论文信息 - Tongue hyperpigmentation during interferon therapy

Tongue hyperpigmentation during interferon therapy

Dear Editor, Chronic hepatitis C virus (HCV) infection has been reported in association with some cutaneous disorders such as lichen planus, vasculitis and porphyria cutanea tarda. Also, there have been many cutaneous side-effects of interferon (IFN) treatment such as vasculitis, transient alopecia and trichomegaly. It seems that combination IFN and ribavirin (RBV) causes more toxic skin reactions than IFN alone. Here, we report a woman who developed tongue hyperpigmentation during pegylated (PEG)-IFNa2b and RBV treatment for HCV infection. Mucosal, especially the tongue hyperpigmentation associated with IFN and RBV treatment for HCV infection is rare and has been reported in only 15 patients to date. A 54-year-old woman had been diagnosed with chronic active hepatitis C 2 months prior. The liver biopsy was done and histological activity index (HAI) was 11 and fibrosis score was 2. PEG-IFN-a2b (1.5 mcg ⁄kg once weekly) and RBV (1 g daily) treat-

O. Karabay | N. Goksugur | A. Ogutlu | Aziz Ogutlu

[1] M. Chiu,et al. Lingual hyperpigmentation from pegylated interferon and ribavirin treatment of hepatitis C. , 2010, Journal of American Academy of Dermatology.

[2] C. Noce,et al. Tongue hyperpigmentation resulting from peginterferon alfa and ribavirin combination therapy: a case report. , 2009, Journal of the American Dental Association.

[3] S. Vázquez,et al. Tongue hyperpigmentation resulting from peginterferon alfa‐2a and ribavirin treatment in a Caucasian patient with chronic hepatitis C , 2008, Journal of the European Academy of Dermatology and Venereology : JEADV.

[4] O. Karabay,et al. Eyelash and eyebrow trichomegaly induced by interferon‐alfa 2a , 2007, Clinical and experimental dermatology.

[5] H. Torres,et al. Tongue Hyperpigmentation in a Caucasian Patient Coinfected With HIV and Hepatitis C During Peginterferon Alfa-2b and Ribavirin Therapy , 2007, The American Journal of Gastroenterology.

[6] P. Ferenci,et al. Tongue and Skin Hyperpigmentation During PEG-Interferon-α/Ribavirin Therapy in Dark-Skinned Non-Caucasian Patients with Chronic Hepatitis C , 2006, The American Journal of Gastroenterology.

[7] R. D. de Man,et al. Hyperpigmentation during interferon‐alpha therapy for chronic hepatitis C virus infection , 2003, The British journal of dermatology.