Study of tablet-coating parameters for a pan coater through video imaging and Monte Carlo simulation

Abstract The movement of tablets in a pan coater and the exposure of different surfaces of tablets for deposition of coatings by spray-coating have been studied by video imaging and Monte Carlo simulation techniques. A representative variety of tablets of different shapes and sizes were used at different pan loads and at various pan speeds. A single “tracer” tablet was used to track the motion of tablets and coating variables such as circulation time, surface time, projected surface area and surface velocity of a tablet were determined from the video imaging experiments. The coating uniformity is described in terms of the coating variation from tablet to tablet CV(tt) and a new parameter CV(st) the coating variation on a single tablet. The effect of shape of tablets on coating uniformity was analyzed by introducing a “sphericity” of tablet ( φ s ) into the CV models. The methodology, new models and the analysis developed here incorporating the additional parameters will help users to optimize the coating process in pan-coating operations.

[1]  Richard Turton,et al.  Movement of different-shaped particles in a pan-coating device using novel video-imaging techniques , 2005, AAPS PharmSciTech.

[2]  Jagdish Singh,et al.  Passive and iontophoretic transport enhancement of insulin through porcine epidermis by depilatories: Permeability and fourier transform infrared spectroscopy studies , 2008, AAPS PharmSciTech.

[3]  A. Yu,et al.  Microdynamic analysis of particle flow in a horizontal rotating drum , 2003 .

[4]  KuZilati KuShaari,et al.  Monte Carlo simulations to determine coating uniformity in a Wurster fluidized bed coating process , 2006 .

[5]  Richard Turton,et al.  Simulation of particle movement in a pan coating device using discrete element modeling and its comparison with video-imaging experiments , 2006 .

[6]  B Buisson,et al.  A model of surface renewal with application to the coating of pharmaceutical tablets in rotary drums , 2003 .

[7]  Douglas W. Fuerstenau,et al.  Simulation of diffusional mixing of particulate solids by Monte Carlo techniques , 1967 .

[8]  Richard Turton,et al.  Modeling weight variability in a pan coating process using Monte Carlo simulations , 2006, AAPS PharmSciTech.

[9]  Richard Turton,et al.  Contact detection algorithms for DEM simulations of tablet-shaped particles , 2006 .

[10]  M. Rubinovitch,et al.  Characterization and analysis of continuous recycle systems , 1979 .

[11]  Richard Turton,et al.  Challenges in the modeling and prediction of coating of pharmaceutical dosage forms , 2008 .

[12]  Peter Kleinebudde,et al.  Prediction of tablet velocity in pan coaters for scale-up , 2007 .

[13]  G. Macleod,et al.  Mixing efficiency in side-vented coating equipment , 2003, AAPS PharmSciTech.

[14]  Richard Turton,et al.  In situ, near real-time acquisition of particle motion in rotating pan coating equipment using imaging techniques , 2004 .