6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression.

[1]  Min Lu,et al.  Potential anxiolytic and antidepressant-like effects of luteolin in a chronic constriction injury rat model of neuropathic pain: Role of oxidative stress, neurotrophins, and inflammatory factors. , 2023, International immunopharmacology.

[2]  Yusuf S. Althobaiti,et al.  Cassia artemisiodes attenuates nociceptive and diabetes-induced neuropathic pain modalities apropos antioxidant and anti-inflammatory mechanisms. , 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[3]  R. Urman,et al.  Flavonoids in the Treatment of Neuropathic Pain , 2021, Current Pain and Headache Reports.

[4]  N. Ullah,et al.  A novel gabapentin analogue assuages neuropathic pain response in chronic sciatic nerve constriction model in rats , 2021, Behavioural Brain Research.

[5]  Magdalena Kocot-Kępska,et al.  Peripheral Mechanisms of Neuropathic Pain—The Role of Neuronal and Non-Neuronal Interactions and Their Implications for Topical Treatment of Neuropathic Pain , 2021, Pharmaceuticals.

[6]  Z. Din,et al.  The antioxidant N-(2-mercaptopropionyl)-glycine (tiopronin) attenuates expression of neuropathic allodynia and hyperalgesia , 2020, Naunyn-Schmiedeberg's Archives of Pharmacology.

[7]  A. Mamun,et al.  Exploring the Promise of Flavonoids to Combat Neuropathic Pain: From Molecular Mechanisms to Therapeutic Implications , 2020, Frontiers in Neuroscience.

[8]  P. Basu,et al.  In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain , 2020, Molecules.

[9]  A. Yordanov,et al.  Aetiology, diagnosis, and clinical management of vulvodynia , 2020, Przeglad menopauzalny = Menopause review.

[10]  R. Treede,et al.  Challenges of neuropathic pain: focus on diabetic neuropathy , 2020, Journal of Neural Transmission.

[11]  V. Fattori,et al.  Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development , 2020, Molecules.

[12]  J. Egido,et al.  The Coming Age of Flavonoids in the Treatment of Diabetic Complications , 2020, Journal of clinical medicine.

[13]  K. Kajo,et al.  Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels , 2019, Biomolecules.

[14]  M. Shahid,et al.  Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy , 2019, BMC Pharmacology and Toxicology.

[15]  I. Ullah,et al.  Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders , 2019, Front. Aging Neurosci..

[16]  E. Feldman,et al.  Diabetic neuropathy , 2019, Nature Reviews Disease Primers.

[17]  M. Shahid,et al.  The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[18]  Hong Wang,et al.  Quercetin alleviates thermal and cold hyperalgesia in a rat neuropathic pain model by inhibiting Toll-like receptor signaling. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[19]  P. Wiffen,et al.  Gabapentin for chronic neuropathic pain in adults. , 2017, The Cochrane database of systematic reviews.

[20]  M. Shahid,et al.  A bacosides containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats , 2017, BMC Complementary and Alternative Medicine.

[21]  N. Islam,et al.  A multi-target therapeutic potential of Prunus domestica gum stabilized nanoparticles exhibited prospective anticancer, antibacterial, urease-inhibition, anti-inflammatory and analgesic properties. , 2017, BMC Complementary and Alternative Medicine.

[22]  M. Shahid,et al.  Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model , 2017, European journal of pain.

[23]  Ashutosh Kumar,et al.  Combination strategy of PARP inhibitor with antioxidant prevent bioenergetic deficits and inflammatory changes in CCI-induced neuropathy , 2017, Neuropharmacology.

[24]  Blair H. Smith,et al.  Risk factors for neuropathic pain in diabetes mellitus , 2016, Pain.

[25]  Baokang Huang,et al.  Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review , 2016, Chemistry & biodiversity.

[26]  A. Thornton,et al.  Current concepts in vulvodynia with a focus on pathogenesis and pain mechanisms , 2016, The Australasian journal of dermatology.

[27]  M. Mühlau,et al.  Prevalence of neuropathic pain in early multiple sclerosis , 2016, Multiple sclerosis.

[28]  H. Emmez,et al.  Effects of quercetin on chronic constriction nerve injury in an experimental rat model , 2016, Acta Neurochirurgica.

[29]  M. Shahid,et al.  Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms , 2016, BMC Complementary and Alternative Medicine.

[30]  G. Deng,et al.  Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy: A systematic review. , 2016, Critical reviews in oncology/hematology.

[31]  P. Wiffen,et al.  Oral nonsteroidal anti-inflammatory drugs for neuropathic pain. , 2015, The Cochrane database of systematic reviews.

[32]  G. Johnston.  Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA , 2015, Neurochemistry International.

[33]  M. Shahid,et al.  A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin , 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

[34]  A. Rauf,et al.  Antinociceptive, muscle relaxant and sedative activities of gold nanoparticles generated by methanolic extract of Euphorbia milii , 2015, BMC Complementary and Alternative Medicine.

[35]  U. Desai,et al.  6-Hydroxyflavone and Derivatives Exhibit Potent Anti-Inflammatory Activity among Mono-, Di- and Polyhydroxylated Flavones in Kidney Mesangial Cells , 2015, PloS one.

[36]  A. Rauf,et al.  Pistacia integerrima gall extract mediated green synthesis of gold nanoparticles and their biological activities , 2015 .

[37]  R. Baron,et al.  Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain , 2014, Nature Reviews Neurology.

[38]  C. Jun,et al.  6-Methoxyflavone Inhibits NFAT Translocation into the Nucleus and Suppresses T Cell Activation , 2014, The Journal of Immunology.

[39]  Chih-Shung Wong,et al.  Baicalin ameliorates neuropathic pain by suppressing HDAC1 expression in the spinal cord of spinal nerve ligation rats. , 2014, Journal of the Formosan Medical Association = Taiwan yi zhi.

[40]  Li Chen,et al.  Liquiritigenin alleviates mechanical and cold hyperalgesia in a rat neuropathic pain model , 2014, Scientific Reports.

[41]  J. Hanrahan,et al.  Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone , 2014, Neurochemical Research.

[42]  L. Sadownik.  Etiology, diagnosis, and clinical management of vulvodynia , 2014, International journal of women's health.

[43]  P. Holzer,et al.  The pharmacology of TRP channels , 2014, British journal of pharmacology.

[44]  S. Kalra,et al.  Vulvodynia: An unrecognized diabetic neuropathic syndrome , 2013, Indian journal of endocrinology and metabolism.

[45]  E. Eisenberg,et al.  Opioids for neuropathic pain. , 2013, The Cochrane database of systematic reviews.

[46]  K. Morita,et al.  The flavonoid quercetin suppreses the development of neuropathic pain behavior in rats: 14AP4-3 , 2013 .

[47]  Blair H. Smith,et al.  Neuropathic pain in the community: More under-treated than refractory? , 2013, PAIN®.

[48]  M. L. Vale,et al.  The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy , 2013, Molecular pain.

[49]  Jun-Xu Li,et al.  Emerging drug targets for pain treatment. , 2012, European journal of pharmacology.

[50]  P. J. Austin,et al.  Chronic constriction of the sciatic nerve and pain hypersensitivity testing in rats. , 2012, Journal of visualized experiments : JoVE.

[51]  S. Bodhankar,et al.  Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats , 2012, Inflammopharmacology.

[52]  Eric M. Francisco,et al.  Altered Central Sensitization in Subgroups of Women With Vulvodynia , 2011, The Clinical journal of pain.

[53]  J. Hanrahan,et al.  Flavonoid modulation of GABAA receptors , 2011, British journal of pharmacology.

[54]  J. Narenjkar,et al.  The Effect of the Flavonoid Quercetin on Pain Sensation in Diabetic Rats , 2011 .

[55]  J. Maroon,et al.  Natural anti-inflammatory agents for pain relief , 2010, Surgical neurology international.

[56]  M. Akamatsu,et al.  Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. , 2009, Bioorganic & medicinal chemistry letters.

[57]  Kay Brune,et al.  Reversal of pathological pain through specific spinal GABAA receptor subtypes , 2008, Nature.

[58]  R. Meyer,et al.  Mechanisms of Neuropathic Pain , 2006, Neuron.

[59]  M. Lacerenza,et al.  Painful peripheral neuropathies. , 2006, Current neuropharmacology.

[60]  Ralf Baron,et al.  Mechanisms of Disease: neuropathic pain—a clinical perspective , 2006, Nature Clinical Practice Neurology.

[61]  R. A’Hern,et al.  Gabapentin is effective in the treatment of cancer-related neuropathic pain: a prospective, open-label study. , 2005, Journal of palliative medicine.

[62]  C. Stannard,et al.  Treatment of chronic pain: antidepressant, antiepileptic and antiarrhythmic drugs , 2005 .

[63]  T. Morrow.  Animal Models of Painful Diabetic Neuropathy: The STZ Rat Model , 2004, Current protocols in neuroscience.

[64]  K. Chopra,et al.  Quercetin, a bioflavonoid, attenuates thermal hyperalgesia in a mouse model of diabetic neuropathic pain , 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[65]  G. Bennett,et al.  Models of neuropathic pain in the rat. , 2003, Current protocols in pharmacology.

[66]  T. Nagao,et al.  Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. , 2002, Biological & pharmaceutical bulletin.

[67]  P. Kam,et al.  Gabapentin: pharmacology and its use in pain management , 2002, Anaesthesia.

[68]  S. Dunnett,et al.  Motor Coordination and Balance in Rodents , 2001, Current protocols in neuroscience.

[69]  M. Rowbotham,et al.  Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. , 1998, JAMA.

[70]  S. McCleary,et al.  Gabapentin (neurontin) and S‐(+)‐3‐isobutylgaba represent a novel class of selective antihyperalgesic agents , 1997, British journal of pharmacology.

[71]  Kwang Jin Kim,et al.  Comparison of three rodent neuropathic pain models , 1997, Experimental Brain Research.

[72]  I. Posso,et al.  Epidemiology of neuropathic pain , 2016 .

[73]  K. Yonenobu,et al.  Prevalence of neuropathic pain in cases with chronic pain related to spinal disorders , 2014, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[74]  Miroslav Backonja,et al.  Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials. , 2003, Clinical therapeutics.