Daily intake of bisphenol A and potential sources of exposure: 2005–2006 National Health and Nutrition Examination Survey

Nationally representative data on urinary levels of bisphenol A (BPA) and its metabolites in the United States from the 2005–2006 National Health and Nutrition Examination Survey (NHANES) were used to estimate daily BPA intakes. In addition, NHANES data on potential sources of BPA exposure and personal characteristics were explored for their association with urinary BPA levels. On the basis of 2005–2006 NHANES urinary BPA data and assumptions described in this paper, median daily intake for the overall population is approximately 34 ng/kg-day. Median daily BPA intakes for men are statistically significantly higher than for women; there is a significant decrease in daily BPA intake with increasing age. Gender- and age-specific median intakes differ from the overall population by less than a factor of 2. Although estimates of daily BPA intake have decreased compared with those from the 2003–2004 NHANES, it is premature to draw conclusions regarding trends at this time, as there is no indication that BPA use declined from 2003 to 2006. On the basis of an assessment of urinary BPA and questionnaire data from the 2005–2006 NHANES, consumption of soda, school lunches, and meals prepared outside the home — but not bottled water or canned tuna — was statistically significantly associated with higher urinary BPA.

[1]  E. Peralta,et al.  Migration of bisphenol A (BPA) from can coatings into a fatty-food simulant and tuna fish , 2005, Food additives and contaminants.

[2]  V. Padmanabhan,et al.  Bisphenol-A and disparities in birth outcomes: a review and directions for future research , 2010, Journal of Perinatology.

[3]  Hermann Fromme,et al.  Determination of free and total bisphenol A in human urine to assess daily uptake as a basis for a valid risk assessment. , 2008, Toxicology letters.

[4]  H. Makino,et al.  Determination of Bisphenol A in Effluents of Hemodialyzers , 2001, Nephron.

[5]  S. Tsugane,et al.  Long-term study of urinary bisphenol A in elementary school children , 2008, Environmental health and preventive medicine.

[6]  F. Toldrá,et al.  Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission , 2005 .

[7]  J. Valentin Basic anatomical and physiological data for use in radiological protection: reference values , 2002, Annals of the ICRP.

[8]  Jane A Hoppin,et al.  Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa). , 2009, International journal of hygiene and environmental health.

[9]  Antonia M. Calafat,et al.  Exposure to Bisphenol A and Other Phenols in Neonatal Intensive Care Unit Premature Infants , 2008, Environmental health perspectives.

[10]  Laura N. Vandenberg,et al.  Human exposure to bisphenol A (BPA). , 2007, Reproductive toxicology.

[11]  M. Wittassek,et al.  GerES IV: phthalate metabolites and bisphenol A in urine of German children. , 2009, International journal of hygiene and environmental health.

[12]  Wolfgang Völkel,et al.  Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures. , 2008, Toxicology and applied pharmacology.

[13]  L. Barraj,et al.  Environmental chemicals in people: challenges in interpreting biomonitoring information. , 2008, Journal of environmental health.

[14]  A. Granada,et al.  Dietary exposure assessment of pregnant women to bisphenol-A from cans and microwave containers in Southern Spain. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[15]  Karin B. Michels,et al.  Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations , 2009, Environmental health perspectives.

[16]  J. Bucher Bisphenol A: Where to Now? , 2009, Environmental health perspectives.

[17]  Ross Ihaka,et al.  Gentleman R: R: A language for data analysis and graphics , 1996 .

[18]  D. Naiman,et al.  Bisphenol A (BPA) daily intakes in the United States: Estimates from the 2003–2004 NHANES urinary BPA data , 2008, Journal of Exposure Science and Environmental Epidemiology.

[19]  Antonia M. Calafat,et al.  Exposure of the U.S. Population to Bisphenol A and 4-tertiary-Octylphenol: 2003–2004 , 2007, Environmental health perspectives.

[20]  Chunhua Wu,et al.  Bisphenol A levels in blood and urine in a Chinese population and the personal factors affecting the levels. , 2009, Environmental research.

[21]  A. Calafat,et al.  Temporal Variability and Predictors of Urinary Bisphenol A Concentrations in Men and Women , 2007, Environmental health perspectives.

[22]  E. Component Documentation, Codebook, and Frequencies , 2006 .

[23]  D. Naiman,et al.  Public health interpretation of trihalomethane blood levels in the United States: NHANES 1999–2004 , 2010, Journal of Exposure Science and Environmental Epidemiology.

[24]  Xu-Liang Cao,et al.  Levels of bisphenol A in canned soft drink products in Canadian markets. , 2009, Journal of agricultural and food chemistry.