Paired kidney donations to expand the living donor pool: the Western Australian experience

Falling numbers of deceased organ donors and longer kidney transplant waiting lists have increased the emphasis on live kidney donation to meet demand for kidney transplantation. Several new strategies have been introduced to expand live donation beyond the classic direct donation. These include: altruistic donation; paired kidney exchange (PKE); and altruistic donor chains programs. Using incompatible donor–recipient pairs and altruistic donors, the Western Australian PKE program achieved nine successful kidney transplantations between October 2007 and November 2008. If PKE were performed routinely in Australia, the rate of kidney transplants could increase by 7%–10%.

[1]  A J Matas,et al.  Nondirected donation of kidneys from living donors. , 2000, The New England journal of medicine.

[2]  H. Genberg,et al.  ABO Incompatible Kidney Transplantations Without Splenectomy, Using Antigen‐Specific Immunoadsorption and Rituximab , 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[3]  W. Weimar,et al.  Long-term consequences of kidney donation. , 2009, The New England journal of medicine.

[4]  G. Oniscu,et al.  Impact of cadaveric renal transplantation on survival in patients listed for transplantation. , 2005, Journal of the American Society of Nephrology : JASN.

[5]  F. Delmonico,et al.  Exchanging kidneys--advances in living-donor transplantation. , 2004, The New England journal of medicine.

[6]  F. Delmonico,et al.  The Development of a Successful Multiregional Kidney Paired Donation Program , 2008, Transplantation.

[7]  F T Rapaport,et al.  The case for a living emotionally related international kidney donor exchange registry. , 1986, Transplantation proceedings.

[8]  D. Segev,et al.  Domino paired kidney donation: a strategy to make best use of live non-directed donation , 2006, The Lancet.

[9]  Rapaport Ft,et al.  The case for a living emotionally related international kidney donor exchange registry. , 1986 .

[10]  L. Kavoussi,et al.  Clinical results from transplanting incompatible live kidney donor/recipient pairs using kidney paired donation. , 2005, JAMA.

[11]  R. Raper,et al.  The shortage of kidneys for transplantation in Australia , 2005, The Medical journal of Australia.

[12]  Frans H J Claas,et al.  Hurdles, Barriers, and Successes of a National Living Donor Kidney Exchange Program , 2008, Transplantation.