Presence of P 2 lObcrabl Is Associated with Decreased Expression of a Beta Chemokine CIO Gene in a P 210 bcrabl-Positive Myeloid Leukemia Cell Line

Background: Chronic myelogenous leukemia (CML) is thought to start with the acquisition of the t(9;22) chromosomal translocation that codes for the P2 lObcrabl tyrosine-specific protein kinase. The CML cells exhibit anchorage-independent cell growth and genetic instability. After the initial phase, the cells acquire the phenotype of growth factor-independent growth. After the chronic phase, the disease evolves into the accelerated and blastic phases through the process of sequential random muta-

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