hCG, the wonder of today's science

[1]  L. Cole,et al.  Hyperglycosylated hCG, hCGβ and Hyperglycosylated hCGβ: Interchangeable cancer promoters , 2012, Molecular and Cellular Endocrinology.

[2]  L. Cole hCG, five independent molecules. , 2012, Clinica chimica acta; international journal of clinical chemistry.

[3]  L. Cole,et al.  Total hCG tests. , 2011, Clinica chimica acta; international journal of clinical chemistry.

[4]  K. Blackwell,et al.  Phase I Study Utilizing a Novel Antigen-Presenting Cell–Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients , 2011, Clinical Cancer Research.

[5]  L. Cole Individual deviations in human chorionic gonadotropin concentrations during pregnancy. , 2011, American journal of obstetrics and gynecology.

[6]  R. Iles,et al.  Biological Function of the Free β-Subunit: Expression and Treatment Target in Cancer , 2010 .

[7]  J. Guibourdenche,et al.  Hyperglycosylated hCG is a marker of early human trophoblast invasion. , 2010, The Journal of clinical endocrinology and metabolism.

[8]  Neil J Sebire,et al.  Gestational trophoblastic disease , 2010, The Lancet.

[9]  L. Cole,et al.  USA hCG reference service, 10-year report. , 2010, Clinical biochemistry.

[10]  J. Foidart,et al.  Human chorionic gonadotropin: a hormone with immunological and angiogenic properties. , 2010, Journal of reproductive immunology.

[11]  J. Foidart,et al.  Chorionic gonadotropin stimulation of angiogenesis and pericyte recruitment. , 2009, The Journal of clinical endocrinology and metabolism.

[12]  H. Volk,et al.  Human Chorionic Gonadotropin Attracts Regulatory T Cells into the Fetal-Maternal Interface during Early Human Pregnancy1 , 2009, The Journal of Immunology.

[13]  L. Cole,et al.  Production of human chorionic gonadotropin during the normal menstrual cycle. , 2009, The Journal of reproductive medicine.

[14]  L. Cole,et al.  The quagmire of hCG and hCG testing in gynecologic oncology. , 2009, Gynecologic oncology.

[15]  D. Coppola,et al.  Purified human chorionic gonadotropin induces apoptosis in breast cancer , 2008, Molecular Cancer Therapeutics.

[16]  L. Cole,et al.  Evolution of the human brain, chorionic gonadotropin and hemochorial implantation of the placenta: insights into origins of pregnancy failures, preeclampsia and choriocarcinoma. , 2008, The Journal of reproductive medicine.

[17]  L. Cole,et al.  Hyperglycosylated human chorionic gonadotropin and the source of pregnancy failures. , 2008, Fertility and sterility.

[18]  J. Schaffer,et al.  Bilateral ureteric obstruction of a partially duplicated collecting system improves after surgical correction of procidentia: a case report. , 2008, The Journal of reproductive medicine.

[19]  L. Sokoll,et al.  Use of serum FSH to identify perimenopausal women with pituitary hCG. , 2008, Clinical chemistry.

[20]  I. Laurendeau,et al.  Human Chorionic Gonadotropin Produced by the Invasive Trophoblast But Not the Villous Trophoblast Promotes Cell Invasion and Is Down-Regulated by Peroxisome Proliferator-Activated Receptor-γ , 2007 .

[21]  J. Foidart,et al.  Dialogue between Blastocyst hCG and Endometrial LH/hCG Receptor: Which Role in Implantation? , 2007, Gynecologic and Obstetric Investigation.

[22]  R. Benner,et al.  Chorionic gonadotropin can enhance innate immunity by stimulating macrophage function , 2007, Journal of leukocyte biology.

[23]  C. Rao,et al.  The past, present and future of nongonadal LH/hCG actions in reproductive biology and medicine , 2007, Molecular and Cellular Endocrinology.

[24]  K. Preissner,et al.  HCG in the regulation of placental angiogenesis. Results of an in vitro study. , 2007, Placenta.

[25]  R. Iles,et al.  Ectopic hCGβ expression by epithelial cancer: Malignant behaviour, metastasis and inhibition of tumor cell apoptosis , 2007, Molecular and Cellular Endocrinology.

[26]  P. J. Delves,et al.  Designing a new generation of anti-hCG vaccines for cancer therapy , 2007, Molecular and Cellular Endocrinology.

[27]  C. Karlsson,et al.  Human chorionic gonadatropin (hCG) during third trimester pregnancy , 2007, Scandinavian journal of clinical and laboratory investigation.

[28]  L. Cole,et al.  Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG. , 2006, Gynecologic oncology.

[29]  C. Rao Physiological and Pathological Relevance of Human Uterine LH/hCG Receptors , 2006, The Journal of the Society for Gynecologic Investigation: JSGI.

[30]  L. Cole "Background" human chorionic gonadotropin in healthy, nonpregnant women. , 2005, Clinical chemistry.

[31]  Shannon Haymond,et al.  Diagnostic considerations in the measurement of human chorionic gonadotropin in aging women. , 2005, Clinical chemistry.

[32]  T. Maruo,et al.  Transfection of antisense chorionic gonadotropin beta gene into choriocarcinoma cells suppresses the cell proliferation and induces apoptosis. , 2005, The Journal of clinical endocrinology and metabolism.

[33]  C. Metz,et al.  Marked increase in macrophage migration inhibitory factor synthesis and secretion in human endometrial cells in response to human chorionic gonadotropin hormone. , 2005, The Journal of clinical endocrinology and metabolism.

[34]  M. Zafarullah,et al.  TGF‐β‐induced expression of tissue inhibitor of metalloproteinases‐3 gene in chondrocytes is mediated by extracellular signal‐regulated kinase pathway and Sp1 transcription factor , 2005, Journal of cellular physiology.

[35]  J. Connolly,et al.  A Novel Human Cancer Vaccine Elicits Cellular Responses to the Tumor-Associated Antigen, Human Chorionic Gonadotropin β , 2004, Clinical Cancer Research.

[36]  S. Nakajima,et al.  Human fetal nongonadal tissues contain human chorionic gonadotropin/luteinizing hormone receptors. , 2004, The Journal of clinical endocrinology and metabolism.

[37]  M. Laub,et al.  Identification of the anthelix motif in the TGF‐β superfamily by molecular 3D‐Rapid Prototyping , 2003 .

[38]  L. Cole,et al.  Hyperglycosylated hCG (invasive trophoblast antigen, ITA) a key antigen for early pregnancy detection. , 2003, Clinical biochemistry.

[39]  R. Iles,et al.  Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection? , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[40]  K. Münstedt,et al.  Angiogenesis and vasculogenesis in pregnancy. , 2003, European journal of obstetrics, gynecology, and reproductive biology.

[41]  Terry J. Smith,et al.  Human chorionic gonadotrophin relaxation of human pregnant myometrium and activation of the BKCa channel. , 2003, The Journal of clinical endocrinology and metabolism.

[42]  R. Martin,et al.  Human reproduction: a comparative background for medical hypotheses. , 2003, Journal of reproductive immunology.

[43]  P. Iversen,et al.  Monoclonal antibodies to two epitopes of beta-human chorionic gonadotropin for the treatment of cancer. , 2003, Current opinion in molecular therapeutics.

[44]  N. Kanayama,et al.  Anti-Macrophage Inhibitory Factor Antibody Inhibits PMSG-hCG-Induced Follicular Growth and Ovulation in Mice , 2002, Journal of Assisted Reproduction and Genetics.

[45]  K. Preissner,et al.  Characterization of human chorionic gonadotropin as a novel angiogenic factor. , 2002, The Journal of clinical endocrinology and metabolism.

[46]  O. Genbačev,et al.  Trophoblast origin of hCG isoforms: cytotrophoblasts are the primary source of choriocarcinoma-like hCG , 2002, Molecular and Cellular Endocrinology.

[47]  P. Iversen,et al.  Active Specific Immunotherapy with a β-Human Chorionic Gonadotropin Peptide Vaccine in Patients with Metastatic Colorectal Cancer: Antibody Response Is Associated with Improved Survival , 2002 .

[48]  L. Cole,et al.  The role of hyperglycosylated hCG in trophoblast invasion and the prediction of subsequent pre‐eclampsia , 2002, Prenatal diagnosis.

[49]  M. Ruvolo,et al.  Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. , 2002, Molecular biology and evolution.

[50]  S. Fisher,et al.  Implantation and the survival of early pregnancy. , 2001, The New England journal of medicine.

[51]  A. Fazleabas,et al.  The role of chorionic gonadotropin (CG) in blastocyst implantation. , 2001, Archives of medical research.

[52]  S. Nakajima,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society The Presence of Functional Luteinizing , 2022 .

[53]  A. Mantingh,et al.  Urinary hyperglycosylated hCG in first trimester screening for chromosomal abnormalities , 2000, Prenatal diagnosis.

[54]  G. Simoni,et al.  Not so inefficient reproduction , 2000, The Lancet.

[55]  D. Dearnaley,et al.  The utility of tumour markers in assessing the response to chemotherapy in advanced bladder cancer , 2000, British Journal of Cancer.

[56]  S. Mathieu,et al.  The increase in bladder carcinoma cell population induced by the free beta subunit of human chorionic gonadotrophin is a result of an anti-apoptosis effect and not cell proliferation , 2000, British Journal of Cancer.

[57]  L. Cole,et al.  Hyperglycosylated human chorionic gonadotropin (invasive trophoblast antigen) immunoassay: A new basis for gestational Down syndrome screening. , 1999, Clinical chemistry.

[58]  E. Jauniaux,et al.  Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited. , 1999, American journal of obstetrics and gynecology.

[59]  L. Pelliniemi,et al.  Evidence for the presence of luteinizing hormone-chorionic gonadotrophin receptors in the pig umbilical cord. , 1999, Journal of reproduction and fertility.

[60]  G. Kovalevskaya,et al.  Differential urinary gonadotrophin profiles in early pregnancy and early pregnancy loss , 1998, Prenatal diagnosis.

[61]  A. Gibbons,et al.  Solving the Brain's Energy Crisis , 1998, Science.

[62]  L. Cole,et al.  Carbohydrate and peptide structure of the α- and β-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma , 1997, Endocrine.

[63]  A. Colao,et al.  Prolactinomas apparently resistant to quinagolide respond to cabergoline therapy. , 1997, The Journal of clinical endocrinology and metabolism.

[64]  P. Lavie,et al.  Immunocytochemical Localization of Gonadotropin and Gonadal Steroid Receptors in Human Pineal Glandsd , 1997 .

[65]  S. Han,et al.  Homologous down-regulation of luteinizing hormone/chorionic gonadotropin receptors by increasing the degradation of receptor transcripts in human uterine endometrial stromal cells. , 1997, Biology of reproduction.

[66]  V. Paradis,et al.  Malignant transformation of nontrophoblastic cells is associated with the expression of chorionic gonadotropin beta genes normally transcribed in trophoblastic cells. , 1997, Cancer research.

[67]  M. Fields,et al.  A cellular and endocrine characterization of the original and induced corpus luteum after administration of a gonadotropin-releasing hormone agonist or human chorionic gonadotropin on day five of the estrous cycle. , 1996, Journal of animal science.

[68]  R. Martin Scaling of the Mammalian Brain: the Maternal Energy Hypothesis , 1996 .

[69]  J. Sinkovics,et al.  Human chorionic gonadotropin‐beta subunit gene expression in cultured human fetal and cancer cells of different types and origins , 1996, Cancer.

[70]  S. Birken,et al.  Isolation and characterization of human pituitary chorionic gonadotropin. , 1996, Endocrinology.

[71]  L. Cole,et al.  β-Core Fragment (β-Core/UGF/UGP), a Tumor Marker: A 7-Year Report , 1996 .

[72]  T. Chard,et al.  The effects of beta-human chorionic gonadotrophin on the in vitro growth of bladder cancer cell lines. , 1996, British Journal of Cancer.

[73]  W. Regelson Have we found the “definitive cancer biomarker”?. The diagnostic and therapeutic implications of human chorionic gonadotropin‐beta expression as a key to malignancy , 1995, Cancer.

[74]  R. Hartsock,et al.  Human chorionic gonadotropin‐beta subunit gene expression in cultured human fetal and cancer cells of different types and origins , 1995, Cancer.

[75]  C. Rao,et al.  Expression of epidermal growth factor, transforming growth factor-alpha, and their common receptor genes in human umbilical cords. , 1995, The Journal of clinical endocrinology and metabolism.

[76]  C. Rao,et al.  Direct regulation of human myometrial contractions by human chorionic gonadotropin. , 1994, The Journal of clinical endocrinology and metabolism.

[77]  C. Rao,et al.  Human myometrial chorionic gonadotropin/luteinizing hormone receptors in preterm and term deliveries. , 1994, The Journal of clinical endocrinology and metabolism.

[78]  J. Spinnato,et al.  Expression of functional human chorionic gonadotropin/human luteinizing hormone receptor gene in human uterine arteries. , 1994, The Journal of clinical endocrinology and metabolism.

[79]  B. Bastide,et al.  Gap junctional communication during human trophoblast differentiation: influence of human chorionic gonadotropin. , 1994, Endocrinology.

[80]  D. C. Harris,et al.  Crystal structure of human chorionic gonadotropin , 1994, Nature.

[81]  C. Rao,et al.  Novel expression of functional human chorionic gonadotropin/luteinizing hormone receptor gene in human umbilical cords. , 1993, The Journal of clinical endocrinology and metabolism.

[82]  C. Rao,et al.  Novel coexpression of human chorionic gonadotropin (hCG)/human luteinizing hormone receptors and their ligand hCG in human fallopian tubes. , 1993, The Journal of clinical endocrinology and metabolism.

[83]  M. Irahara,et al.  Immunosuppressive 30-kDa protein in urine of pregnant women and patients with trophoblastic diseases. , 1993, European journal of obstetrics, gynecology, and reproductive biology.

[84]  S. Cunnane,et al.  The Importance of Energy and Nutrient Supply in Human Brain Evolution , 1993, Nutrition and health.

[85]  P. Licht,et al.  Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain. , 1993, Endocrinology.

[86]  J. Lin,et al.  Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblasts. , 1993, Endocrinology.

[87]  L. Cole,et al.  The deactivation of hCG by nicking and dissociation. , 1993, The Journal of clinical endocrinology and metabolism.

[88]  Rao,et al.  The expression of human chorionic gonadotropin/luteinizing hormone receptors in human endometrial and myometrial blood vessels. , 1992, The Journal of clinical endocrinology and metabolism.

[89]  R. Hartsock,et al.  Flow cytometry method for the analysis of membrane‐associated human chorionic gonadotropin, its subunits, and fragments on human cancer cells , 1992, Cancer.

[90]  L. Cole,et al.  The heterogeneity of human chorionic gonadotropin (hCG). III. The occurrence and biological and immunological activities of nicked hCG. , 1991, Endocrinology.

[91]  G. Bepler,et al.  Human chorionic gonadotropin and related glycoprotein hormones in lung cancer cell lines. , 1991, Cancer letters.

[92]  M. Okamura,et al.  [Characterization of immunoreactive hCG beta-subunit in cultured fluids of the cell lines derived from gynecologic malignant tumors]. , 1990, Nihon Sanka Fujinka Gakkai zasshi.

[93]  C. Weinberg,et al.  Risk Factors for Early Pregnancy Loss , 1990, Epidemiology.

[94]  N. Chegini,et al.  The presence of gonadotropin receptors in nonpregnant human uterus, human placenta, fetal membranes, and decidua. , 1990, The Journal of clinical endocrinology and metabolism.

[95]  R. Ohlsson,et al.  Blastocyst implantation precedes induction of insulin-like growth factor II gene expression in human trophoblasts. , 1989, Development.

[96]  J. Campain,et al.  Chorionic gonadotropin synthesis by human tumor cell lines: examination of subunit accumulation, steady-state levels of mRNA, and gene structure. , 1989, Biochimica et biophysica acta.

[97]  S. Lehnert,et al.  Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action. , 1988, Development.

[98]  L. Cole,et al.  Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system. I. Sensitivity and specificity, comparison with other markers. , 1988, Gynecologic oncology.

[99]  L. Cole The O-linked oligosaccharide structures are striking different on pregnancy and choriocarcinoma HCG. , 1987, The Journal of clinical endocrinology and metabolism.

[100]  J. Heath,et al.  Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. , 1987, The EMBO journal.

[101]  C. Bambra Purification and properties of baboon chorionic gonadotrophin. , 1987, Journal of reproduction and fertility.

[102]  K. Isselbacher,et al.  Ectopic beta-human chorionic gonadotropin production by a human hepatoma cell line (FOCUS): isolation and immunochemical characterization. , 1987, Endocrinology.

[103]  E. Siris,et al.  Use of a highly sensitive and specific immunoradiometric assay for detection of human chorionic gonadotropin in urine of normal, nonpregnant, and pregnant individuals. , 1984, The Journal of clinical endocrinology and metabolism.

[104]  T. Nandedkar,et al.  Effects of intrauterine instillation of antiserum to hCG during early pregnancy in mice. , 1984, Acta endocrinologica.

[105]  Y. Udagawa,et al.  [Biological properties of two newly established cell lines (SKG-3a,3b) from a human uterine cervical epidermoid carcinoma]. , 1984, Nihon Sanka Fujinka Gakkai zasshi.

[106]  R. W. Kuhn,et al.  Cellular localization of chorionic gonadotropin in human fetal kidney and liver. , 1983, The Journal of clinical endocrinology and metabolism.

[107]  L. Cole,et al.  Detection of the free beta subunit of human chorionic gonadotropin (HCG) in cultures of normal and malignant trophoblast cells, pregnancy sera, and sera of patients with choriocarcinoma. , 1983, Endocrinology.

[108]  L. Cole,et al.  ABSENCE OF THE COOH-TERMINAL PEPTIDE ON ECTOPIC HUMAN CHORIONIC GONADOTROPIN B-SUBUNIT (hCGB) , 1982 .

[109]  R. Martin,et al.  Relative brain size and basal metabolic rate in terrestrial vertebrates , 1981, Nature.

[110]  R. W. Kuhn,et al.  Fetal tissue can synthesize a placental hormone. Evidence for chorionic gonadotropin beta-subunit synthesis by human fetal kidney. , 1981, The Journal of clinical investigation.

[111]  B. Nisula,et al.  Metabolic and renal clearance rates of purified human chorionic gonadotropin. , 1981, The Journal of clinical investigation.

[112]  B. Weintraub,et al.  Stimulation of N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate of ectopic production of the free beta subunit of chorionic gonadotropin by a human brain tumor cell line. , 1980, Cancer research.

[113]  J. Fiddes,et al.  The cDNA for the β-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3′-untranslated region , 1980, Nature.

[114]  B. Madsen,et al.  Spare Receptors , 1979, Clinical and experimental pharmacology & physiology.

[115]  F. Noonan,et al.  Early pregnancy factor is immunosuppressive , 1979, Nature.

[116]  W. Engel,et al.  HCG-binding capacity of the rat ovary during pregnancy. , 1977, Acta endocrinologica.

[117]  R. Canfield,et al.  The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit. , 1975, The Journal of biological chemistry.

[118]  G T Ross,et al.  A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormone. , 1972, American journal of obstetrics and gynecology.

[119]  G. Ross,et al.  Ovarian physiology: relationship between plasma LH and steroidogenesis by the follicle and corpus luteum; effect of HCG. , 1969, The Journal of clinical endocrinology and metabolism.

[120]  D. Goldstein,et al.  A radioimmunoassay method for human pituitary luteinizing hormone (LH) and human chorionic gonadotropic (HCG) using 125-I-labeled LH. , 1967, American journal of obstetrics and gynecology.

[121]  L. Wide,et al.  An immunological pregnancy test. , 1960, Acta endocrinologica.

[122]  M. Friedman,et al.  A Simple, Rapid Procedure for the Laboratory Diagnosis of Early Pregnancies , 1931 .

[123]  B. Zondek,et al.  Das Hormon des Hypophysenvorderlappens , 1927, Klinische Wochenschrift.

[124]  B. Aschner Über die Funktion der Hypophyse , 1912, Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere.

[125]  C. Rao 11 – Paradigm Shift on the Targets of hCG Actions , 2010 .

[126]  Y. Marunaka,et al.  New Concept of Spare Receptors and Effectors , 2004, The Journal of Membrane Biology.

[127]  S. Perrier d’Hauterive [Implantation: the first maternal-embryo crosstalk]. , 2004, Journal de gynecologie, obstetrique et biologie de la reproduction.

[128]  L. Wildt,et al.  On the Role of Human Chorionic Gonadotropin (hCG) in the Embryo-Endometrial Microenvironment: Implications for Differentiation and Implantation , 2001, Seminars in reproductive medicine.

[129]  C. Rao,et al.  An Overview of the Past, Present, and Future of Nongonadal LH/hCG Actions in Reproductive Biology and Medicine , 2001, Seminars in reproductive medicine.

[130]  E. Jauniaux,et al.  HCG concentration and receptor gene expression in placental tissue from trisomy 18 and 21. , 2000, Molecular human reproduction.

[131]  L. Cole,et al.  Hyperglycosylated hCG (Invasive Trophoblast Antigen) Immunoassay: a New Basis for Gestational Down Syndrome Screening , 2000 .

[132]  P. Triozzi,et al.  Human chorionic gonadotropin as a target for cancer vaccines. , 1999, Oncology reports.

[133]  C. Rao,et al.  New Understanding in the Biochemistry of Implantation: Potential Direct Roles of Luteinizing Hormone and Human Chorionic Gonadotropin , 1997 .

[134]  C. Rao Immunocytochemical localization of gonadotropin and gonadal steroid receptors in human pineal glands. , 1997, Journal of Clinical Endocrinology and Metabolism.

[135]  L. Cole,et al.  Beta-core fragment (beta-core/UGF/UGP), a tumor marker: a 7-year report. , 1996, Gynecologic oncology.

[136]  R. Pijnenborg THE PLACENTAL BED , 1996 .

[137]  R. de Hertogh,et al.  Rapid, automated quantification of total human chorionic gonadotropin in serum by a chemiluminescent enzyme immunometric assay. , 1995, Clinical chemistry.

[138]  G. Tregear,et al.  The nucleotide sequences of baboon chorionic gonadotropin beta-subunit genes have diverged from the human. , 1986, Gene.

[139]  A. Gupta,et al.  Pregnancy specific proteins: suppression of in vitro blastogenic response to mitogen by these proteins. , 1982, International journal of fertility.

[140]  W. Luckett Comparative development and evolution of the placenta in primates. , 1974, Contributions to primatology.

[141]  Luckett Wp Comparative development and evolution of the placenta in primates. , 1974, Contributions to primatology.