Numerical Simulation of the Blood Flow through a Brain Vascular Aneurysm with an Artificial Stent Using the SPH Method

We present numerical simulations of blood flow through a brain vascular aneurysm with an artificial stent using Smoothed Particle Hydrodynamics (SPH). The aim of this work is to analyze how the flow into an aneurysm changes using different stent configurations. The initial conditions for the simulations were constructed from angiographic images of a real patient with an aneurysm. The wall shear stresses, pressure and highest velocity within the artery, and other particular quantities are calculated which are of medical specific interest. The numerical simulations of the cerebral circulation help doctors to determine if the patient’s own vascular anatomy has the conditions to allow arterial stenting by endovascular method before the surgery or even evaluate the effect of different stent structure and materials. The results show that the flow downstream the aneurysm is highly modified by the stent configuration and that the best choice for reducing the flow in the aneurysm is to use a completely extended Endeavor stent.

[1]  Hitoshi Gotoh,et al.  Sub-particle-scale turbulence model for the MPS method , 2001 .

[2]  W. Freeman,et al.  New therapies for unruptured intracranial aneurysms. , 2013, Neurologic clinics.

[3]  D. Nichols,et al.  Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment , 2003, The Lancet.

[4]  Qingmao Hu,et al.  Computational evaluation of smoothed particle hydrodynamics for implementing blood flow modelling through CT reconstructed arteries. , 2017, Journal of X-ray science and technology.

[5]  Wei Sun,et al.  Modeling Left Ventricular Blood Flow Using Smoothed Particle Hydrodynamics , 2017, Cardiovascular engineering and technology.

[6]  R. Spetzler,et al.  Extracranial-intracranial bypass and vessel occlusion for the treatment of unclippable giant middle cerebral artery aneurysms. , 2013, Neurosurgery.

[7]  David H Frakes,et al.  Finite element modeling of embolic coil deployment: multifactor characterization of treatment effects on cerebral aneurysm hemodynamics. , 2013, Journal of biomechanics.

[8]  T. Tezduyar,et al.  Patient-specific computer modeling of blood flow in cerebral arteries with aneurysm and stent , 2012, Computational Mechanics.

[9]  C. Kleinstreuer,et al.  Fluid-structure interaction effects on sac-blood pressure and wall stress in a stented aneurysm. , 2005, Journal of biomechanical engineering.

[10]  M. Gómez-Gesteira,et al.  Boundary conditions generated by dynamic particles in SPH methods , 2007 .

[11]  A. Islam,et al.  Blood Flow Dynamics in Cerebral Aneurysm - A CFD Simulation , 2015 .

[12]  J. Klapp,et al.  Nonreflecting outlet boundary conditions for incompressible flows using SPH , 2017, 1709.09141.

[13]  J. Monaghan.  Smoothed particle hydrodynamics , 2005 .

[14]  S. Kyo,et al.  Hemodynamic infarction of the spinal cord: involvement of the gray matter plus the border-zone between the central and peripheral arteries , 2005, Spinal Cord.

[15]  B. Lubicz,et al.  Comparison of stents used for endovascular treatment of intracranial aneurysms , 2018, Expert review of medical devices.

[16]  Matthias Müller,et al.  Interactive blood simulation for virtual surgery based on smoothed particle hydrodynamics. , 2004, Technology and health care : official journal of the European Society for Engineering and Medicine.

[17]  A. Algra,et al.  Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trends , 2007, Journal of Neurology, Neurosurgery, and Psychiatry.

[18]  Guirong Liu,et al.  Smoothed Particle Hydrodynamics: A Meshfree Particle Method , 2003 .

[19]  Edmond Y.M. Lo,et al.  Simulation of near-shore solitary wave mechanics by an incompressible SPH method , 2002 .

[20]  J Mocco,et al.  Aneurysm Morphology and Prediction of Rupture: An International Study of Unruptured Intracranial Aneurysms Analysis , 2018, Neurosurgery.

[21]  J. Mocco,et al.  MORPHOLOGY PARAMETERS FOR INTRACRANIAL ANEURYSM RUPTURE RISK ASSESSMENT , 2008, Neurosurgery.

[22]  Ok Kyun Lim,et al.  Virtual stenting of intracranial aneurysms: application of hemodynamic modification analysis , 2016, Acta radiologica.

[23]  R. Spetzler,et al.  Management of giant internal carotid artery aneurysms. , 2014, World Neurosurgery.

[24]  S. Tjoumakaris,et al.  Treatment of large and giant intracranial aneurysms: cost comparison of flow diversion and traditional embolization strategies. , 2014, World neurosurgery.

[25]  R. Spetzler,et al.  SURGICAL TREATMENT OF COMPLEX INTRACRANIAL ANEURYSMS , 2008, Neurosurgery.

[26]  X Y Xu,et al.  The combination of magnetic resonance angiography and computational fluid dynamics: a critical review. , 1998, Critical reviews in biomedical engineering.

[27]  Kenji Takizawa,et al.  Patient-specific computer modeling of blood flow in cerebral arteries with aneurysm and stent , 2012, Computational Mechanics.

[28]  F Auricchio,et al.  Simulation of transcatheter aortic valve implantation: a patient-specific finite element approach , 2014, Computer methods in biomechanics and biomedical engineering.