CYP2D6 and CYP2C19 genotype‐based dose recommendations for antidepressants: a first step towards subpopulation‐specific dosages
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S. Kasper | J. Brockmöller | I. Roots | K. Brøsen | L. Gram | E. Spina | M. Dahl | F. Sjöqvist | J. Kirchheiner | J. Kirchheiner | K. Brøsen | M. L. Dahl | L. F. Gram | S. Kasper | I. Roots | F. Sjöqvist | E. Spina | J. Brockmöller | S. Kasper
[1] Clomipramine dose‐effect study in patients with depression: Clinical end points and pharmacokinetics , 1999, Clinical pharmacology and therapeutics.
[2] C. Alm,et al. Disposition of fluvoxamine in humans is determined by the polymorphic CYP2D6 and also by the CYP1A2 activity , 1996, Clinical pharmacology and therapeutics.
[3] C. Hiemke,et al. The role of cytochrome P450 2D6 in the metabolism of moclobemide , 1996, European Neuropsychopharmacology.
[4] T Ishizaki,et al. Genotyping of S‐mephenytoin 4′‐hydroxylation in an extended Japanese population , 1996, Clinical pharmacology and therapeutics.
[5] L. Bertilsson,et al. Genetically variable metabolism of antidepressants and neuroleptic drugs in man. , 1993, Pharmacogenetics.
[6] E. Griesser,et al. Biotransformation of moclobemide in humans , 1990, Acta psychiatrica Scandinavica. Supplementum.
[7] P. Beaune,et al. Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver. , 1993, Molecular pharmacology.
[8] M Schwab,et al. Elucidation of the genetic basis of the common 'intermediate metabolizer' phenotype for drug oxidation by CYP2D6. , 2000, Pharmacogenetics.
[9] M. Scheinin,et al. Disposition of single oral doses of E‐10‐hydroxynortriptyline in healthy subjects, with some observations on pharmacodynamic effects , 1986, Clinical pharmacology and therapeutics.
[10] T. Cooper,et al. Determination of trimipramine and metabolites in plasma by liquid chromatography with electrochemical detection. , 1984, Journal of Pharmacy and Science.
[11] M. Dahl,et al. Pharmacogenetics of antidepressants: clinical aspects , 1997, Acta psychiatrica Scandinavica. Supplementum.
[12] L. Bertilsson,et al. Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptyline. , 1979, Life sciences.
[13] D. Greenblatt,et al. O- and N-demethylation of Venlafaxine In Vitro by Human Liver Microsomes and by Microsomes from cDNA-Transfected Cells: Effect of Metabolic Inhibitors and SSRI Antidepressants , 1999, Neuropsychopharmacology.
[14] B. Mellström,et al. Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes , 1984, Clinical pharmacology and therapeutics.
[15] J. Brockmöller,et al. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. , 1997, American journal of human genetics.
[16] R. Barbhaiya,et al. Clinical Pharmacokinetics of Nefazodone , 1997, Clinical pharmacokinetics.
[17] G R Wilkinson,et al. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. , 1994, The Journal of biological chemistry.
[18] L. Bertilsson,et al. Interethnic factors affecting drug response , 1994 .
[19] C. Eap,et al. Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-phenotyped patients. , 2000, Therapeutic drug monitoring.
[20] C. Bye,et al. Paroxetine plasma levels: lack of correlation with efficacy or adverse events , 1989, Acta psychiatrica Scandinavica. Supplementum.
[21] O. Spigset,et al. Lack of correlation between fluvoxamine clearance and CYP1A2 activity as measured by systemic caffeine clearance , 1999, European Journal of Clinical Pharmacology.
[22] L. Gram,et al. Plasma Level Monitoring of Tricyclic Antidepressant Therapy , 1977, Clinical pharmacokinetics.
[23] R. Blouin,et al. Comparison of the pharmacokinetics of moclobemide in poor and efficient metabolizers of debrisoquine , 1990, Acta psychiatrica Scandinavica. Supplementum.
[24] D. Greenblatt,et al. Five Distinct Human Cytochromes Mediate Amitriptyline N‐Demethylation In Vitro: Dominance of CYP 2C19 and 3A4 , 1998, Journal of clinical pharmacology.
[25] S. Preskorn. Pharmacokinetics of antidepressants: why and how they are relevant to treatment. , 1993, The Journal of clinical psychiatry.
[26] K. Brøsen,et al. Imipramine metabolism in relation to the sparteine oxidation polymorphism--a family study. , 1996, Pharmacogenetics.
[27] L. Bertilsson,et al. Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio. , 1985, British journal of clinical pharmacology.
[28] J. Haskins,et al. Biochemical, neurophysiological, and behavioral effects of Wy‐45,233 and other identified metabolites of the antidepressant venlafaxine , 1991 .
[29] Harold I. Kaplan,et al. Synopsis of psychiatry: Behavioral sciences : clinical psychiatry , 1988 .
[30] M. Ingelman-Sundberg,et al. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[31] B. Pollock,et al. Newer antidepressants and the cytochrome P450 system. , 1996, The American journal of psychiatry.
[32] K. Otani,et al. Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine. , 1996, Therapeutic drug monitoring.
[33] O. Spigset,et al. Effect of cigarette smoking on fluvoxamine pharmacokinetics in humans , 1995, Clinical pharmacology and therapeutics.
[34] D. Pessayre,et al. Metabolic activation of the new tricyclic antidepressant tianeptine by human liver cytochrome P450. , 1990, Biochemical pharmacology.
[35] E. Steiner,et al. Differences in the inhibitory effect of cimetidine on desipramine metabolism between rapid and slow debrisoquin hydroxylators , 1987, Clinical pharmacology and therapeutics.
[36] Kaoru Kobayashi,et al. Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro. , 1999, Drug metabolism and disposition: the biological fate of chemicals.
[37] F. Sjöqvist,et al. Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds. , 1967, Life sciences.
[38] J. Idle,et al. POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN , 1977, The Lancet.
[39] P. Baumann,et al. Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin. , 1986, International clinical psychopharmacology.
[40] C. Nemeroff,et al. New antidepressants and the cytochrome P450 system: Focus on venlafaxine, nefazodone, and mirtazapine , 1998, Depression and anxiety.
[41] L. Bertilsson,et al. Active Hydroxymetabolites of Antidepressants , 1995, Clinical pharmacokinetics.
[42] R. Dahlqvist,et al. Inhibition of desipramine 2-hydroxylation by quinidine and quinine in rapid and slow debrisoquine hydroxylators. , 1989, Psychopharmacology series.
[43] I. Poggesi,et al. Review of the pharmacokinetics and metabolism of reboxetine, a selective noradrenaline reuptake inhibitor , 1997, European Neuropsychopharmacology.
[44] D. Wong,et al. Fluoxetine and its two enantiomers as selective serotonin uptake inhibitors. , 1990, Acta pharmaceutica Nordica.
[45] L. Bertilsson,et al. Pharmacokinetics of nortriptyline and its 10‐hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes , 1998, Clinical pharmacology and therapeutics.
[46] O. Spigset,et al. Relationship between fluvoxamine pharmacokinetics and CYP2D6/CYP2C19 phenotype polymorphisms , 1997, European Journal of Clinical Pharmacology.
[47] A. Bozkurt,et al. Low frequency of defective alleles of cytochrome P450 enzymes 2C19 and 2D6 in the Turkish population , 1999, Clinical pharmacology and therapeutics.
[48] Tricyclic antidepressants--blood level measurements and clinical outcome: an APA Task Force report. Task Force on the Use of Laboratory Tests in Psychiatry. , 1985, The American journal of psychiatry.
[49] M. S. Ching,et al. Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin. , 2000, Pharmacogenetics.
[50] S. Ekins,et al. Three-dimensional quantitative structure activity relationship analyses of substrates for CYP2B6. , 1999, The Journal of pharmacology and experimental therapeutics.
[51] S. Otton,et al. Imipramine demethylation and hydroxylation: Impact of the sparteine oxidation phenotype , 1986, Clinical pharmacology and therapeutics.
[52] M. Ingelman-Sundberg,et al. Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine , 1993, The Lancet.
[53] L. Bertilsson,et al. 10‐hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes , 1998, Clinical pharmacology and therapeutics.
[54] R. Blouin,et al. The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: Screening costs and influence on clinical outcomes in psychiatry , 1996, Clinical pharmacology and therapeutics.
[55] B. Mellström,et al. Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes. , 1981, Drug metabolism and disposition: the biological fate of chemicals.
[56] L. Bertilsson,et al. Geographical/Interracial Differences in Polymorphic Drug Oxidation , 1995, Clinical pharmacokinetics.
[57] E. Skjelbo,et al. The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R-ratio). A population study. , 1993, British journal of clinical pharmacology.
[58] L. Bertilsson,et al. Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians: comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype. , 1995, Pharmacogenetics.
[59] S. Stahl,et al. Mirtazapine: An Antidepressant with Noradrenergic and Specific Serotonergic Effects , 1997, Pharmacotherapy.
[60] O. Spigset,et al. Non-linear fluvoxamine disposition. , 1998, British journal of clinical pharmacology.
[61] U. Meyer,et al. Role of P450IID6, the target of the sparteine‐debrisoquin oxidation polymorphism, in the metabolism of imipramine , 1991, Clinical pharmacology and therapeutics.
[62] S. Sindrup,et al. Role of genetic polymorphism in psychopharmacology--an update. , 1993, Psychopharmacology series.
[63] M. Eastwood,et al. NEUTROPHIL FUNCTION AND MYELOPEROXIDASE ACTIVITY IN INFLAMMATORY BOWEL DISEASE , 1976, The Lancet.
[64] K. Brøsen,et al. First‐pass metabolism of imipramine and desipramine: Impact of the sparteine oxidation phenotype , 1988, Clinical pharmacology and therapeutics.
[65] P. Baumann,et al. Dextromethorphan and Mephenytoin Phenotyping of Patients Treated with Thioridazine or Amitriptyline , 1992, Therapeutic drug monitoring.
[66] E. Skjelbo,et al. Fluoxetine and norfluoxetine are potent inhibitors of P450IID6--the source of the sparteine/debrisoquine oxidation polymorphism. , 1991, British journal of clinical pharmacology.
[67] M. Eichelbaum,et al. Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population. , 1998, Pharmacogenetics.
[68] K. Otani,et al. Is there a therapeutic window for plasma concentration of mianserin plus desmethylmianserin? , 1991 .
[69] R. Haddock,et al. Metabolic pathway of paroxetine in animals and man and the comparative pharmacological properties of its metabolites , 1989, Acta psychiatrica Scandinavica. Supplementum.
[70] J. Azuma,et al. The impact of the CYP2D6 and CYP2C19 genotypes on venlafaxine pharmacokinetics in a Japanese population , 2000, European Journal of Clinical Pharmacology.
[71] E. Skjelbo,et al. Inhibitors of imipramine metabolism by human liver microsomes. , 1992, British journal of clinical pharmacology.
[72] S. Preskorn,et al. Clinically Relevant Pharmacology of Selective Serotonin Reuptake Inhibitors , 1997, Clinical pharmacokinetics.
[73] M. Dahl,et al. Pharmacogenetic methods as a complement to therapeutic monitoring of antidepressants and neuroleptics. , 2000, Therapeutic drug monitoring.
[74] P. Baumann,et al. N-methylation of maprotiline in debrisoquine/mephenitoin-phenotyped depressive patients , 1985 .
[75] J. Rapoport,et al. Active metabolites of imipramine and desipramine in man , 1982, Clinical pharmacology and therapeutics.
[76] R. Post,et al. The emerging role of cytochrome P450 3A in psychopharmacology. , 1995, Journal of clinical psychopharmacology.
[77] E. Hoencamp,et al. Venlafaxine serum levels and CYP2D6 genotype. , 2000, Therapeutic drug monitoring.
[78] Joe C. Watson,et al. Report from the Second European Stroke Summer School, Heidelberg, Germany , 1999, Cerebrovascular Diseases.
[79] E. Sellers,et al. Venlafaxine oxidation in vitro is catalysed by CYP2D6. , 1996, British journal of clinical pharmacology.
[80] K. Brøsen,et al. Imipramine demethylation in vivo: Impact of CYP1A2, CYP2C19, and CYP3A4 , 1997, Clinical pharmacology and therapeutics.
[81] R. Dahlqvist,et al. Inhibition of desipramine 2‐hydroxylation by quinidine and quinine , 1988, Clinical pharmacology and therapeutics.
[82] T. Someya,et al. Metabolism of desipramine in Japanese psychiatric patients: the impact of CYP2D6 genotype on the hydroxylation of desipramine. , 2000, Pharmacology & toxicology.
[83] L. Bertilsson,et al. E‐ and Z‐10‐hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxylation , 1981, Clinical pharmacology and therapeutics.
[84] K. Brøsen,et al. Pharmacokinetics of Citalopram in Relation to the Sparteine and the Mephenytoin Oxidation Polymorphisms , 1993, Therapeutic drug monitoring.
[85] J. Hallas,et al. The mephenytoin oxidation polymorphism is partially responsible for the N‐demethylation of imipramine , 1991, Clinical pharmacology and therapeutics.
[86] F. Macciardi,et al. Steady state concentrations of the enantiomers of mianserin and desmethylmianserin in poor and in homozygous and heterozygous extensive metabolizers of debrisoquine. , 1998, Therapeutic drug monitoring.
[87] L. Bertilsson,et al. CYP2C19 genotype and phenotype determined by omeprazole in a Korean population. , 1996, Pharmacogenetics.
[88] Nonlinear pharmacokinetics of chlorimipramine after infusion and oral administration in patients , 1986, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[89] M. Åsberg,et al. Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depression , 1979, Clinical pharmacology and therapeutics.
[90] U. Gundert-Remy,et al. Non-response to maprotiline caused by ultra-rapid metabolism that is different from CYP2D6? , 1997, European Journal of Clinical Pharmacology.
[91] S. Tsuchida,et al. Relationship between the CYP2D6 genotype and the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine , 1997, Psychopharmacology.
[92] K. Otani,et al. Inhibition of Trazodone Metabolism by Thioridazine in Humans , 1995, Therapeutic drug monitoring.
[93] J. Hallas,et al. The relationship between paroxetine and the sparteine oxidation polymorphism , 1992, Clinical pharmacology and therapeutics.
[94] A. Fro̸land,et al. Imipramine treatment of painful diabetic neuropathy. , 1984, JAMA.
[95] K. Chiba,et al. Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers. , 1996, The Journal of pharmacology and experimental therapeutics.
[96] B. Pollock,et al. Antidepressants and drug‐metabolizing enzymes — expert group report , 1996, Acta psychiatrica Scandinavica.
[97] L. Bertilsson,et al. The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine. , 1983, British journal of clinical pharmacology.
[98] T Ishizaki,et al. Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. , 1997, The Journal of pharmacology and experimental therapeutics.
[99] B. Woggon,et al. Importance of Oxidative Polymorphism on Clinical Efficacy and Side-Effects of Imipramine - A Retrospective Study , 1988, Pharmacopsychiatry.
[100] C J Timmer,et al. Clinical Pharmacokinetics of Mirtazapine , 2000, Clinical pharmacokinetics.
[101] J. Turgeon,et al. The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin , 1996, Clinical pharmacology and therapeutics.
[102] T. Winkler,et al. Isolation and identification of hydroxylated maprotiline metabolites. , 1985, Xenobiotica; the fate of foreign compounds in biological systems.
[103] D. Wong,et al. Norfluoxetine Enantiomers as Inhibitors of Serotonin Uptake in Rat Brain , 1993, Neuropsychopharmacology.
[104] L. Ereshefsky. Drug-Drug Interactions Involving Antidepressants: Focus on Venlafaxine , 1996, Journal of clinical psychopharmacology.
[105] J. Goldstein,et al. A multifamily study on the relationship between CYP2C19 genotype and s-mephenytoin oxidation phenotype. , 1995, Pharmacogenetics.
[106] M. Ingelman-Sundberg,et al. Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population , 1992, Clinical pharmacology and therapeutics.
[107] L. Bertilsson,et al. Amitriptyline metabolism: Relationship to polymorphic debrisoquine hydroxylation , 1983, Clinical pharmacology and therapeutics.
[108] M. Åsberg,et al. Monitoring Tricyclic Antidepressants , 1980, Therapeutic drug monitoring.
[109] L. Bertilsson,et al. Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants. , 1985, Therapeutic drug monitoring.
[110] K. Brøsen,et al. The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine. , 1999, Pharmacogenetics.
[111] J. Miners,et al. Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. , 1998, British journal of clinical pharmacology.
[112] J. Azuma,et al. Effect of the CYP2D6*10 genotype on venlafaxine pharmacokinetics in healthy adult volunteers. , 1999, British journal of clinical pharmacology.
[113] L. Wienkers,et al. Cytochrome P-450-mediated metabolism of the individual enantiomers of the antidepressant agent reboxetine in human liver microsomes. , 1999, Drug metabolism and disposition: the biological fate of chemicals.
[114] J. Amsterdam,et al. Fluoxetine and norfluoxetine plasma concentrations in major depression: a multicenter study. , 1997, The American journal of psychiatry.
[115] J. de Leon,et al. Pilot study of the cytochrome P450-2D6 genotype in a psychiatric state hospital. , 1998, The American journal of psychiatry.
[116] B. Alexanderson,et al. Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy , 1969, British medical journal.
[117] J. Hyttel. Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs) , 1994, International clinical psychopharmacology.
[118] E. Richelson. Pharmacokinetic interactions of antidepressants. , 1998, The Journal of clinical psychiatry.
[119] Interethnic dissociation between debrisoquine and desipramine hydroxylation. , 1985, Journal of clinical psychopharmacology.
[120] U. Meyer,et al. Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes. , 1997, Pharmacogenetics.
[121] C. Alm,et al. Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism , 1994, Clinical pharmacology and therapeutics.
[122] J. T. Stewart,et al. Quantitation of trimipramine enantiomers in human serum by enantioselective high-performance liquid chromatography and mixed-mode disc solid-phase extraction. , 1997, Journal of chromatography. B, Biomedical sciences and applications.
[123] G. Granneman,et al. Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions , 1997, Clinical pharmacokinetics.
[124] R. McAuley,et al. Relationship between mianserin plasma levels and antidepressant effect in a double-blind trial comparing a single night-time and divided daily dose regimens. , 1978, British journal of clinical pharmacology.
[125] C. Alm,et al. In Vitro and In Vivo Studies on the Disposition of Mirtazapine in Humans , 1997 .
[126] K. Brøsen,et al. Single‐dose kinetics of clomipramine: Relationship to the sparteine and S‐mephenytoin oxidation polymorphisms , 1994, Clinical pharmacology and therapeutics.
[127] T. Buclin,et al. Influence of quinidine on the pharmacokinetics of trimipramine and on its effect on the waking EEG of healthy volunteers. A pilot study on two subjects. , 1992, Neuropsychobiology.
[128] M. Eichelbaum,et al. Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population. , 1991, DNA and cell biology.
[129] B. Pollock,et al. Bupropion plasma levels and CYP2D6 phenotype. , 1996, Therapeutic drug monitoring.
[130] L. Gram. Drug therapy : fluoxetine , 1994 .
[131] Metabolism of trimipramine in vitro by human CYP2D6 isozyme. , 1993, Research communications in chemical pathology and pharmacology.
[132] J. Heym,et al. Comparison of the Effects of Sertraline and Its Metabolite Desmethylsertraline on Blockade of Central 5-HT Reuptake In Vivo , 1996, Neuropsychopharmacology.
[133] M. Kosel,et al. Ultrarapid metabolism of clomipramine in a therapy-resistant depressive patient, as confirmed by CYP2 D6 genotyping. , 1998, Pharmacopsychiatry.
[134] K. Brøsen,et al. Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study * , 1995, Clinical pharmacology and therapeutics.
[135] S. Caccia. Metabolism of the Newer Antidepressants , 1998, Clinical pharmacokinetics.
[136] J S Harmatz,et al. Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation. , 2003, British journal of clinical pharmacology.
[137] B. Woods,et al. Maprotiline treatment in depression. A perspective on seizures. , 1986, Archives of general psychiatry.
[138] S. Wrighton,et al. Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes P450. , 1993, The Journal of pharmacology and experimental therapeutics.
[139] L. Hollister. Second-generation antidepressants. , 1982, Rational drug therapy.
[140] K. Chiba,et al. Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients. , 1996, Journal of clinical psychopharmacology.
[141] D. H. Schroeder,et al. Carbamazepine but not valproate induces bupropion metabolism. , 1995, Journal of clinical psychopharmacology.
[142] Ö. Ericsson,et al. Hydroxylation of desmethylimipramine: Dependence on the debrisoquin hydroxylation phenotype , 1987, Clinical pharmacology and therapeutics.
[143] R. Barbhaiya,et al. Single and multiple dose pharmacokinetics of nefazodone in subjects classified as extensive and poor metabolizers of dextromethorphan. , 1996, British journal of clinical pharmacology.
[144] L. Bertilsson,et al. CYP2C19 genotype and phenotype determined with omeprazole in patients with acid-related disorders with and without Helicobacter pylori infection. , 1998, Scandinavian journal of gastroenterology.
[145] O. Olesen,et al. Studies on the Stereoselective Metabolism of Citalopram by Human Liver Microsomes and cDNA-Expressed Cytochrome P450 Enzymes , 1999, Pharmacology.
[146] T. Barnes,et al. How to distinguish between the neuroleptic-induced deficit syndrome, depression and disease-related negative symptoms in schizophrenia , 1995, International clinical psychopharmacology.
[147] K. Brøsen,et al. Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms--a population study. , 1995, British journal of clinical pharmacology.
[148] K. Brøsen. Differences in interactions of SSRIs , 1998, International clinical psychopharmacology.
[149] B. Testa,et al. Determination of the enantiomers of citalopram, its demethylated and propionic acid metabolites in human plasma by chiral HPLC. , 1995, Chirality.
[150] E. Spina,et al. Urinary Desipramine Hydroxylation Index and Steady‐State Plasma Concentrations of Imipramine and Desipramine , 1987, Therapeutic drug monitoring.
[151] L. Bertilsson,et al. The CYP2D6 genotype and plasma concentrations of mianserin enantiomers in relation to therapeutic response to mianserin in depressed Japanese patients. , 1997, Journal of clinical psychopharmacology.
[152] J. Turgeon,et al. Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans. , 1999, Pharmacogenetics.
[153] R. Fuller,et al. Comparison of norfluoxetine enantiomers as serotonin uptake inhibitors in vivo , 1992, Neuropharmacology.
[154] J. Turgeon,et al. Involvement of CYP2D6 activity in the N-oxidation of procainamide in man. , 1999, Pharmacogenetics (London).
[155] P. Baumann,et al. Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes , 1992, Clinical pharmacology and therapeutics.
[156] L. Bertilsson,et al. Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man. , 1980, Life sciences.
[157] O. Spigset,et al. Seizures and myoclonus associated with antidepressant treatment: assessment of potential risk factors, including CYP2D6 and CYP2C19 polymorphisms, and treatment with CYP2D6 inhibitors , 1997, Acta psychiatrica Scandinavica.
[158] P. Corey,et al. Incidence of Adverse Drug Reactions in Hospitalized Patients , 2012 .
[159] C. Gleiter,et al. Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine. , 1994, British journal of clinical pharmacology.
[160] U. Meyer,et al. Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification , 1990, The Lancet.
[161] Z. Kopitar,et al. [Pharmacokinetics and metabolism of trazodone in man (author's transl)]. , 1976, Arzneimittel-Forschung.
[162] K. Otani,et al. Effects of various factors on steady state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine. , 1995, International clinical psychopharmacology.
[163] K. Brøsen,et al. Duplication of CYP2D6 predicts high clearance of desipramine but high clearance does not predict duplication of CYP2D6 , 2001, European Journal of Clinical Pharmacology.
[164] K. Chiba,et al. Effects of genetic defects in the CYP2C19 gene on the N‐demethylation of imipramine, and clinical outcome of imipramine therapy , 1997, Psychiatry and clinical neurosciences.
[165] L. Bertilsson,et al. Amitriptyline metabolism: Association with debrisoquin hydroxylation in nonsmokers , 1986, Clinical pharmacology and therapeutics.
[166] C. Mazure,et al. Antidepressant activity of 2‐hydroxydesipramine , 1988, Clinical pharmacology and therapeutics.