New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety.

[1]  David M. Shackleford,et al.  Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials. , 2021, Journal of medicinal chemistry.

[2]  E. Winzeler,et al.  Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome , 2018, Journal of medicinal chemistry.

[3]  D. Hashizume,et al.  Structures and Synthesis of Hitoyopodins: Bioactive Aromatic Sesquiterpenoids Produced by the Mushroom Coprinopsis cinerea. , 2018, Organic letters.

[4]  F. Diederich,et al.  Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures. , 2017, Journal of medicinal chemistry.

[5]  David W. Gray,et al.  A novel multiple-stage antimalarial agent that inhibits protein synthesis , 2015, Nature.

[6]  H. Osada,et al.  Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity , 2015, Bioscience, biotechnology, and biochemistry.

[7]  Hongshen Ma,et al.  (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium , 2014, Proceedings of the National Academy of Sciences.

[8]  R. Guy,et al.  Antimalarials in development in 2014. , 2014, Chemical reviews.

[9]  David M. Shackleford,et al.  Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. , 2011, Journal of medicinal chemistry.

[10]  Christian Scheurer,et al.  Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria , 2011, Proceedings of the National Academy of Sciences.

[11]  N. Day,et al.  Artemisinin resistance: current status and scenarios for containment , 2010, Nature Reviews Microbiology.

[12]  David A. Fidock,et al.  Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria , 2009, Nature Reviews Microbiology.

[13]  C. Davis,et al.  Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. , 2009, Journal of medicinal chemistry.

[14]  Paul Labute,et al.  The generalized Born/volume integral implicit solvent model: Estimation of the free energy of hydration using London dispersion instead of atomic surface area , 2008, J. Comput. Chem..

[15]  I. Lennon,et al.  A novel synthesis of 5-hydroxy-2,2-dimethyl-10-propyl-2H-pyrano[2,3-f]chromen-8-one , 2002 .

[16]  J. Scheigetz,et al.  AN IMPROVED SYNTHESIS OF ETHYL 4-HYDROXY-3-METHYLBENZOFURAN-2-CARBOXYLATE , 1988 .