SGLT2 Inhibitors and Their Mode of Action in Heart Failure—Has the Mystery Been Unravelled?
暂无分享,去创建一个
[1] P. Light,et al. Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin , 2021, Circulation.
[2] G. Filippatos,et al. Empagliflozin in Patients With Heart Failure, Reduced Ejection Fraction, and Volume Overload: EMPEROR-Reduced Trial. , 2021, Journal of the American College of Cardiology.
[3] D. Newby,et al. Sodium-glucose co-transporter 2 inhibitor therapy: mechanisms of action in heart failure , 2021, Heart.
[4] Mark E. Anderson,et al. Loss of CASK Accelerates Heart Failure Development , 2021, Circulation research.
[5] S. Daskalopoulou,et al. Systematic review and meta-analysis: SGLT2 inhibitors, blood pressure and cardiovascular outcomes , 2021, International journal of cardiology. Heart & vasculature.
[6] M. Böhm,et al. Empagliflozin does not change cardiac index nor systemic vascular resistance but rapidly improves left ventricular filling pressure in patients with type 2 diabetes: a randomized controlled study , 2021, Cardiovascular Diabetology.
[7] S. Sossalla,et al. A mechanistic rationale for the investigation of sodium–glucose co‐transporter 2 inhibitors in heart failure with preserved ejection fraction. Letter regarding the article ‘Baseline characteristics of patients with heart failure with preserved ejection fraction in the EMPEROR‐Preserved trial’ , 2020, European journal of heart failure.
[8] M. Petrie,et al. EMPEROR-REDUCED reigns while EMPERIAL whimpers. , 2020, European heart journal.
[9] Akshay S. Desai,et al. Effect of empagliflozin on exercise ability and symptoms in heart failure patients with reduced and preserved ejection fraction, with and without type 2 diabetes. , 2020, European heart journal.
[10] G. Filippatos,et al. Efficacy and safety of SGLT2 inhibitors in heart failure: systematic review and meta‐analysis , 2020, ESC heart failure.
[11] Deepak L. Bhatt,et al. Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure. , 2020, The New England journal of medicine.
[12] Y. Jang,et al. Randomized, Controlled Trial to Evaluate the Effect of Dapagliflozin on Left Ventricular Diastolic Function in Patients With Type 2 Diabetes Mellitus: The IDDIA Trial. , 2020, Circulation.
[13] J. McMurray,et al. Effect of Empagliflozin on Left Ventricular Volumes in Patients With Type 2 Diabetes, or Prediabetes, and Heart Failure With Reduced Ejection Fraction (SUGAR-DM-HF) , 2020, Circulation.
[14] V. Fuster,et al. Randomized Trial of Empagliflozin in Non-Diabetic Patients with Heart Failure and Reduced Ejection Fraction. , 2020, Journal of the American College of Cardiology.
[15] M. Böhm,et al. Empagliflozin does not change cardiac index nor systemic vascular resistance but rapidly improves left ventricular filling pressure in patients with type 2 diabetes: a randomized controlled study , 2020 .
[16] M. Shattock,et al. Off-target effects of sodium-glucose co-transporter 2 blockers: empagliflozin does not inhibit Na+/H+ exchanger-1 or lower [Na+]i in the heart , 2020, Cardiovascular research.
[17] B. Zinman,et al. Cardiovascular outcomes and LDL-cholesterol levels in EMPA-REG OUTCOME® , 2020, Diabetes & vascular disease research.
[18] P. Ponikowski,et al. Effect of Empagliflozin on Cardiovascular and Renal Outcomes in Patients With Heart Failure by Baseline Diabetes Status , 2020, Circulation.
[19] G. Hasenfuss,et al. Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes , 2020, Journal of Molecular Medicine.
[20] J. McMurray,et al. Dapagliflozin in Patients with Chronic Kidney Disease. , 2020, The New England journal of medicine.
[21] L. Maier,et al. Empagliflozin inhibits Na+/H+ exchanger activity in human atrial cardiomyocytes , 2020, ESC heart failure.
[22] J. McMurray,et al. The dapagliflozin and prevention of adverse outcomes in chronic kidney disease (DAPA-CKD) trial: baseline characteristics , 2020, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[23] P. Ponikowski,et al. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. , 2020, The New England journal of medicine.
[24] G. Filippatos,et al. SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: a meta-analysis of the EMPEROR-Reduced and DAPA-HF trials , 2020, The Lancet.
[25] J. Januzzi,et al. Heart Failure With Reduced Ejection Fraction: A Review. , 2020, JAMA.
[26] M. Packer. Molecular, Cellular, and Clinical Evidence That Sodium‐Glucose Cotransporter 2 Inhibitors Act as Neurohormonal Antagonists When Used for the Treatment of Chronic Heart Failure , 2020, Journal of the American Heart Association.
[27] A. Mügge,et al. The molecular mechanisms associated with the physiological responses to inflammation and oxidative stress in cardiovascular diseases , 2020, Biophysical Reviews.
[28] C. Lang,et al. A randomized controlled trial of dapagliflozin on left ventricular hypertrophy in people with type two diabetes: the DAPA-LVH trial , 2020, European heart journal.
[29] Y. Yoon,et al. Different effects of SGLT2 inhibitors according to the presence and types of heart failure in type 2 diabetic patients , 2020, Cardiovascular Diabetology.
[30] Jeffrey M. Turner,et al. Empagliflozin in Heart Failure , 2020, Circulation.
[31] L. Maier,et al. Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias. , 2020, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.
[32] L. Maier,et al. Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation. , 2020, Cardiovascular research.
[33] P. Boor,et al. Empagliflozin improves left ventricular diastolic function of db/db mice. , 2020, Biochimica et biophysica acta. Molecular basis of disease.
[34] P. Donnan,et al. Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial , 2020, Diabetes Care.
[35] Akshay S. Desai,et al. Effect of Dapagliflozin on Worsening Heart Failure and Cardiovascular Death in Patients With Heart Failure With and Without Diabetes. , 2020, JAMA.
[36] Y. Aizawa,et al. The Effect of Dapagliflozin Treatment on Epicardial Adipose Tissue Volume and P-Wave Indices: An Ad-hoc Analysis of The Previous Randomized Clinical Trial , 2020, Journal of atherosclerosis and thrombosis.
[37] L. Maier,et al. CaMKII and GLUT1 in heart failure and the role of gliflozins. , 2020, Biochimica et biophysica acta. Molecular basis of disease.
[38] M. Packer. Autophagy stimulation and intracellular sodium reduction as mediators of the cardioprotective effect of sodium–glucose cotransporter 2 inhibitors , 2020, European journal of heart failure.
[39] E. Braunwald,et al. Mechanisms of Cardiorenal Effects of Sodium-Glucose Cotransporter 2 Inhibitors: JACC State-of-the-Art Review. , 2020, Journal of the American College of Cardiology.
[40] C. Cannon,et al. Sodium‐Glucose Cotransporter 2 Inhibition for the Prevention of Cardiovascular Events in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta‐Analysis , 2020, Journal of the American Heart Association.
[41] A. Avogaro,et al. Reinterpreting Cardiorenal Protection of Renal Sodium–Glucose Cotransporter 2 Inhibitors via Cellular Life History Programming , 2019, Diabetes Care.
[42] T. Maruyama,et al. Canagliflozin Improves Erythropoiesis in Diabetes Patients with Anemia of Chronic Kidney Disease , 2019, Diabetes technology & therapeutics.
[43] Deepak L. Bhatt,et al. Effect of Empagliflozin on Left Ventricular Mass in Patients with Type 2 Diabetes and Coronary Artery Disease: The EMPA-HEART CardioLink-6 Randomized Clinical Trial. , 2019, Circulation.
[44] Deepak L. Bhatt,et al. Effect of Empagliflozin on Left Ventricular Mass in Patients with Type 2 Diabetes and Coronary Artery Disease: The EMPA-HEART CardioLink-6 Randomized Clinical Trial. , 2019, Circulation.
[45] D. DeMets,et al. Efficacy and Safety of Dapagliflozin in Heart Failure With Reduced Ejection Fraction According to Age , 2019, Circulation.
[46] Lawrence A Leiter,et al. Effect of Empagliflozin on Erythropoietin Levels, Iron Stores and Red Blood Cell Morphology in Patients with Type 2 Diabetes and Coronary Artery Disease. , 2019, Circulation.
[47] M. Su,et al. Effect of Empagliflozin on Cardiac Function, Adiposity, and Diffuse Fibrosis in Patients with Type 2 Diabetes Mellitus , 2019, Scientific Reports.
[48] Akshay S. Desai,et al. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. , 2019, The New England journal of medicine.
[49] W. Paulus,et al. Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin , 2019, JACC. Basic to translational science.
[50] Liming Chen,et al. Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice. , 2019, Clinical science.
[51] M. Drazner,et al. Dapagliflozin Effects on Biomarkers, Symptoms, and Functional Status in Patients With Heart Failure With Reduced Ejection Fraction: The DEFINE-HF Trial. , 2019, Circulation.
[52] E. Briganti,et al. Effects of empagliflozin treatment on cardiac function and structure in patients with type 2 diabetes: a cardiac magnetic resonance study , 2019, Internal medicine journal.
[53] R. D. de Boer,et al. Sodium–glucose co‐transporter 2 inhibition with empagliflozin improves cardiac function in non‐diabetic rats with left ventricular dysfunction after myocardial infarction , 2019, European journal of heart failure.
[54] V. Fuster,et al. Empagliflozin Ameliorates Adverse Left Ventricular Remodeling in Nondiabetic Heart Failure by Enhancing Myocardial Energetics. , 2019, Journal of the American College of Cardiology.
[55] S. Goto,et al. Possible Mechanism of Hematocrit Elevation by Sodium Glucose Cotransporter 2 Inhibitors and Associated Beneficial Renal and Cardiovascular Effects. , 2019, Circulation.
[56] Fen Li,et al. Dapagliflozin Attenuates Cardiac Remodeling in Mice Model of Cardiac Pressure Overload , 2019, American journal of hypertension.
[57] C. Ronco,et al. Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association. , 2019, Circulation.
[58] Po-Len Liu,et al. The sodium–glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats , 2019, Cardiovascular Diabetology.
[59] H. Bøtker,et al. Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients , 2019, Circulation.
[60] C. Bailey. Uric acid and the cardio‐renal effects of SGLT2 inhibitors , 2019, Diabetes, obesity & metabolism.
[61] S. Kaul,et al. Empagliflozin reduces the risk of a broad spectrum of heart failure outcomes regardless of heart failure status at baseline , 2019, European journal of heart failure.
[62] Liming Chen,et al. SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart , 2019, Cardiovascular Diabetology.
[63] K. Connelly,et al. Empagliflozin Improves Diastolic Function in a Nondiabetic Rodent Model of Heart Failure With Preserved Ejection Fraction , 2019, JACC. Basic to translational science.
[64] Declare–Timi Investigators. Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes , 2019 .
[65] Marc P. Bonaca,et al. SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials , 2019, The Lancet.
[66] B. Zinman,et al. Empagliflozin Reduced Mortality and Hospitalization for Heart Failure Across the Spectrum of Cardiovascular Risk in the EMPA-REG OUTCOME Trial , 2018, Circulation.
[67] S. Atkin,et al. Sodium–glucose cotransporter inhibitors and oxidative stress: An update , 2018, Journal of cellular physiology.
[68] J. Gummert,et al. Empagliflozin directly improves diastolic function in human heart failure , 2018, European journal of heart failure.
[69] K. Hirata,et al. Impact of dapagliflozin on left ventricular diastolic function of patients with type 2 diabetic mellitus with chronic heart failure , 2018, Cardiovascular Diabetology.
[70] J. McMurray,et al. SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review , 2018, Diabetologia.
[71] Yong Xu,et al. SGLT2 inhibitors and risk of stroke in patients with type 2 diabetes: A systematic review and meta‐analysis , 2018, Diabetes, obesity & metabolism.
[72] L. Maier,et al. Empagliflozin reduces Ca/calmodulin‐dependent kinase II activity in isolated ventricular cardiomyocytes , 2018, ESC heart failure.
[73] Lawrence A Leiter,et al. Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes. , 2018, Metabolism: clinical and experimental.
[74] J. Gummert,et al. Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart , 2018, Cardiovascular research.
[75] Wei Wang,et al. Canagliflozin exerts anti‐inflammatory effects by inhibiting intracellular glucose metabolism and promoting autophagy in immune cells , 2018, Biochemical pharmacology.
[76] M. Packer. Do sodium‐glucose co‐transporter‐2 inhibitors prevent heart failure with a preserved ejection fraction by counterbalancing the effects of leptin? A novel hypothesis , 2018, Diabetes, obesity & metabolism.
[77] M. Mizuno,et al. Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts , 2018, Physiological reports.
[78] K. Utsunomiya,et al. Effect of canagliflozin on left ventricular diastolic function in patients with type 2 diabetes , 2018, Cardiovascular Diabetology.
[79] J. Lee,et al. The anti‐diabetic drug dapagliflozin induces vasodilation via activation of PKG and Kv channels , 2018, Life sciences.
[80] J. McMurray,et al. Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis , 2018, Diabetes, obesity & metabolism.
[81] M. von Eynatten,et al. Empagliflozin Induces Transient Diuresis Without Changing Long-Term Overall Fluid Balance in Japanese Patients With Type 2 Diabetes , 2018, Diabetes Therapy.
[82] B. Zinman,et al. Effects of empagliflozin on risk for cardiovascular death and heart failure hospitalization across the spectrum of heart failure risk in the EMPA-REG OUTCOME® trial , 2018, European heart journal.
[83] Dongli Tian,et al. Effects of sodium‐glucose co‐transporter 2 (SGLT2) inhibitors on serum uric acid level: A meta‐analysis of randomized controlled trials , 2018, Diabetes, obesity & metabolism.
[84] R. Guthrie. Canagliflozin and cardiovascular and renal events in type 2 diabetes , 2018, Postgraduate medicine.
[85] B. Zinman,et al. Empagliflozin and Clinical Outcomes in Patients With Type 2 Diabetes Mellitus, Established Cardiovascular Disease, and Chronic Kidney Disease , 2018, Circulation.
[86] Y. Aizawa,et al. The effect of dapagliflozin treatment on epicardial adipose tissue volume , 2018, Cardiovascular Diabetology.
[87] R. Coronel,et al. Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation , 2017, Diabetologia.
[88] B. Zinman,et al. How Does Empagliflozin Reduce Cardiovascular Mortality? Insights From a Mediation Analysis of the EMPA-REG OUTCOME Trial , 2017, Diabetes Care.
[89] S. Verma,et al. Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease , 2017, Heart Failure Reviews.
[90] L. Ghiadoni,et al. Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study , 2017, Cardiovascular Diabetology.
[91] D. Fitchett,et al. EMPAGLIFLOZIN (EMPA) REDUCES HEART FAILURE OUTCOMES IRRESPECTIVE OF BLOOD PRESSURE (BP), LOW DENSITY LIPOPROTEIN CHOLESTEROL (LDL-C) AND HBA1C CONTROL , 2017 .
[92] S. Zecchi-Orlandini,et al. Sodium-dependent glucose transporters (SGLT) in human ischemic heart: A new potential pharmacological target. , 2017, International journal of cardiology.
[93] J. Adamski,et al. Effect of Empagliflozin on the Metabolic Signature of Patients With Type 2 Diabetes Mellitus and Cardiovascular Disease. , 2017, Circulation.
[94] J. McMurray,et al. The Metabolodiuretic Promise of Sodium-Dependent Glucose Cotransporter 2 Inhibition: The Search for the Sweet Spot in Heart Failure. , 2017, JAMA cardiology.
[95] S. Verma,et al. Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure , 2017, JACC. Basic to translational science.
[96] L. Maier,et al. CaMKII as a target for arrhythmia suppression. , 2017, Pharmacology & therapeutics.
[97] K. Mahaffey,et al. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes , 2017, The New England journal of medicine.
[98] M. Komajda,et al. Empagliflozin Improves Left Ventricular Diastolic Dysfunction in a Genetic Model of Type 2 Diabetes , 2017, Cardiovascular Drugs and Therapy.
[99] J. Perez-polo,et al. SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor , 2017, Cardiovascular Drugs and Therapy.
[100] E. Ferrannini,et al. Renal Handling of Ketones in Response to Sodium–Glucose Cotransporter 2 Inhibition in Patients With Type 2 Diabetes , 2017, Diabetes Care.
[101] Tsung-Ming Lee,et al. Dapagliflozin, a Selective SGLT2 Inhibitor, Attenuated Cardiac Fibrosis by Regulating the Macrophage Polarization via STAT3 Signaling in Infarcted Rat Hearts , 2017, Free radical biology & medicine.
[102] V. Demarco,et al. Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodent model of diabetes , 2017, Cardiovascular Diabetology.
[103] H. Yanai,et al. A Possible Mechanism for Renoprotective Effect of Sodium-Glucose Cotransporter 2 Inhibitor: Elevation of Erythropoietin Production , 2016, Journal of clinical medicine research.
[104] A. Scheen. Effects of reducing blood pressure on cardiovascular outcomes and mortality in patients with type 2 diabetes: Focus on SGLT2 inhibitors and EMPA-REG OUTCOME. , 2016, Diabetes research and clinical practice.
[105] R. Coronel,et al. Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits , 2016, Diabetologia.
[106] M. Al-Omran,et al. Effect of Empagliflozin on Left Ventricular Mass and Diastolic Function in Individuals With Diabetes: An Important Clue to the EMPA-REG OUTCOME Trial? , 2016, Diabetes Care.
[107] R. DeFronzo,et al. Dapagliflozin Enhances Fat Oxidation and Ketone Production in Patients With Type 2 Diabetes , 2016, Diabetes Care.
[108] S. Verma,et al. Empagliflozin's Fuel Hypothesis: Not so Soon. , 2016, Cell metabolism.
[109] S. Mudaliar,et al. Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis , 2016, Diabetes Care.
[110] E. Ferrannini,et al. CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis , 2016, Diabetes Care.
[111] Christoph D. Rau,et al. Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure , 2016, Circulation.
[112] J. McMurray,et al. SGLT2 Inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms? , 2016, Diabetologia.
[113] W. Paulus,et al. Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction. , 2016, JACC. Heart failure.
[114] M. Fischereder,et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. , 2016, The New England journal of medicine.
[115] K. Margulies,et al. Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure , 2016, Circulation.
[116] B. Zinman,et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. , 2015, The New England journal of medicine.
[117] C. Cannon,et al. Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes , 2015, Diabetes, obesity & metabolism.
[118] Ichiro Tokubuchi,et al. Effects of a sodium glucose co-transporter 2 selective inhibitor, ipragliflozin, on the diurnal profile of plasma glucose in patients with type 2 diabetes: A study using continuous glucose monitoring , 2015, Journal of diabetes investigation.
[119] D. Bers,et al. Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death. , 2015, Circulation research.
[120] B. Perkins,et al. Uric acid as a biomarker and a therapeutic target in diabetes. , 2015, Canadian journal of diabetes.
[121] P. Lapuerta,et al. Development of sotagliflozin, a dual sodium-dependent glucose transporter 1/2 inhibitor , 2015, Diabetes & vascular disease research.
[122] T. Heise,et al. Effect of the sodium glucose co‐transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus , 2014, Diabetes, obesity & metabolism.
[123] M. Sasamata,et al. Effects of sodium‐glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin‐induced type 1 diabetic rats , 2014, The Journal of pharmacy and pharmacology.
[124] U. Broedl,et al. Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus , 2014, Circulation.
[125] T. Heise,et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. , 2014, The Journal of clinical investigation.
[126] M. Sasamata,et al. Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice. , 2013, European journal of pharmacology.
[127] W. Paulus,et al. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. , 2013, Journal of the American College of Cardiology.
[128] E. Kurosaki,et al. Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: preclinical and clinical data. , 2013, Pharmacology & therapeutics.
[129] D. de Zeeuw,et al. Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes , 2013, Diabetes, obesity & metabolism.
[130] W. Linke,et al. Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction. , 2013, Cardiovascular research.
[131] L. Maier,et al. The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis , 2012, Heart Failure Reviews.
[132] M. Pelleymounter,et al. Weight Loss Induced by Chronic Dapagliflozin Treatment Is Attenuated by Compensatory Hyperphagia in Diet‐Induced Obese (DIO) Rats , 2012, Obesity.
[133] R. Grempler,et al. Empagliflozin, a novel selective sodium glucose cotransporter‐2 (SGLT‐2) inhibitor: characterisation and comparison with other SGLT‐2 inhibitors , 2012, Diabetes, obesity & metabolism.
[134] L. Maier,et al. Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδC can be reversed by inhibition of late Na+ current , 2010, Basic Research in Cardiology.
[135] J. Gummert,et al. Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium , 2010, Circulation research.
[136] H. Mächler,et al. Glucose-transporter-mediated positive inotropic effects in human myocardium of diabetic and nondiabetic patients. , 2010, Metabolism: clinical and experimental.
[137] B. Rovin,et al. Uric acid and cardiovascular risk. , 2009, The New England journal of medicine.
[138] Duk-Hee Kang,et al. Uric acid and cardiovascular risk. , 2008, The New England journal of medicine.
[139] G. Tenderich,et al. Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation. , 2008, Journal of molecular and cellular cardiology.
[140] K. Maiese,et al. Erythropoietin and oxidative stress. , 2008, Current neurovascular research.
[141] D. Lau,et al. Adipokines: molecular links between obesity and atheroslcerosis. , 2005, American journal of physiology. Heart and circulatory physiology.
[142] R. Coronel,et al. Increased Na+/H+-exchange activity is the cause of increased [Na+]i and underlies disturbed calcium handling in the rabbit pressure and volume overload heart failure model. , 2003, Cardiovascular research.
[143] D. Bers. Cardiac excitation–contraction coupling , 2002, Nature.
[144] D. J. Veldhuisen,et al. Sodium-glucose cotransporter 2 inhibition with empagliflozin improves cardiac function in non-diabetic rats with left ventricular dysfunction after myocardial infarction , 2019 .
[145] C. Maack,et al. Cardiac effects of SGLT2 inhibitors: the sodium hypothesis , 2018, Cardiovascular research.
[146] J. J. Smith,et al. Heart failure etiology affects peripheral vascular endothelial function after cardiac transplantation. , 2001, Journal of the American College of Cardiology.