Retrospective study of 37 Cavalier King Charles Spaniel dogs diagnosed with Chiari-like malformation and Syringomyelia

Abstract Chiari-like malformation represents a congenital anomaly that affects the bony cranial base and the hindbrain, leading to fluid filled cavities formation in the spinal cord, condition named Syringomyelia. This paper aims to assess the variety of the clinical signs and to evaluate the magnetic resonance imaging findings in thirty- seven Cavalier King Charles Spaniel dogs. The study was performed over a four-year period, from 2013 to 2017, all cases underwent neurological examination, full diagnostic work-up, including magnetic resonance imaging scans of the brain, cervical and upper thoracic spinal cord. Thirty-seven dogs were included in this study, 23 females and 14 males, with a mean age of 3.6±2.1years. The commonest clinical findings encountered were neuropathic pain and vocalization, seen in all 37 cases, followed by scratching, facial rubbing, paw licking, air licking, tail chasing, seizures and unilateral facial paralysis. Different grades of cerebellar herniation and cervical syrinxes were noted in all cases, other magnetic resonance imaging findings encountered were medullary kinking, presyrinx and ventriculomegaly. In establishing the diagnosis of the Chiari-like malformation and Syringomyelia, the breed, clinical history and the symptomatology are very important, but only magnetic resonance imaging technique can provide quantitative assessment of the nervous system lesions.

[1]  S. Moore,et al.  Understanding and Treating Chiari‐like Malformation and Syringomyelia in Dogs , 2018, Topics in companion animal medicine.

[2]  C. Loughin Chiari-like Malformation. , 2016, The Veterinary clinics of North America. Small animal practice.

[3]  U. Westrup,et al.  Prevalence and Heritability of Symptomatic Syringomyelia in Cavalier King Charles Spaniels and Long‐term Outcome in Symptomatic and Asymptomatic Littermates , 2014, Journal of veterinary internal medicine.

[4]  A. Pomianowski,et al.  Syringomyelia and Chiari Malformation in Cavalier King Charles Spaniels – Magnetic Resonance Imaging, Pharmacological and Surgical Treatment , 2013 .

[5]  A. McFadyen,et al.  Effectiveness of breeding guidelines for reducing the prevalence of syringomyelia , 2011, Veterinary Record.

[6]  C. Rusbridge,et al.  Distribution of syringomyelia along the entire spinal cord in clinically affected Cavalier King Charles Spaniels. , 2011, Veterinary journal.

[7]  R. D. da Costa,et al.  Differential diagnosis of spinal diseases. , 2010, The Veterinary clinics of North America. Small animal practice.

[8]  J. Woolliams,et al.  Heritability of syringomyelia in Cavalier King Charles spaniels. , 2010, Veterinary journal.

[9]  C. Rusbridge,et al.  [Chiari-like malformation--syringomyelia in the Cavalier King Charles Spaniel]. , 2009, Tijdschrift voor diergeneeskunde.

[10]  A. McFadyen,et al.  Chiari-like malformation in the Griffon Bruxellois. , 2009, The Journal of small animal practice.

[11]  L. Cauzinille,et al.  Chiari-like malformation and syringomyelia in normal cavalier King Charles spaniels: a multiple diagnostic imaging approach. , 2008, The Journal of small animal practice.

[12]  C. Rusbridge Chiari-like malformation with syringomyelia in the Cavalier King Charles spaniel: long-term outcome after surgical management. , 2007, Veterinary surgery : VS.

[13]  D. Pfeiffer,et al.  Neurological signs and results of magnetic resonance imaging in 40 cavalier King Charles spaniels with Chiari type 1-like malformations , 2003, Veterinary Record.

[14]  J. Osborne,et al.  Morphology of the caudal fossa in Cavalier King Charles Spaniels. , 2009, Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association.