Antigen‐specific cytotoxic T cell and antigen‐specific proliferating T cell clones can be induced to cytolytic activity by monoclonal antibodies against T3

T3 is a human differentiation antigen expressed exclusively on mature T cells. In this study it is shown that anti‐T3 monoclonal antibodies, in addition to their capacity to induce T cells to proliferate, are able to induce antigen‐specific cytotoxic T lymphocyte clones to mediate antigen nonspecific cytotoxic activity. It is furthermore shown that anti‐T3 reagents are able to trigger lytic activity in T cell clones characterized as noncytotoxic antigen‐specific proliferating T cells. The data presented indicate that perturbation of T3 can trigger the lytic machinery in cytolytic as well as noncytolytic T cell clones.

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