Journal Pre-proof Red blood cells protein profile is modified in breast cancer patients

Metastasis is the primary cause of death for most breast cancer patients who succumb to the disease. During the haematogenous dissemination, circulating tumor cells interact with different blood components. Thus, there are micro-environmental and systemic processes contributing to cancer regulation. We have recently published that Red Blood Cells (RBCs) that accompany circulating tumor cells have prognostic potential for metastatic breast cancer patients. Seemingly, RBCs are acquiring modifications in their proteomic composition that probably represents the systemic cancer disease, conditioned by the tumor microenvironment.

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