Elevated Interleukin‐8 in Cervical Mucus as an Indicator for Treatment to Prevent Premature Birth and Preterm, Pre‐labor Rupture of Membranes: a Prospective Study

Problem:  We investigated whether cervical shortening and high interleukin (IL)‐8 in cervical mucus were valuable indications for treatment to prevent premature birth and preterm, pre‐labor rupture of membranes (pPROM).

[1]  R. Kelly,et al.  Choriodecidual production of interleukin-8 and mechanism of parturition , 1992, The Lancet.

[2]  G. Rizzo,et al.  The diagnostic value of interleukin-8 and fetal fibronectin concentrations in cervical secretions in patients with preterm labor and intact membranes , 1997, Journal of perinatal medicine.

[3]  J. Carey,et al.  Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis , 2001 .

[4]  C. Shellhaas,et al.  The Diagnosis and Management of Preterm Labor , 2001, The journal of obstetrics and gynaecology research.

[5]  William McGuire,et al.  Epidemiology of preterm birth , 2004, BMJ : British Medical Journal.

[6]  J. Hauth,et al.  Intrauterine infection and preterm delivery. , 2000, The New England journal of medicine.

[7]  S. Brennecke,et al.  Elevated Interleukin-8 Concentrations in Cervical Secretions Are Associated with Preterm Labour , 2001, Gynecologic and Obstetric Investigation.

[8]  J. Balducci,et al.  Revisiting the short cervix detected by transvaginal ultrasound in the second trimester: why cerclage therapy may not help. , 2001, American journal of obstetrics and gynecology.

[9]  B. Blondel,et al.  [The length of the cervix and the risk of spontaneous premature delivery]. , 1996, Revue d'epidemiologie et de sante publique.

[10]  R. Romero,et al.  Neutrophil attractant/activating peptide-1/interleukin-8 in term and preterm parturition. , 1991, American journal of obstetrics and gynecology.

[11]  M. Plebani,et al.  Biochemical markers for the prediction of spontaneous pre‐term birth , 2002, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[12]  H. Andersen.  Use of fetal fibronectin in women at risk for preterm delivery. , 2000, Clinical obstetrics and gynecology.

[13]  G. Rizzo,et al.  Ultrasonographic assessment of the uterine cervix and interleukin‐8 concentrations in cervical secretions predict intrauterine infection in patients with preterm labor and intact membranes , 1998, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[14]  L Deligdisch,et al.  Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery. , 1991, The New England journal of medicine.

[15]  M. Mitchell,et al.  Predicting preterm delivery: comparison of cervicovaginal interleukin (IL)-1beta, IL-6 and IL-8 with fetal fibronectin and cervical dilatation. , 2001, European journal of obstetrics, gynecology, and reproductive biology.

[16]  Y. Sasaki,et al.  Interleukin‐8 Levels and Granulocyte Counts in Cervical Mucus During Pregnancy , 2000, American journal of reproductive immunology.

[17]  C. Lockwood.  Predicting premature delivery--no easy task. , 2002, The New England journal of medicine.

[18]  Andersen Hf.  Use of fetal fibronectin in women at risk for preterm delivery. , 2000 .

[19]  T. Terao,et al.  Interleukin-8 induces cervical ripening in rabbits. , 1994, American journal of obstetrics and gynecology.

[20]  J. Hauth,et al.  Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis , 1995, The New England journal of medicine.

[21]  T. Kameda,et al.  Human placenta constitutively produces interleukin-8 during pregnancy and enhances its production in intrauterine infection. , 1992, Biology of reproduction.