Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy

[1]  Hua Zhou,et al.  A new mechanism for increasing the oral bioavailability of scutellarin with Cremophor EL: Activation of MRP3 with concurrent inhibition of MRP2 and BCRP. , 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[2]  G. Wang,et al.  In vitro and in vivo evaluation of functionalized chitosan-Pluronic micelles loaded with myricetin on glioblastoma cancer. , 2016, Nanomedicine : nanotechnology, biology, and medicine.

[3]  Zhirong Zhang,et al.  Efficient mucus permeation and tight junction opening by dissociable "mucus-inert" agent coated trimethyl chitosan nanoparticles for oral insulin delivery. , 2016, Journal of controlled release : official journal of the Controlled Release Society.

[4]  K. Ye,et al.  NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury , 2015, Proceedings of the National Academy of Sciences.

[5]  Cuifang Cai,et al.  VB12-coated Gel-Core-SLN containing insulin: Another way to improve oral absorption. , 2015, International journal of pharmaceutics.

[6]  M. Oliveira,et al.  An interferon-γ-delivery system based on chitosan/poly(γ-glutamic acid) polyelectrolyte complexes modulates macrophage-derived stimulation of cancer cell invasion in vitro. , 2015, Acta biomaterialia.

[7]  Xi Zhu,et al.  Efficient Peroral Delivery of Insulin via Vitamin B12 Modified Trimethyl Chitosan Nanoparticles. , 2015, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[8]  Jiaji Wang,et al.  Combined Therapy of Diabetic Peripheral Neuropathy with Breviscapine and Mecobalamin: A Systematic Review and a Meta-Analysis of Chinese Studies , 2015, BioMed research international.

[9]  Yuanfeng Wei,et al.  Sustained release and enhanced bioavailability of injectable scutellarin-loaded bovine serum albumin nanoparticles. , 2014, International journal of pharmaceutics.

[10]  Y. Izumi,et al.  Coadministration of Erlotinib and Curcumin Augmentatively Reduces Cell Viability in Lung Cancer Cells , 2014, Phytotherapy research : PTR.

[11]  C. Piccirillo,et al.  Functional dynamics of Foxp3+ regulatory T cells in mice and humans , 2014, Immunological reviews.

[12]  Jingnan Wang,et al.  Cabozantinib Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by a Dual Blockade of VEGFR2 and MET , 2014, Clinical Cancer Research.

[13]  J. Croxatto,et al.  Proliferative retinopathy and neovascularization of the anterior segment in female type 2 diabetic rats , 2013, Diabetology & Metabolic Syndrome.

[14]  Xiaomin Wang,et al.  Attenuation of streptozotocin-induced diabetic retinopathy with low molecular weight fucoidan via inhibition of vascular endothelial growth factor. , 2013, Experimental eye research.

[15]  Liping Chen,et al.  Breviscapine reduces acute lung injury induced by left heart ischemic reperfusion in rats by inhibiting the expression of ICAM-1 and IL-18 , 2013, Experimental and therapeutic medicine.

[16]  M. Laffan,et al.  Von Willebrand Factor, Angiodysplasia and Angiogenesis , 2013, Mediterranean journal of hematology and infectious diseases.

[17]  Romy K. Scheerle,et al.  Metabolism and permeability of curcumin in cultured Caco-2 cells. , 2013, Molecular nutrition & food research.

[18]  V. Šubr,et al.  In Vivo Nanotoxicity Testing using the Zebrafish Embryo Assay. , 2013, Journal of materials chemistry. B.

[19]  H. Sung,et al.  Nanoparticle-induced tight-junction opening for the transport of an anti-angiogenic sulfated polysaccharide across Caco-2 cell monolayers. , 2013, Acta biomaterialia.

[20]  Y. Byun,et al.  Oral drug delivery systems using chemical conjugates or physical complexes. , 2013, Advanced drug delivery reviews.

[21]  Yan Zhao,et al.  Zebrafish: an in vivo model for nano EHS studies. , 2013, Small.

[22]  Anton Blencowe,et al.  Ultrathin chitosan-poly(ethylene glycol) hydrogel films for corneal tissue engineering. , 2013, Acta biomaterialia.

[23]  Yuan-ming Pan,et al.  12-Deoxyphorbol 13-palmitate inhibit VEGF-induced angiogenesis via suppression of VEGFR-2-signaling pathway. , 2013, Journal of ethnopharmacology.

[24]  Y. Liu,et al.  Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) Plays a Key Role in Vasculogenic Mimicry Formation, Neovascularization and Tumor Initiation by Glioma Stem-like Cells , 2013, PloS one.

[25]  Manoj Kumar Singh,et al.  T11TS impedes glioma angiogenesis by inhibiting VEGF signaling and pro-survival PI3K/Akt/eNOS pathway with concomitant upregulation of PTEN in brain endothelial cells , 2013, Journal of Neuro-Oncology.

[26]  A. Tayel,et al.  Evaluation of fungal chitosan as a biocontrol and antibacterial agent using fluorescence-labeling. , 2013, International journal of biological macromolecules.

[27]  Xueqing Yu,et al.  Diabetic retinopathy in predicting diabetic nephropathy in patients with type 2 diabetes and renal disease: a meta-analysis , 2013, Diabetologia.

[28]  Bo Yang,et al.  Scutellarin-cyclodextrin conjugates: synthesis, characterization and anticancer activity. , 2013, Carbohydrate polymers.

[29]  Songyan Zhang,et al.  Scutellarin‐Induced Apoptosis in HepG2 Hepatocellular Carcinoma Cells Via a STAT3 Pathway , 2012, Phytotherapy research : PTR.

[30]  Liqun Yang,et al.  Downregulation of VEGF mRNA expression by triamcinolone acetonide acetate-loaded chitosan derivative nanoparticles in human retinal pigment epithelial cells , 2012, International journal of nanomedicine.

[31]  Jong Oh Kim,et al.  Lipid emulsion as a drug delivery system for breviscapine: Formulation development and optimization , 2012, Archives of Pharmacal Research.

[32]  Bing Yang,et al.  Hyperbranched cationic amylopectin derivatives for gene delivery. , 2012, Biomaterials.

[33]  Robert Rallo,et al.  Automated Phenotype Recognition for Zebrafish Embryo Based In Vivo High Throughput Toxicity Screening of Engineered Nano-Materials , 2012, PloS one.

[34]  J. Schulzke,et al.  The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier. , 2012, Biomaterials.

[35]  Q. Lian,et al.  Effects of breviscapine on pulmonary inflammatory response and lung injury in children undergoing open heart surgery , 2012, Journal of Asian natural products research.

[36]  Kristen M. Jaruszewski,et al.  Chitosan enhances the stability and targeting of immuno-nanovehicles to cerebro-vascular deposits of Alzheimer's disease amyloid protein. , 2012, Nanomedicine : nanotechnology, biology, and medicine.

[37]  J. C. Pickup,et al.  Nano-scale encapsulation enhances allograft survival and function of islets transplanted in a mouse model of diabetes , 2012, Diabetologia.

[38]  Changhao Sun,et al.  Berberine Improves Glucose Homeostasis in Streptozotocin-Induced Diabetic Rats in Association with Multiple Factors of Insulin Resistance , 2011, ISRN endocrinology.

[39]  S. Sivaprasad,et al.  Treatment of proliferative diabetic retinopathy with anti‐VEGF agents , 2011, Acta ophthalmologica.

[40]  Ying Zheng,et al.  Intestinal transport of scutellarein and scutellarin and first-pass metabolism by UDP-glucuronosyltransferase-mediated glucuronidation of scutellarein and hydrolysis of scutellarin , 2011, Xenobiotica; the fate of foreign compounds in biological systems.

[41]  Jun Lu,et al.  Metabolic and pharmacokinetic studies of scutellarin in rat plasma, urine, and feces , 2011, Acta Pharmacologica Sinica.

[42]  Y. Le,et al.  Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Müller cells , 2011, Diabetologia.

[43]  Yanjie Lu,et al.  Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGFβ1 expression and activation of p38‐MAPK and ERK1/2 , 2011, British journal of pharmacology.

[44]  I. Quijada-Garrido,et al.  A novel controlled drug delivery system based on pH-responsive hydrogels included in soft gelatin capsules. , 2010, Acta biomaterialia.

[45]  G. Luo,et al.  PEG-scutellarin prodrugs: synthesis, water solubility and protective effect on cerebral ischemia/reperfusion injury. , 2010, European journal of medicinal chemistry.

[46]  L. Yue,et al.  [Protective effect of breviscapine on cardiac function in children after cardiopulmonary bypass undergoing open heart surgery]. , 2010, Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.

[47]  Maria Jose Alonso,et al.  Chitosan-based nanostructures: a delivery platform for ocular therapeutics. , 2010, Advanced drug delivery reviews.

[48]  Yu Zhang,et al.  Fluorescence Modified Chitosan-Coated Magnetic Nanoparticles for High-Efficient Cellular Imaging , 2009, Nanoscale research letters.

[49]  Taixiang Wu,et al.  Dengzhanhua preparations for acute cerebral infarction. , 2008, The Cochrane database of systematic reviews.

[50]  Q. Ping,et al.  Comparative pharmacokinetics of breviscapine liposomes in dogs, rabbits and rats. , 2008, International journal of pharmaceutics.

[51]  Jun Ren,et al.  Scutellarein inhibits hypoxia- and moderately-high glucose-induced proliferation and VEGF expression in human retinal endothelial cells , 2008, Acta Pharmacologica Sinica.

[52]  R. Simó,et al.  Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy , 2008, Diabetologia.

[53]  M. Alonso-Sande,et al.  Helodermin-loaded nanoparticles: characterization and transport across an in vitro model of the follicle-associated epithelium. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[54]  F. Xiong,et al.  Determination of scutellarin in mouse plasma and different tissues by high-performance liquid chromatography. , 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[55]  M. Cristea,et al.  Exploiting the vitamin B12 pathway to enhance oral drug delivery via polymeric micelles. , 2005, Biomacromolecules.

[56]  Q. Ping,et al.  The Physicochemical Characteristics of Freeze-Dried Scutellarin-Cyclodextrin Tetracomponent Complexes , 2005, Drug development and industrial pharmacy.

[57]  S. Chakrabarti,et al.  Vascular endothelial growth factor in diabetes induced early retinal abnormalities. , 2004, Diabetes research and clinical practice.

[58]  S. Mcdonnell,et al.  Color Doppler ultrasound evaluation of testicular blood flow in stallions. , 2004, Theriogenology.

[59]  N. Chaturvedi,et al.  Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the EURODIAB Prospective Complications Study. , 2003, Diabetes care.

[60]  T. Chowdhury,et al.  The role of serum lipids in exudative diabetic maculopathy: is there a place for lipid lowering therapy? , 2002, Eye.

[61]  H. Jacob,et al.  The newly inbred cohen diabetic rat: a nonobese normolipidemic genetic model of diet-induced type 2 diabetes expressing sex differences. , 2001, Diabetes.

[62]  S. Chakrabarti,et al.  Diabetes-induced vascular dysfunction in the retina: role of endothelins , 1999, Diabetologia.

[63]  P. Artursson,et al.  Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. , 1991, Biochemical and biophysical research communications.

[64]  K. Naruhashi,et al.  Comparison of the expression and function of ATP binding cassette transporters in Caco-2 and T84 cells on stimulation by selected endogenous compounds and xenobiotics. , 2011, Drug metabolism and pharmacokinetics.

[65]  Wei Wei,et al.  Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin. , 2010, Acta biomaterialia.