Protease-Activated Receptor 4: A Critical Participator in Inflammatory Response
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[1] Dan Chen,et al. Protease‐activated receptor 4 activation increases the expression of calcitonin gene‐related peptide mRNA and protein in dorsal root ganglion neurons , 2013, Journal of neuroscience research.
[2] Dan Chen,et al. Capsaicin Up-Regulates Protease-Activated Receptor-4 mRNA and Protein in Primary Cultured Dorsal Root Ganglion Neurons , 2013, Cellular and Molecular Neurobiology.
[3] A. Arachiche,et al. Calcium Mobilization And Protein Kinase C Activation Downstream Of Protease Activated Receptor 4 (PAR4) Is Negatively Regulated By PAR3 In Mouse Platelets , 2013, PloS one.
[4] Li Lei,et al. Mitogen-Activated Protein Kinase Pathways are Involved in the Upregulation of Calcitonin Gene-Related Peptide of Rat Trigeminal Ganglion After Organ Culture , 2012, Journal of Molecular Neuroscience.
[5] J. Donnerer,et al. Phosphorylation of ERK1/2 in Dorsal Root Ganglia following Sequential Mustard Oil and Thermal Stimulation of the Rat Hind Paw , 2011, Pharmacology.
[6] T. Lindahl,et al. Protease-activated receptor 1 (PAR1) signalling desensitization is counteracted via PAR4 signalling in human platelets. , 2011, The Biochemical journal.
[7] J. Tajti,et al. Organ culture of the trigeminal ganglion induces enhanced expression of calcitonin gene-related peptide via activation of extracellular signal-regulated protein kinase 1/2 , 2011, Cephalalgia : an international journal of headache.
[8] D. Woulfe,et al. Arrestin-2 Differentially Regulates PAR4 and ADP Receptor Signaling in Platelets* , 2010, The Journal of Biological Chemistry.
[9] A. Morris,et al. A Gi‐independent mechanism mediating Akt phosphorylation in platelets , 2010, Journal of thrombosis and haemostasis : JTH.
[10] T. Yoneda,et al. Acid Activation of Trpv1 Leads to an Up-Regulation of Calcitonin Gene-related Peptide Expression in Dorsal Root Ganglion Neurons via the CaMK-CREB Cascade: A Potential Mechanism of Inflammatory Pain , 2010, Molecular biology of the cell.
[11] V. Vellani,et al. Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones , 2010, Molecular pain.
[12] S. Bradesi. PAR4: A new role in the modulation of visceral nociception , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
[13] M. Steinhoff,et al. Protease‐activated receptor‐4 (PAR4): a role as inhibitor of visceral pain and hypersensitivity , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
[14] F. Casanueva,et al. Obestatin stimulates Akt signalling in gastric cancer cells through beta-arrestin-mediated epidermal growth factor receptor transactivation. , 2009, Endocrine-related cancer.
[15] F. Casanueva,et al. c-Src Regulates Akt Signaling in Response to Ghrelin via β-Arrestin Signaling-Independent and -Dependent Mechanisms , 2009, PloS one.
[16] J. McDougall,et al. Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice. , 2009, Arthritis and rheumatism.
[17] P. Wang,et al. Increases in transient receptor potential vanilloid‐1 mRNA and protein in primary afferent neurons stimulated by protein kinase C and their possible role in neurogenic inflammation , 2009, Journal of neuroscience research.
[18] P. Nicoletti,et al. CGRP receptors in the control of pain and inflammation. , 2009, Current opinion in pharmacology.
[19] S. Kunapuli,et al. Regulation of plasmin-induced protease-activated receptor 4 activation in platelets , 2009, Platelets.
[20] M. Nieman. Protease Activated Receptor-4 (PAR4) Uses Anionic Residues to Interact with α-Thrombin in the Absence or Presence of PAR1. , 2008 .
[21] P. Reitsma,et al. TF:FVIIa‐specific activation of CREB upregulates proapoptotic proteins via protease‐activated receptor‐2 , 2008, Journal of thrombosis and haemostasis : JTH.
[22] A. So,et al. Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation , 2008, Arthritis research & therapy.
[23] Xianglin Shi,et al. Interaction between ERK and GSK3β Mediates Basic Fibroblast Growth Factor-induced Apoptosis in SK-N-MC Neuroblastoma Cells* , 2008, Journal of Biological Chemistry.
[24] D. Woulfe,et al. GSK3beta is a negative regulator of platelet function and thrombosis. , 2008, Blood.
[25] M. Hollenberg,et al. Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more , 2008, British journal of pharmacology.
[26] M. Hollenberg,et al. Proteinase-activated Receptor-2 Induces Cyclooxygenase-2 Expression through β-Catenin and Cyclic AMP-response Element-binding Protein* , 2008, Journal of Biological Chemistry.
[27] M. Hirano,et al. Distinct Ca2+ Requirement for NO Production between Proteinase-Activated Receptor 1 and 4 (PAR1 and PAR4) in Vascular Endothelial Cells , 2007, Journal of Pharmacology and Experimental Therapeutics.
[28] H. Hamm,et al. PAR1, but Not PAR4, Activates Human Platelets through a Gi/o/Phosphoinositide-3 Kinase Signaling Axis , 2007, Molecular Pharmacology.
[29] R. Plevin,et al. Cytokine upregulation of proteinase‐activated‐receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase β in human endothelial cells , 2007, British journal of pharmacology.
[30] A. Malik,et al. Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization , 2007, Proceedings of the National Academy of Sciences.
[31] J. Trejo,et al. Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer , 2007, Journal of Cell Science.
[32] R. Lefkowitz,et al. β-Arrestins and Cell Signaling , 2007 .
[33] M. Steinhoff,et al. Protease‐activated receptor‐4: a novel mechanism of inflammatory pain modulation , 2007, British journal of pharmacology.
[34] H. Hamm,et al. PAR4, but Not PAR1, Signals Human Platelet Aggregation via Ca2+ Mobilization and Synergistic P2Y12 Receptor Activation* , 2006, Journal of Biological Chemistry.
[35] Eric Reiter,et al. GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling , 2006, Trends in Endocrinology & Metabolism.
[36] C. Derian,et al. Blocking the Protease-Activated Receptor 1-4 Heterodimer in Platelet-Mediated Thrombosis , 2006, Circulation.
[37] D. Sommeijer,et al. Soluble tissue factor is a candidate marker for progression of microvascular disease in patients with Type 2 diabetes , 2006, Journal of thrombosis and haemostasis : JTH.
[38] S. Kunapuli,et al. Relative contribution of G-protein-coupled pathways to protease-activated receptor-mediated Akt phosphorylation in platelets. , 2006, Blood.
[39] Qiong Shi,et al. Role of β-arrestin 1 in the metastatic progression of colorectal cancer , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[40] D. Dessem,et al. Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist , 2006, Pain.
[41] M. Hollenberg,et al. Neutrophils and the kallikrein–kinin system in proteinase‐activated receptor 4‐mediated inflammation in rodents , 2005, British journal of pharmacology.
[42] H. Schultheiss,et al. Procoagulant Soluble Tissue Factor Is Released From Endothelial Cells in Response to Inflammatory Cytokines , 2005, Circulation research.
[43] Yi Dai,et al. Expression of mRNA for four subtypes of the proteinase-activated receptor in rat dorsal root ganglia , 2005, Brain Research.
[44] P. Tipping,et al. Reduction of arthritis severity in protease-activated receptor-deficient mice. , 2005, Arthritis and rheumatism.
[45] L. P. de Sousa,et al. Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathway. , 2005, Biochemical and biophysical research communications.
[46] A. Agarwal,et al. PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells , 2005, Cell.
[47] Thomas A Luger,et al. Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. , 2005, Endocrine reviews.
[48] M. Vizzard,et al. Up-regulation of protease activated receptors in bladder after cyclophosphamide induced cystitis and colocalization with capsaicin receptor (VR1) in bladder nerve fibers. , 2005, The Journal of urology.
[49] S. Steinberg. The Cardiovascular Actions of Protease-Activated Receptors , 2005, Molecular Pharmacology.
[50] M. Hollenberg,et al. Proteinase‐activated receptor‐4: evaluation of tethered ligand‐derived peptides as probes for receptor function and as inflammatory agonists in vivo , 2004, British journal of pharmacology.
[51] M. Hetman,et al. Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. , 2004, European journal of biochemistry.
[52] N. Bunnett,et al. Protease-activated receptors: contribution to physiology and disease. , 2004, Physiological reviews.
[53] N. Vergnolle,et al. Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon , 2004, Gut.
[54] D. McKemy,et al. Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. , 2003, Blood.
[55] B. Citron,et al. Persistent Protease-activated Receptor 4 Signaling Mediates Thrombin-induced Microglial Activation* , 2003, Journal of Biological Chemistry.
[56] A. Sabri,et al. Mechanisms of Protease-activated Receptor-4 Actions in Cardiomyocytes , 2003, The Journal of Biological Chemistry.
[57] M. D'Andrea,et al. Expression of protease-activated receptor-1, -2, -3, and -4 in control and experimentally inflamed mouse bladder. , 2003, The American journal of pathology.
[58] S. Coughlin,et al. Protection against thrombosis in mice lacking PAR3. , 2002, Blood.
[59] M. Bokarewa,et al. Intra-articular tissue factor/factor VII complex induces chronic arthritis , 2002, Inflammation Research.
[60] M. D'Andrea,et al. Characterization of Thrombin-Induced Leukocyte Rolling and Adherence: A Potential Proinflammatory Role for Proteinase-Activated Receptor-41 , 2002, The Journal of Immunology.
[61] W. Ruf,et al. Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway , 2002, Science.
[62] J. Baldassare,et al. α-Thrombin Induces Rapid and Sustained Akt Phosphorylation by β-Arrestin1-dependent and -independent Mechanisms, and Only the Sustained Akt Phosphorylation Is Essential for G1 Phase Progression* , 2002, The Journal of Biological Chemistry.
[63] C. Foster,et al. Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling. , 2002, Blood.
[64] D. Zochodne,et al. Proteinase‐activated receptor‐1 agonists attenuate nociception in response to noxious stimuli , 2002, British journal of pharmacology.
[65] P. Andrade-Gordon,et al. Participation of protease‐activated receptor‐1 in thrombin‐induced microglial activation , 2002, Journal of neurochemistry.
[66] M. Silverberg,et al. Pathways for bradykinin formation and inflammatory disease. , 2002, The Journal of allergy and clinical immunology.
[67] James H Morrissey,et al. Tissue factor as a proinflammatory agent , 2002, Arthritis Research & Therapy.
[68] Wei Huang,et al. Role of thrombin signalling in platelets in haemostasis and thrombosis , 2001, Nature.
[69] J. Wallace,et al. Agonists of proteinase‐activated receptor 1 induce plasma extravasation by a neurogenic mechanism , 2001, British journal of pharmacology.
[70] P. Conley,et al. Impaired activation of murine platelets lacking Gαi2 , 2001 .
[71] J. Potempa,et al. Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity. , 2001, Blood.
[72] G. D. Hunter,et al. Proteinase-activated receptors. , 2001, Pharmacological reviews.
[73] W Ruf,et al. Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1. , 2001, Blood.
[74] K. Schrör,et al. Evidence for functionally active protease‐activated receptor‐4 (PAR‐4) in human vascular smooth muscle cells , 2001, British journal of pharmacology.
[75] J. Seckl,et al. Adjuvant‐induced joint inflammation causes very rapid transcription of β‐preprotachykinin and α‐CGRP genes in innervating sensory ganglia , 2001, Journal of neurochemistry.
[76] N. Bunnett,et al. Evidence that PAR‐1 and PAR‐2 mediate prostanoid‐dependent contraction in isolated guinea‐pig gallbladder , 2000, British journal of pharmacology.
[77] B. Ransom,et al. Thrombin‐Induced Activation of Cultured Rodent Microglia , 2000, Journal of neurochemistry.
[78] A. Kawabata,et al. Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease‐activated receptors (PARs): a novel role for PAR‐4 as opposed to PAR‐1 , 2000, British journal of pharmacology.
[79] E. Joe,et al. Thrombin Induces NO Release from Cultured Rat Microglia via Protein Kinase C, Mitogen-activated Protein Kinase, and NF-κB* , 2000, The Journal of Biological Chemistry.
[80] S. Coughlin,et al. Thrombin signalling and protease-activated receptors , 2000, Nature.
[81] V. Hans,et al. Cell activation and inflammatory response following traumatic axonal injury in the rat , 2000, Neuroreport.
[82] S. Coughlin,et al. Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides , 2000, The Journal of Biological Chemistry.
[83] A. Kuliopulos,et al. Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets. , 2000, Biochemistry.
[84] S. Coughlin,et al. PAR3 is a cofactor for PAR4 activation by thrombin , 2000, Nature.
[85] J. Moffatt,et al. Protease-activated receptors: sentries for inflammation? , 2000, Trends in pharmacological sciences.
[86] S. Coughlin,et al. Protease-Activated Receptor 1 Mediates Thrombin-Dependent, Cell-Mediated Renal Inflammation in Crescentic Glomerulonephritis , 2000, The Journal of experimental medicine.
[87] J. Wallace,et al. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism , 2000, Nature Medicine.
[88] H. Grunicke,et al. Novel Membrane-Targeted ERK1 and ERK2 Chimeras Which Act as Dominant Negative, Isotype-Specific Mitogen-Activated Protein Kinase Inhibitors of Ras-Raf-Mediated Transcriptional Activation of c-fos in NIH 3T3 Cells , 1999, Molecular and Cellular Biology.
[89] C. Woolf,et al. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity , 1999, Nature Neuroscience.
[90] S. Kunapuli,et al. Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors. , 1999, The Journal of biological chemistry.
[91] A. Kawabata,et al. Modulation by protease‐activated receptors of the rat duodenal motility in vitro: possible mechanisms underlying the evoked contraction and relaxation , 1999, British journal of pharmacology.
[92] J. Wallace,et al. Characterization of the inflammatory response to proteinase‐activated receptor‐2 (PAR2)‐activating peptides in the rat paw , 1999, British journal of pharmacology.
[93] M. Hollenberg,et al. Proteinase-activated receptor 4 (PAR4): action of PAR4-activating peptides in vascular and gastric tissue and lack of cross-reactivity with PAR1 and PAR2. , 1999, Canadian journal of physiology and pharmacology.
[94] S. Coughlin,et al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. , 1999, The Journal of clinical investigation.
[95] A. Brunet,et al. Nuclear translocation of p42/p44 mitogen‐activated protein kinase is required for growth factor‐induced gene expression and cell cycle entry , 1999, The EMBO journal.
[96] M. Caron,et al. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. , 1999, Science.
[97] Michael Schroeter,et al. Inflammation and glial responses in ischemic brain lesions , 1998, Progress in Neurobiology.
[98] Robert V Farese,et al. A dual thrombin receptor system for platelet activation , 1998, Nature.
[99] P. Mcgeer,et al. The importance of inflammatory mechanisms in alzheimer disease , 1998, Experimental Gerontology.
[100] Scott R. Presnell,et al. Cloning and characterization of human protease-activated receptor 4. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[101] A. Russo,et al. Binding of Upstream Stimulatory Factor and a Cell-specific Activator to the Calcitonin/Calcitonin Gene-related Peptide Enhancer* , 1997, The Journal of Biological Chemistry.
[102] E. Benveniste. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis , 1997, Journal of Molecular Medicine.
[103] D. McDonald,et al. Characterization of Antisera Specific to NK1, NK2, and NK3 Neurokinin Receptors and their Utilization to Localize Receptors in the Rat Gastrointestinal Tract , 1996, The Journal of Neuroscience.
[104] C. Maggi. Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves , 1995, Progress in Neurobiology.
[105] J. Herbert,et al. Thrombin induces endothelial cell growth via both a proteolytic and a non-proteolytic pathway. , 1994, The Biochemical journal.
[106] D. A. Walsh,et al. The effects of calcitonin gene‐related peptide on formation of intra‐articular oedema by inflammatory mediators , 1992, British journal of pharmacology.
[107] J. Blenis,et al. Nuclear localization and regulation of erk- and rsk-encoded protein kinases , 1992, Molecular and cellular biology.
[108] S. Coughlin,et al. Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor , 1992, The Journal of cell biology.
[109] V. Wheaton,et al. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation , 1991, Cell.
[110] H. Schaible,et al. Sensitization of articular afferents to mechanical stimuli by bradykinin , 1989, Pflügers Archiv.
[111] S. Snyder,et al. Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[112] R. Bar-Shavit,et al. Biologic Activities of Nonenzymatic Thrombin: Elucidation of a Macrophage Interactive Domain , 1986, Seminars in thrombosis and hemostasis.
[113] H. Schaible,et al. Activation of fine articular afferent units by bradykinin , 1985, Brain Research.
[114] R. Bar-Shavit,et al. Monocyte chemotaxis: stimulation by specific exosite region in thrombin. , 1983, Science.
[115] W. Dick,et al. STUDIES ON THE RELATIVE EFFECTS OF PROSTAGLANDINS, BRADYKININ, 5‐HYDROXYTRYPTAMINE AND HISTAMINE ON THE SYNOVIAL MICROCIRCULATION IN DOGS , 1976, British journal of pharmacology.
[116] A. Lykke,et al. Increased vascular permeability induced in synovialis of the rat by histamine, serotonin and bradykinin , 1975, Experientia.
[117] J. McDougall,et al. Proteinase-activated receptor-4 (PAR4) activation leads to sensitization of rat joint primary afferents via a bradykinin B2 receptor-dependent mechanism. , 2010, Journal of neurophysiology.
[118] J. Benovic,et al. beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation. , 2009, The Biochemical journal.
[119] J. Baldassare,et al. Alpha-thrombin-mediated phosphatidylinositol 3-kinase activation through release of Gbetagamma dimers from Galphaq and Galphai2. , 2004, The Journal of biological chemistry.
[120] P. Popovich,et al. Immunological regulation of neuronal degeneration and regeneration in the injured spinal cord. , 2000, Progress in brain research.
[121] F. Mulè,et al. Tachykinins mediate noncholinergic excitatory neural responses in the circular muscle of rat proximal colon. , 1998, Canadian journal of physiology and pharmacology.