Development and application of an unconstrained technique for patient positioning in fixed radiation beams.

A flexible technique for positioning patients in fixed orientation radiation fields such as those used in neutron capture therapy (NCT) has been developed. The positioning technique employs reference points marked on the patient in combination with a 3D digitizer to determine the beam entry point and a template fitted to the patient's head is used to determine the proper beam orientation. A coordinate transformation between the CT image data and reference points on the patient determined by a least squares algorithm based on singular value decomposition is used to map the beam entry point from the planning system onto the patient. The technique was validated in a phantom study where the mean error in entry point placement was 1.3 mm. Five glioblastoma multiforme patients have been treated with NCT using this positioning technique.