Sustained pain hypersensitivity in the stressed colon: Role of mast cell‐derived nerve growth factor‐mediated enteric synaptic plasticity

Sustained pain hypersensitivity is the hallmark of stressed colon which could be partially explained by central sensitization with synaptic plasticity, the key mechanism of memory. We previously identified that synaptic plasticity of enteric nerve system (ENS) contributed to peripheral pain maintaining in the gut. However, the mechanisms of enteric “memory” formation remain elusive.

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