A 3-D differential coil design for localized magnetic stimulation

A novel three-dimensional (3-D) differential coil has been designed for improving the localization of magnetic stimulation. This new coil design consists of a butterfly coil with two additional wing units and an extra bottom unit, both perpendicular to the plane of the butterfly coil. The wing units produce opposite fields to restrict the spread of induced fields while the bottom unit enhances the induced fields at the excitation site. The peak induced field generated by this new design is located at the center of the coil, providing an easy identification of the excitation site. The field localization of the new coil Is comparable with that of much smaller coils but with an inductance compatible to current magnetic stimulators. Numerical computations based on the principles of electromagnetic induction and using a human nerve model were performed to analyze the induced fields and the stimulation thresholds of new coil designs. The localization of the coil design was assessed by a half power region (HPB), within which the magnitude of the normalized induced field is greater than 1//spl radic/2. The HPR for a 3-D differential coil built is improved (decreased) by a factor of three compared with a standard butterfly coil. Induced fields by this new coil were measured and in agreement with theoretical calculations.

[1]  M. Rushworth,et al.  A primer of magnetic stimulation as a tool for neuropsychology. , 1999, Neuropsychologia.

[2]  Shoogo Ueno,et al.  Localized stimulation of the human brain and spinal cord by a pair of opposing pulsed magnetic fields , 1990 .

[3]  J Moxham,et al.  Functional magnetic stimulation of the abdominal muscles in humans. , 1999, American journal of respiratory and critical care medicine.

[4]  J Moxham,et al.  Simulation of cough in man by magnetic stimulation of the thoracic nerve roots. , 1997, American journal of respiratory and critical care medicine.

[5]  M.A. Stuchly,et al.  Neural stimulation with magnetic fields: analysis of induced electric fields , 1992, IEEE Transactions on Biomedical Engineering.

[6]  M A Stuchly,et al.  Design and fabrication of well confined uniform magnetic field exposure systems. , 1994, Bioelectromagnetics.

[7]  D. Durand,et al.  Effects of induced electric fields on finite neuronal structures: a simulation study , 1993, IEEE Transactions on Biomedical Engineering.

[8]  A. Barker,et al.  NON-INVASIVE MAGNETIC STIMULATION OF HUMAN MOTOR CORTEX , 1985, The Lancet.

[9]  D. Popović,et al.  A novel electric design for electromagnetic stimulation-the Slinky coil , 1995, IEEE Transactions on Biomedical Engineering.

[10]  I Perkash,et al.  Micturition by functional magnetic stimulation. , 1997, The journal of spinal cord medicine.

[11]  O. Witte,et al.  Epileptic seizures triggered directly by focal transcranial magnetic stimulation. , 1995, Electroencephalography and clinical neurophysiology.

[12]  D. Cohen,et al.  Developing a more focal magnetic stimulator. Part II: Fabricating coils and measuring induced current distributions. , 1991, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[13]  Z. Nahas,et al.  rTMS studies of mood and emotion. , 1999, Electroencephalography and clinical neurophysiology. Supplement.

[14]  V. Amassian,et al.  Matching focal and non-focal magnetic coil stimulation to properties of human nervous system: mapping motor unit fields in motor cortex contrasted with altering sequential digit movements by premotor-SMA stimulation. , 1991, Electroencephalography and clinical neurophysiology. Supplement.

[15]  Dominique M. Durand,et al.  Prediction of neural excitation during magnetic stimulation using passive cable models , 2000, IEEE Trans. Biomed. Eng..

[16]  K. Harada,et al.  Localized stimulation of neural tissues in the brain by means of a paired configuration of time-varying magnetic fields , 1988 .

[17]  S. Bandinelli,et al.  Effects of coil design on delivery of focal magnetic stimulation. Technical considerations. , 1990, Electroencephalography and clinical neurophysiology.

[18]  J Cadwell,et al.  Optimizing magnetic stimulator design. , 1991, Electroencephalography and clinical neurophysiology. Supplement.

[19]  M. Stuchly,et al.  Modeling of magnetic field stimulation of bent neurons , 1994, IEEE Transactions on Biomedical Engineering.

[20]  Dominique M. Durand,et al.  MODELING OF MAMMALIAN MYELINATED NERVE FOR FUNCTIONAL NEUROMUSCULAR STIMULATION. , 1987 .

[21]  M. Hallett,et al.  Noninvasive mapping of muscle representations in human motor cortex. , 1992, Electroencephalography and clinical neurophysiology.

[22]  J Cadwell,et al.  In vitro evaluation of a 4-leaf coil design for magnetic stimulation of peripheral nerve. , 1994, Electroencephalography and clinical neurophysiology.

[23]  H. Tokimura,et al.  Identification of the cerebral motor cortex by focal magnetic stimulation: clinical application to neurosurgical patients. , 1994, Stereotactic and functional neurosurgery.

[24]  B N Cuffin,et al.  Developing a more focal magnetic stimulator. Part I: Some basic principles. , 1991, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[25]  P. Sand,et al.  Extracorporeal magnetic innervation therapy for stress urinary incontinence. , 1999, Urology.

[26]  A. S. Ferguson,et al.  Effect of surface boundary on neuronal magnetic stimulation , 1992, IEEE Transactions on Biomedical Engineering.

[27]  J. M. Ritchie,et al.  A quantitative description of membrane currents in rabbit myelinated nerve. , 1979, The Journal of physiology.

[28]  E. Wassermann Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. , 1998, Electroencephalography and clinical neurophysiology.

[29]  V. Amassian,et al.  Magnetic coil stimulation of straight and bent amphibian and mammalian peripheral nerve in vitro: locus of excitation. , 1993, The Journal of physiology.

[30]  S. Ramo,et al.  Fields and Waves in Communication Electronics , 1966 .

[31]  V. Amassian,et al.  Modelling magnetic coil excitation of human cerebral cortex with a peripheral nerve immersed in a brain-shaped volume conductor: the significance of fiber bending in excitation. , 1992, Electroencephalography and clinical neurophysiology.

[32]  V E Amassian,et al.  Cerebello-frontal cortical projections in humans studied with the magnetic coil. , 1992, Electroencephalography and clinical neurophysiology.

[33]  Cortical representation of proximal and distal arm muscles as assessed by focal transcranial magnetic stimulation. , 1998, Electromyography and clinical neurophysiology.