Mathematical Models to Explore Potential Effects of Supersaturation and Precipitation on Oral Bioavailability of Poorly Soluble Drugs
暂无分享,去创建一个
[1] M. Brewster,et al. Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues. , 2013, International journal of pharmaceutics.
[2] Harsh Chauhan,et al. Correlating the behavior of polymers in solution as precipitation inhibitor to its amorphous stabilization ability in solid dispersions. , 2013, Journal of pharmaceutical sciences.
[3] Po-Chang Chiang,et al. Systemic concentrations can limit the oral absorption of poorly soluble drugs: an investigation of non-sink permeation using physiologically based pharmacokinetic modeling. , 2013, Molecular pharmaceutics.
[4] L. S. Taylor,et al. Liquid–Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs: Implications for Solubility Enhancing Formulations , 2013 .
[5] James D. Litster,et al. Quantitative analysis of the inhibitory effect of HPMC on felodipine crystallization kinetics using population balance modeling , 2013 .
[6] P. Annaert,et al. Drug precipitation-permeation interplay: supersaturation in an absorptive environment. , 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[7] R. Bogner,et al. Solution-mediated phase transformation: significance during dissolution and implications for bioavailability. , 2012, Journal of pharmaceutical sciences.
[8] A. Dokoumetzidis,et al. Elucidating the Role of Dose in the Biopharmaceutics Classification of Drugs: The Concepts of Critical Dose, Effective In Vivo Solubility, and Dose-Dependent BCS , 2012, Pharmaceutical Research.
[9] Alfred Fahr,et al. Drug delivery strategies for poorly water-soluble drugs: the industrial perspective , 2011, Expert opinion on drug delivery.
[10] Stefan Willmann,et al. An update on computational oral absorption simulation , 2011, Expert opinion on drug metabolism & toxicology.
[11] M. Pikal,et al. Solubility advantage of amorphous pharmaceuticals, part 3: Is maximum solubility advantage experimentally attainable and sustainable? , 2011, Journal of pharmaceutical sciences.
[12] R. Bogner,et al. Solution-Mediated Phase Transformation of Haloperidol Mesylate in the Presence of Sodium Lauryl Sulfate , 2011, AAPS PharmSciTech.
[13] Michael J. Pikal,et al. Solubility Advantage of Amorphous Pharmaceuticals: II. Application of Quantitative Thermodynamic Relationships for Prediction of Solubility Enhancement in Structurally Diverse Insoluble Pharmaceuticals , 2010, Pharmaceutical Research.
[14] Na Sun,et al. Dissolution rate and apparent solubility of poorly soluble drugs in biorelevant dissolution media. , 2010, Molecular pharmaceutics.
[15] R. Bogner,et al. Crystallization of amorphous indomethacin during dissolution: effect of processing and annealing. , 2010, Molecular pharmaceutics.
[16] John J Totman,et al. Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome. , 2010, Gastroenterology.
[17] Lynne S. Taylor,et al. Understanding the Behavior of Amorphous Pharmaceutical Systems during Dissolution , 2010, Pharmaceutical Research.
[18] Patrick Augustijns,et al. Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability? , 2009, Journal of pharmaceutical sciences.
[19] Steven C. Sutton,et al. Role of Physiological Intestinal Water in Oral Absorption , 2009, The AAPS Journal.
[20] Sebastian Polak,et al. Population-Based Mechanistic Prediction of Oral Drug Absorption , 2009, The AAPS Journal.
[21] Emma L. McConnell,et al. Meal-Induced Acceleration of Tablet Transit Through the Human Small Intestine , 2009, Pharmaceutical Research.
[22] A. Basit,et al. Gut instincts: explorations in intestinal physiology and drug delivery. , 2008, International journal of pharmaceutics.
[23] J. Dressman,et al. Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update , 2008, Pharmaceutical Research.
[24] H Lennernäs,et al. Intestinal permeability and its relevance for absorption and elimination , 2007, Xenobiotica; the fate of foreign compounds in biological systems.
[25] A. Dokoumetzidis,et al. Predictive models for oral drug absorption: from in silico methods to integrated dynamical models , 2007, Expert opinion on drug metabolism & toxicology.
[26] N. Hosten,et al. Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging , 2005, Alimentary pharmacology & therapeutics.
[27] Panos Macheras,et al. Identification of Biowaivers Among Class II Drugs: Theoretical Justification and Practical Examples , 2004, Pharmaceutical Research.
[28] N. Rodríguez-Hornedo,et al. Surfactant-facilitated crystallization of dihydrate carbamazepine during dissolution of anhydrous polymorph. , 2004, Journal of pharmaceutical sciences.
[29] Shobha N. Bhattachar,et al. Dissolution Behavior of a Poorly Water Soluble Compound in the Presence of Tween 80 , 2003, Pharmaceutical Research.
[30] Panos Macheras,et al. A Population Growth Model of Dissolution , 1997, Pharmaceutical Research.
[31] Kevin C. Johnson,et al. Guidance in the Setting of Drug Particle Size Specifications to Minimize Variability in Absorption , 1996, Pharmaceutical Research.
[32] Hsiu-Ying Yu,et al. Analysis of Tissue Distribution of Valproate in Guinea-Pigs: Evidence for Its Capacity-Limited Tissue Distribution , 1995, Pharmaceutical Research.
[33] J. Crison,et al. A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability , 1995, Pharmaceutical Research.
[34] Gordon L. Amidon,et al. Estimating the Fraction Dose Absorbed from Suspensions of Poorly Soluble Compounds in Humans: A Mathematical Model , 1993, Pharmaceutical Research.
[35] Patrick J. Sinko,et al. Predicting Fraction Dose Absorbed in Humans Using a Macroscopic Mass Balance Approach , 1991, Pharmaceutical Research.
[36] Aditya Mohan Kaushal,et al. Amorphous drug delivery systems: molecular aspects, design, and performance. , 2004, Critical reviews in therapeutic drug carrier systems.
[37] Christos Reppas,et al. Dissolution Testing as a Prognostic Tool for Oral Drug Absorption: Immediate Release Dosage Forms , 2004, Pharmaceutical Research.
[38] Kevin C. Johnson,et al. Dissolution and Absorption Modeling: Model Expansion to Simulate the Effects of Precipitation, Water Absorption, Longitudinally Changing Intestinal Permeability, and Controlled Release on Drug Absorption , 2003, Drug development and industrial pharmacy.
[39] J. Dressman,et al. In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs. , 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[40] W. Curatolo,et al. Physical chemical properties of oral drug candidates in the discovery and exploratory development settings , 1998 .
[41] Lawrence X. Yu,et al. Compartmental transit and dispersion model analysis of small intestinal transit flow in humans , 1996 .
[42] G L Amidon,et al. Novel approach to the analysis of in vitro-in vivo relationships. , 1996, Journal of pharmaceutical sciences.
[43] G L Amidon,et al. Transport approaches to the biopharmaceutical design of oral drug delivery systems: prediction of intestinal absorption. , 1996, Advanced drug delivery reviews.
[44] P. Macheras,et al. Toward a quantitative approach for the prediction of the fraction of dose absorbed using the absorption potential concept. , 1989, Biopharmaceutics & drug disposition.
[45] J. Dressman,et al. Mixing-tank model for predicting dissolution rate control or oral absorption. , 1986, Journal of pharmaceutical sciences.
[46] G. Amidon,et al. Absorption potential: estimating the fraction absorbed for orally administered compounds. , 1985, Journal of pharmaceutical sciences.
[47] G. Amidon,et al. Physicochemical model for dose-dependent drug absorption. , 1984, Journal of pharmaceutical sciences.
[48] B. C. Goodacre,et al. A MATHEMATICAL MODEL OF DRUG ABSORPTION , 1981, Journal of clinical and hospital pharmacy.