Evidence Based Herbal Medicine and Mental Health

Many cultures have developed folk herbal remedies for various symptoms of mental illness. An evidence base now is being developed for some of these “alternative” herbal remedies. There has been an increase in the number and proportion of clinical trials of complementary medicine, which suggests a trend toward an evidence-based approach. This review presents the scientific information regarding herbal medicine with evidence based approaches for saffron.

[1]  H. Hara,et al.  Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice. , 2012, European journal of pharmacology.

[2]  D. Trafalis,et al.  Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies. , 2012, Journal of agricultural and food chemistry.

[3]  S. Akhondzadeh,et al.  Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial , 2012, Psychopharmacology.

[4]  H. Sadeghnia,et al.  Effects of Saffron (Crocus sativus L.) and its Active Constituent, Crocin, on Recognition and Spatial Memory after Chronic Cerebral Hypoperfusion in Rats , 2012, Phytotherapy research : PTR.

[5]  Y. Urade,et al.  Crocin promotes non-rapid eye movement sleep in mice. , 2012, Molecular nutrition & food research.

[6]  A. Hensel,et al.  Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices , 2011, Neuroscience.

[7]  S. Akhondzadeh,et al.  A RANDOMIZED, DOUBLE-BLIND, PLACEBO - CONTROLLED STUDY OF SAFETY OF THE ADJUNCTIVE SAFFRON ON SEXUAL DYSFUNCTION INDUCED BY A SELECTIVE SEROTONIN REUPTAKE INHIBITOR , 2011 .

[8]  Ji-Ho Park,et al.  Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. , 2010, European journal of pharmacology.

[9]  S. Akhondzadeh,et al.  Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16‐week, randomized and placebo‐controlled trial , 2010, Journal of clinical pharmacy and therapeutics.

[10]  M. Khalili,et al.  Effects of active constituents of Crocus sativus L., crocin on streptozocin-induced model of sporadic Alzheimer's disease in male rats. , 2010, Iranian biomedical journal.

[11]  K. Nahid,et al.  The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial. , 2009, Journal of midwifery & women's health.

[12]  O. Rajabi,et al.  Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study. , 2009, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[13]  H. Hosseinzadeh,et al.  Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice , 2009, Phytotherapy research : PTR.

[14]  S. Akhondzadeh,et al.  A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease , 2009, Psychopharmacology.

[15]  P. Tarantilis,et al.  Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety. , 2008, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[16]  H. Hosseinzadeh,et al.  Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. , 2008, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[17]  H. Hosseinzadeh,et al.  The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. , 2008, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[18]  A. Hensel,et al.  Quality and functionality of saffron: quality control, species assortment and affinity of extract and isolated saffron compounds to NMDA and sigma1 (sigma-1) receptors. , 2008, Planta medica.

[19]  S. Akhondzadeh,et al.  Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double‐blind, randomised and placebo‐controlled trial , 2008, BJOG : an international journal of obstetrics and gynaecology.

[20]  P. Tarantilis,et al.  Effects of the active constituents of Crocus sativus L., crocins on recognition and spatial rats’ memory , 2007, Behavioural Brain Research.

[21]  H. Sadeghnia,et al.  Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. , 2007, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[22]  S. Akhondzadeh,et al.  Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: A pilot double-blind randomized trial , 2007, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[23]  Yong-qiu Zheng,et al.  Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia , 2007, Brain Research.

[24]  L. L'Abate.  Low-cost approaches to promote physical and mental health : theory, research and practice , 2007 .

[25]  S. Akhondzadeh,et al.  Herbal Medicines In The Treatment of Psychiatric and Neurological Disorders , 2007 .

[26]  N. Pitsikas,et al.  Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat , 2006, Behavioural Brain Research.

[27]  Shahin Akhondzadeh,et al.  Herbal medicine in the treatment of Alzheimer's disease , 2006, American journal of Alzheimer's disease and other dementias.

[28]  H. Sadeghnia,et al.  Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. , 2005, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[29]  M. Ansari,et al.  Neuroprotection by crocetin in a hemi-parkinsonian rat model , 2005, Pharmacology Biochemistry and Behavior.

[30]  S. Akhondzadeh,et al.  Crocus sativus L. in the treatment of mild to moderate depression: a double‐blind, randomized and placebo‐controlled trial , 2004, Phytotherapy research : PTR.

[31]  S. Akhondzadeh,et al.  Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial [ISRCTN45683816] , 2004, BMC complementary and alternative medicine.

[32]  S. K. Abraham,et al.  Protective effects of saffron (Crocus sativus Linn.) on genotoxins‐induced oxidative stress in Swiss albino mice , 2003, Phytotherapy research : PTR.

[33]  S. Akhondzadeh.  The 5-HT hypothesis of schizophrenia. , 2001, IDrugs : the investigational drugs journal.

[34]  H. Saito,et al.  Effects of saffron extract and its constituent crocin on learning behaviour and long‐term potentiation , 2000, Phytotherapy research : PTR.

[35]  S. Akhondzadeh.  Hippocampal synaptic plasticity and cognition , 1999, Journal of clinical pharmacy and therapeutics.

[36]  B. Wüthrich,et al.  Anaphylaxis to saffron , 1997, Allergy.

[37]  S. Akhondzadeh,et al.  Interaction between adenosine and GABAA receptors on hippocampal neurones , 1994, Brain Research.

[38]  H. Saito,et al.  Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. , 1994, Biological & pharmaceutical bulletin.

[39]  G. Eisenbrand,et al.  Crocus sativus L. , 1992 .