Inhibition of Toll-like receptors TLR4 and 7 signaling pathways by SIGIRR: a computational approach.

[1]  Database resources of the National Center for Biotechnology Information , 2014, Nucleic Acids Res..

[2]  Shaila C. Rössle,et al.  Homology modeling of human Toll‐like receptors TLR7, 8, and 9 ligand‐binding domains , 2009, Protein science : a publication of the Protein Society.

[3]  M. Shirakawa,et al.  Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling , 2009, Proceedings of the National Academy of Sciences.

[4]  A. Dalpke,et al.  Identification of an N-Terminal Recognition Site in TLR9 That Contributes to CpG-DNA-Mediated Receptor Activation1 , 2009, The Journal of Immunology.

[5]  Hayyoung Lee,et al.  The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex , 2009, Nature.

[6]  N. Gay,et al.  Structure and regulation of cytoplasmic adapter proteins involved in innate immune signaling , 2009, Immunological reviews.

[7]  Janusz M. Bujnicki,et al.  MetaMQAP: A meta-server for the quality assessment of protein models , 2008, BMC Bioinformatics.

[8]  C. Garlanda,et al.  Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens , 2008, The Journal of experimental medicine.

[9]  P. Nordlund,et al.  The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer* , 2008, Journal of Biological Chemistry.

[10]  D. Davies,et al.  Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA , 2008, Science.

[11]  L. McGuffin.  The ModFOLD server for the quality assessment of protein structural models , 2008, Bioinform..

[12]  Grazia Gallo,et al.  Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound , 2007, Journal of leukocyte biology.

[13]  K. Henrick,et al.  Inference of macromolecular assemblies from crystalline state. , 2007, Journal of molecular biology.

[14]  N. Gay,et al.  A Dimer of the Toll-Like Receptor 4 Cytoplasmic Domain Provides a Specific Scaffold for the Recruitment of Signalling Adaptor Proteins , 2007, PloS one.

[15]  B. Monks,et al.  Ligand-induced conformational changes allosterically activate Toll-like receptor 9 , 2007, Nature Immunology.

[16]  N. Gay,et al.  Structure and function of Toll receptors and their ligands. , 2007, Annual review of biochemistry.

[17]  A. Bowie,et al.  The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling , 2007, Nature Reviews Immunology.

[18]  Adeeb H. Rahman,et al.  The role of toll-like receptors in systemic lupus erythematosus , 2006, Springer Seminars in Immunopathology.

[19]  Andrey Tovchigrechko,et al.  GRAMM-X public web server for protein–protein docking , 2006, Nucleic Acids Res..

[20]  R. Medzhitov,et al.  Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling , 2006, Cell.

[21]  C. Jefferies,et al.  MyD88 Adapter-like (Mal) Is Phosphorylated by Bruton's Tyrosine Kinase during TLR2 and TLR4 Signal Transduction* , 2006, Journal of Biological Chemistry.

[22]  S. Fields,et al.  Binding specificity of Toll‐like receptor cytoplasmic domains , 2006, European journal of immunology.

[23]  D. Davies,et al.  The dsRNA binding site of human Toll‐like receptor 3 , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Xiaoxia Li,et al.  SIGIRR Inhibits Interleukin-1 Receptor- and Toll-like Receptor 4-mediated Signaling through Different Mechanisms* , 2005, Journal of Biological Chemistry.

[25]  Liam J. McGuffin,et al.  Protein structure prediction servers at University College London , 2005, Nucleic Acids Res..

[26]  J. Khan,et al.  Crystal Structure of the Toll/Interleukin-1 Receptor Domain of Human IL-1RAPL* , 2004, Journal of Biological Chemistry.

[27]  Robert C. Edgar,et al.  MUSCLE: multiple sequence alignment with high accuracy and high throughput. , 2004, Nucleic acids research.

[28]  Shizuo Akira,et al.  TLR signaling pathways. , 2004, Seminars in immunology.

[29]  András Fiser,et al.  ModLoop: automated modeling of loops in protein structures , 2003, Bioinform..

[30]  N. Gay,et al.  Structural Complementarity of Toll/Interleukin-1 Receptor Domains in Toll-like Receptors and the Adaptors Mal and MyD88* , 2003, Journal of Biological Chemistry.

[31]  C. Garlanda,et al.  Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. , 2003, European cytokine network.

[32]  G. Stark,et al.  SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling , 2003, Nature Immunology.

[33]  Z. Weng,et al.  ZDOCK: An initial‐stage protein‐docking algorithm , 2003, Proteins.

[34]  A. Elofsson,et al.  Can correct protein models be identified? , 2003, Protein science : a publication of the Protein Society.

[35]  Liang Tong,et al.  An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2. , 2002, Biochemical and biophysical research communications.

[36]  H. Berman,et al.  Electronic Reprint Biological Crystallography the Protein Data Bank Biological Crystallography the Protein Data Bank , 2022 .

[37]  L. Tong,et al.  Structural basis for signal transduction by the Toll/interleukin-1 receptor domains , 2000, Nature.

[38]  A. Bowie,et al.  The Interleukin-1 Receptor/toll-like Receptor Superfamily: Signal Generators for Pro-inflammatory Interleukins and Microbial Products , 2022 .

[39]  J. Sims,et al.  Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. , 1999, Cytokine.

[40]  P. Ricciardi-Castagnoli,et al.  Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. , 1998, Science.

[41]  F. Martinon,et al.  MyD88, an Adapter Protein Involved in Interleukin-1 Signaling* , 1998, The Journal of Biological Chemistry.

[42]  J M Thornton,et al.  Successful protein fold recognition by optimal sequence threading validated by rigorous blind testing , 1995, Proteins.

[43]  C. Garlanda,et al.  Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced systemic lupus nephritis , 2010 .

[44]  James A. Cuff,et al.  The Jalview Java alignment editor , 2004, Bioinform..

[45]  A. Sali,et al.  Modeling of loops in protein structures , 2000, Protein science : a publication of the Protein Society.