Evaluation of the genetic toxicity of middle distillate fuels

Petroleum middle distillate (PMD) fuels are mixtures of hydrocarbons that distill between ∼ 170‐370°C. Commercial products that fall into this category include kerosine, diesel fuel, jet fuel, and home heating oil. These products contain both saturated (paraffins and cycloparaffins) and aromatic species, but because of the boiling range normally contain very small amounts of the 3‐6 ring polycyclic aromatic hydrocarbon (PAH) constituents, which are considered to be carcinogenic. Nevertheless, there is evidence of weak tumorigenic activity when these materials are repeatedly applied to mouse skin.

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