at endoscopy: tissue optics, Monte Carlo modeling, and in vivo measurements , 1995 .

[61]  Judith R. Mourant,et al.  Detection of gastrointestinal cancer by elastic scattering and absorption spectroscopies with the Los Alamos Optical Biopsy System , 1995, Photonics West.

[62]  Steven L. Jacques,et al.  In vivo fluorescence spectroscopy for the diagnosis of skin diseases , 1995, Other Conferences.

[63]  W. Webb,et al.  Three‐dimensionally resolved NAD(P)H cellular metabolic redox imaging of the in situ cornea with two‐photon excitation laser scanning microscopy , 1995, Journal of microscopy.

[64]  T. Papazoglou,et al.  Malignancies and atherosclerotic plaque diagnosis--is laser induced fluorescence spectroscopy the ultimate solution? , 1995, Journal of photochemistry and photobiology. B, Biology.

[65]  C. Clemente,et al.  In vivo SPECTROPHOTOMETRIC EVALUATION OF NEOPLASTIC AND NONNEOPLASTIC SKIN PIGMENTED LESIONS. III. CCD CAMERA‐BASED REFLECTANCE IMAGING , 1995, Photochemistry and photobiology.

[66]  I J Bigio,et al.  Spectroscopic diagnosis of bladder cancer with elastic light scattering , 1995, Lasers in surgery and medicine.

[67]  R. Alfano,et al.  Ultraviolet excitation fluorescence spectroscopy: a noninvasive method for the measurement of redox changes in ischemic myocutaneous flaps. , 1995, Plastic and reconstructive surgery.

[68]  I. S. Saidi,et al.  Mie and Rayleigh modeling of visible-light scattering in neonatal skin. , 1995, Applied optics.

[69]  Rick E. Sneed,et al.  In vivo cancer diagnosis of the esophagus using differential normalized fluorescence (DNF) indices , 1995, Lasers in surgery and medicine.

[70]  R. Marchesini,et al.  Natural fluorescence of normal and neoplastic human colon: A comprehensive “ex vivo” study , 1995, Lasers in surgery and medicine.

[71]  The significance of fiber numerical aperture for optical measurements of turbid media , 1996 .

[72]  J. Mourant,et al.  Elastic scattering spectroscopy as a diagnostic tool for differentiating pathologies in the gastrointestinal tract: preliminary testing. , 1996, Journal of biomedical optics.