Precision extruding deposition and characterization of cellular poly‐ε‐caprolactone tissue scaffolds

Successes in scaffold guided tissue engineering require scaffolds to have specific macroscopic geometries and internal architectures to provide the needed biological and biophysical functions. Freeform fabrication provides an effective process tool to manufacture many advanced scaffolds with designed properties. This paper reports our recent study on using a novel precision extruding deposition (PED) process technique to directly fabricate cellular poly‐e_rm;‐caprolactone (PCL) scaffolds. Scaffolds with a controlled pore size of 250 μm and designed structural orientations were fabricated.

[1]  P Rüegsegger,et al.  Tissue stresses and strain in trabeculae of a canine proximal femur can be quantified from computer reconstructions. , 1999, Journal of biomechanics.

[2]  P Rüegsegger,et al.  Micro-tomographic imaging for the nondestructive evaluation of trabecular bone architecture. , 1997, Studies in health technology and informatics.

[3]  Robert E Guldberg,et al.  Microarchitectural and mechanical characterization of oriented porous polymer scaffolds. , 2003, Biomaterials.

[4]  Robert Weiss,et al.  Morphological Control in Multiphase Polymer Mixtures , 1996 .

[5]  P H Krebsbach,et al.  Indirect solid free form fabrication of local and global porous, biomimetic and composite 3D polymer-ceramic scaffolds. , 2003, Biomaterials.

[6]  D. Hutmacher,et al.  Scaffolds in tissue engineering bone and cartilage. , 2000, Biomaterials.

[7]  Emanuel M. Sachs,et al.  Solid free-form fabrication of drug delivery devices , 1996 .

[8]  I. Zein,et al.  Fused deposition modeling of novel scaffold architectures for tissue engineering applications. , 2002, Biomaterials.

[9]  Wei Sun,et al.  Computer‐aided tissue engineering: overview, scope and challenges , 2004, Biotechnology and applied biochemistry.

[10]  K. Leong,et al.  The design of scaffolds for use in tissue engineering. Part II. Rapid prototyping techniques. , 2002, Tissue engineering.

[11]  Wei Sun,et al.  Computer‐aided tissue engineering: application to biomimetic modelling and design of tissue scaffolds , 2004, Biotechnology and applied biochemistry.

[12]  Yongnian Yan,et al.  Fabrication of porous poly(l-lactic acid) scaffolds for bone tissue engineering via precise extrusion , 2001 .

[13]  P Rüegsegger,et al.  3D Micro-Tomographic imaging and Quantitative Morphometry for the Nondestructive Evaluation of Porous Biomaterials , 1996 .

[14]  Wei Sun,et al.  Computer aided tissue engineering part II: application to biomimetic modeling and ARTICLE IN PRESS J , 2004 .

[15]  Wei Sun,et al.  Recent development on computer aided tissue engineering - a review , 2002, Comput. Methods Programs Biomed..

[16]  Anna Bellini,et al.  Fused deposition of ceramics: A comprehensive experimental, analytical and computational study of material behavior, fabrication process and equipment design , 2002 .

[17]  S. Hollister,et al.  Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints. , 2002, Biomaterials.

[18]  A Ahluwalia,et al.  Microsyringe-based deposition of two-dimensional and three-dimensional polymer scaffolds with a well-defined geometry for application to tissue engineering. , 2002, Tissue engineering.