Catalytic mechanism of DNA topoisomerase IB.

[1]  S. Shuman,et al.  DNA strand transfer catalyzed by vaccinia topoisomerase: peroxidolysis and hydroxylaminolysis of the covalent protein-DNA intermediate. , 2000, Biochemistry.

[2]  W. Stec,et al.  Stereochemical outcome and kinetic effects of Rp- and Sp-phosphorothioate substitutions at the cleavage site of vaccinia type I DNA topoisomerase. , 2000, Biochemistry.

[3]  J. Denu,et al.  Mechanistic Basis for Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase 3 by Extracellular Signal-regulated Kinase* , 2000, The Journal of Biological Chemistry.

[4]  A. Burgin,et al.  Melanoplus sanguinipes entomopoxvirus DNA topoisomerase: site-specific DNA transesterification and effects of 5'-bridging phosphorothiolates. , 1999, Virology.

[5]  F. Guo,et al.  Asymmetric DNA bending in the Cre-loxP site-specific recombination synapse. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Y. Cao,et al.  A newly identified, essential catalytic residue in a critical secondary structure element in the integrase family of site-specific recombinases is conserved in a similar element in eucaryotic type IB topoisomerases. , 1999, Journal of molecular biology.

[7]  S. Keyse,et al.  Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation , 1999, Nature Structural Biology.

[8]  S. Shuman.  Vaccinia virus DNA topoisomerase: a model eukaryotic type IB enzyme. , 1998, Biochimica et biophysica acta.

[9]  F. Guo,et al.  Structure of the Holliday junction intermediate in Cre–loxP site‐specific recombination , 1998, The EMBO journal.

[10]  F. Boege,et al.  Camptothecins inhibit the utilization of hydrogen peroxide in the ligation step of topoisomerase I catalysis. , 1998, Biochemistry.

[11]  Chonghui Cheng,et al.  Conservation of Structure and Mechanism between Eukaryotic Topoisomerase I and Site-Specific Recombinases , 1998, Cell.

[12]  J. Champoux,et al.  Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. , 1998, Science.

[13]  K. Guan,et al.  Altering the Nucleophile Specificity of a Protein-tyrosine Phosphatase-catalyzed Reaction , 1998, The Journal of Biological Chemistry.

[14]  W G Hol,et al.  A model for the mechanism of human topoisomerase I. , 1998, Science.

[15]  F. Guo,et al.  Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse , 1997, Nature.

[16]  L. Bird,et al.  Crystal structure of the site‐specific recombinase, XerD , 1997, The EMBO journal.

[17]  S. Shuman,et al.  Mechanism of DNA transesterification by vaccinia topoisomerase: catalytic contributions of essential residues Arg-130, Gly-132, Tyr-136 and Lys-167. , 1997, Nucleic acids research.

[18]  S. Shuman,et al.  DNA strand transfer reactions catalyzed by vaccinia topoisomerase: hydrolysis and glycerololysis of the covalent protein-DNA intermediate. , 1997, Nucleic acids research.

[19]  F. Dyda,et al.  Molecular Organization in Site-Specific Recombination: The Catalytic Domain of Bacteriophage HP1 Integrase at 2.7 Å Resolution , 1997, Cell.

[20]  T. Ellenberger,et al.  Flexibility in DNA Recombination: Structure of the Lambda Integrase Catalytic Core , 1997, Science.

[21]  Chonghui Cheng,et al.  Mutational Analysis of 39 Residues of Vaccinia DNA Topoisomerase Identifies Lys-220, Arg-223, and Asn-228 as Important for Covalent Catalysis* , 1997, The Journal of Biological Chemistry.

[22]  S. Shuman,et al.  Histidine 265 Is Important for Covalent Catalysis by Vaccinia Topoisomerase and Is Conserved in All Eukaryotic Type I Enzymes* , 1997, The Journal of Biological Chemistry.

[23]  S. Shuman,et al.  Mutations within a conserved region of vaccinia topoisomerase affect the DNA cleavage-religation equilibrium. , 1996, Journal of molecular biology.

[24]  K. Eckart,et al.  Synthesis and Properties of Diuridine Phosphate Analogues Containing Thio and Amino Modifications. , 1996, The Journal of organic chemistry.

[25]  S. Shuman,et al.  Identification of contacts between topoisomerase I and its target DNA by site‐specific photocrosslinking. , 1996, The EMBO journal.

[26]  J. Svejstrup,et al.  Purification and characterization of human topoisomerase I mutants. , 1996, European journal of biochemistry.

[27]  H. Nash,et al.  A novel suicide substrate for DNA topoisomerases and site-specific recombinases. , 1995, Nucleic acids research.

[28]  D. Barford,et al.  Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. , 1995, Science.

[29]  S. Shuman,et al.  Proteolytic footprinting of vaccinia topoisomerase bound to DNA , 1995, The Journal of Biological Chemistry.

[30]  A. Mildvan,et al.  Vaccinia DNA topoisomerase I: kinetic evidence for general acid-base catalysis and a conformational step. , 1994, Biochemistry.

[31]  S. Shuman,et al.  Vaccinia topoisomerase binds circumferentially to DNA. , 1994, The Journal of biological chemistry.

[32]  E. Fauman,et al.  Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate , 1994, Nature.

[33]  B. Knudsen,et al.  The covalent eukaryotic topoisomerase I-DNA intermediate catalyzes pH-dependent hydrolysis and alcoholysis. , 1994, The Journal of biological chemistry.

[34]  S. Shuman.  DNA strand transfer reactions catalyzed by vaccinia topoisomerase I. , 1992, The Journal of biological chemistry.

[35]  K. Mizuuchi,et al.  Inversion of the phosphate chirality at the target site of Mu DNA strand transfer: Evidence for a one-step transesterification mechanism , 1991, Cell.