Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2.
暂无分享,去创建一个
M. Humar | C. Schwer | S. Rospert | E. Fitzke | H. Bürkle | P. Stoll | R. Schmidt | N. Schallner
[1] M. Zou,et al. AMP-activated protein kinase, stress responses and cardiovascular diseases. , 2012, Clinical science.
[2] D. Sabatini,et al. A unifying model for mTORC1-mediated regulation of mRNA translation , 2012, Nature.
[3] E. Denamur,et al. Differential antibacterial activity against Pseudomonas aeruginosa by carbon monoxide-releasing molecules. , 2012, Antioxidants & redox signaling.
[4] T. Loop,et al. p38β-regulated induction of the heat shock response by carbon monoxide releasing molecule CORM-2 mediates cytoprotection in lung cells in vitro. , 2011, European journal of pharmacology.
[5] S. Gamblin,et al. AMP-activated protein kinase: nature's energy sensor. , 2011, Nature chemical biology.
[6] M. Teixeira,et al. Reactive Oxygen Species Mediate Bactericidal Killing Elicited by Carbon Monoxide-releasing Molecules* , 2011, The Journal of Biological Chemistry.
[7] G. Kaul,et al. Eukaryotic elongation factor‐2 (eEF2): its regulation and peptide chain elongation , 2011, Cell biochemistry and function.
[8] M. Mayer,et al. The Chaperone Network Connected to Human Ribosome-Associated Complex , 2011, Molecular and Cellular Biology.
[9] L. Otterbein,et al. The therapeutic potential of carbon monoxide , 2010, Nature Reviews Drug Discovery.
[10] S. Kimball,et al. Control of Translation Initiation through Integration of Signals Generated by Hormones, Nutrients, and Exercise* , 2010, The Journal of Biological Chemistry.
[11] N. Sonenberg,et al. mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs , 2010, Science.
[12] M. Humar,et al. Carbon Monoxide Releasing Molecule-2 Inhibits Pancreatic Stellate Cell Proliferation by Activating p38 Mitogen-Activated Protein Kinase/Heme Oxygenase-1 Signaling , 2010, Molecular Pharmacology.
[13] T. Yoshikawa,et al. Carbon Monoxide Liberated from CO-Releasing Molecule (CORM-2) Attenuates Ischemia/Reperfusion (I/R)-Induced Inflammation in the Small Intestine , 2010, Inflammation.
[14] E. Denamur,et al. A carbon monoxide‐releasing molecule (CORM‐3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[15] M. Humar,et al. Heme Oxygenase-1 Inhibits the Proliferation of Pancreatic Stellate Cells by Repression of the Extracellular Signal-Regulated Kinase1/2 Pathway , 2008, Journal of Pharmacology and Experimental Therapeutics.
[16] S. Gordon,et al. AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions. , 2008, Journal of applied physiology.
[17] R. Bülow,et al. Antifibrogenic effects of histone deacetylase inhibitors on pancreatic stellate cells. , 2007, Biochemical pharmacology.
[18] J. Balschi,et al. Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. , 2007, American journal of physiology. Heart and circulatory physiology.
[19] J. Pouysségur,et al. The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition , 2007, Oncogene.
[20] T. Billiar,et al. Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[21] M. Alcaraz,et al. The carbon monoxide‐releasing molecule CORM‐2 inhibits the inflammatory response induced by cytokines in Caco‐2 cells , 2007, British journal of pharmacology.
[22] M. Omary,et al. The pancreatic stellate cell: a star on the rise in pancreatic diseases. , 2007, The Journal of clinical investigation.
[23] Jason M. Lynam,et al. Bioactive Properties of Iron-Containing Carbon Monoxide-Releasing Molecules , 2006, Journal of Pharmacology and Experimental Therapeutics.
[24] Y. Surh,et al. Carbon monoxide protects PC12 cells from peroxynitrite-induced apoptotic death by preventing the depolarization of mitochondrial transmembrane potential. , 2006, Biochemical and biophysical research communications.
[25] Jawed Alam,et al. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. , 2006, Physiological reviews.
[26] C. Proud. Regulation of protein synthesis by insulin. , 2006, Biochemical Society transactions.
[27] M. Rennie. Why muscle stops building when it's working , 2005, The Journal of physiology.
[28] R. Motterlini,et al. Mitochondrial Respiratory Chain and NAD(P)H Oxidase Are Targets for the Antiproliferative Effect of Carbon Monoxide in Human Airway Smooth Muscle* , 2005, Journal of Biological Chemistry.
[29] R. Foresti,et al. Carbon monoxide‐releasing molecules (CO‐RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages , 2005, British journal of pharmacology.
[30] M. Apte,et al. Mechanisms of Pancreatic Fibrosis , 2005, Digestive Diseases.
[31] J S Wilson,et al. Desmoplastic Reaction in Pancreatic Cancer: Role of Pancreatic Stellate Cells , 2004, Pancreas.
[32] J. Raymond,et al. Mitogen-induced Rapid Phosphorylation of Serine 795 of the Retinoblastoma Gene Product in Vascular Smooth Muscle Cells Involves ERK Activation* , 2004, Journal of Biological Chemistry.
[33] Christopher G. Proud,et al. A Novel mTOR-Regulated Phosphorylation Site in Elongation Factor 2 Kinase Modulates the Activity of the Kinase and Its Binding to Calmodulin , 2004, Molecular and Cellular Biology.
[34] P. Alm,et al. Carbon monoxide stimulates insulin release and propagates Ca2+ signals between pancreatic beta-cells. , 2003, American journal of physiology. Endocrinology and metabolism.
[35] Ò. Miró,et al. Carbon monoxide specifically inhibits cytochrome c oxidase of human mitochondrial respiratory chain. , 2003, Pharmacology & toxicology.
[36] N. Bodyak,et al. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury , 2003, Nature Medicine.
[37] C. Proud,et al. Regulation of peptide-chain elongation in mammalian cells. , 2002, European journal of biochemistry.
[38] N. Matsumura,et al. Establishment of a novel collagenase perfusion method to isolate rat pancreatic stellate cells and investigation of their gene expression of TGF-beta1, type I collagen, and CTGF in primary culture or freshly isolated cells. , 2002, Acta medica Okayama.
[39] Rita Kumar,et al. Molecular Pathways of Protein Synthesis Inhibition during Brain Reperfusion: Implications for Neuronal Survival or Death , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[40] J. Nevins,et al. The E2F1–3 transcription factors are essential for cellular proliferation , 2001, Nature.
[41] Y. Surh,et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. , 2001, Mutation research.
[42] C. Proud,et al. Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase , 2001, The EMBO journal.
[43] C. Proud,et al. Interplay between insulin and nutrients in the regulation of translation factors. , 2001, Biochemical Society transactions.
[44] G. Thomas,et al. Ribosomal S6 kinase signaling and the control of translation. , 1999, Experimental cell research.
[45] R. Rhoads. Signal Transduction Pathways That Regulate Eukaryotic Protein Synthesis* , 1999, The Journal of Biological Chemistry.
[46] S. Gammeltoft,et al. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction , 1999, Molecular and Cellular Endocrinology.
[47] M. Lanotte,et al. cAMP inhibits translation by inducing Ca2+/calmodulin‐independent elongation factor 2 kinase activity in IPC‐81 cells , 1999, FEBS letters.
[48] R. Denton,et al. Regulation of protein-synthesis elongation-factor-2 kinase by cAMP in adipocytes. , 1998, The Biochemical journal.
[49] R. Schmid,et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. , 1998, Gastroenterology.
[50] M. Korsten,et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture , 1998, Gut.
[51] Robert A. Weinberg,et al. Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes , 1998, Molecular and Cellular Biology.
[52] C. Proud,et al. Molecular mechanisms for the control of translation by insulin. , 1997, The Biochemical journal.
[53] Christine C. Hudson,et al. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. , 1997, Science.
[54] G. Thomas,et al. The modular phosphorylation and activation of p70s6k , 1997, FEBS letters.
[55] M Wiedmann,et al. Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[56] Christopher G. Proud,et al. Cloning and Expression of cDNA Encoding Protein Synthesis Elongation Factor-2 Kinase* , 1996, The Journal of Biological Chemistry.
[57] A. Gingras,et al. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function , 1994, Nature.
[58] C. Proud. Peptide-chain elongation in eukaryotes , 1994, Molecular Biology Reports.
[59] C. Turck,et al. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit , 1993, Nature.
[60] S. Martin,et al. Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts. , 1993, Immunology letters.
[61] James M. Roberts,et al. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle , 1992 .
[62] T. Cotter,et al. Induction of apoptosis (programmed cell death) in tumour cell lines by widely diverging stimuli. , 1990, Biochemical Society transactions.
[63] A. Ryazanov,et al. Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation , 1988, Nature.
[64] A. Nairn,et al. Identification of calmodulin-dependent protein kinase III and its major Mr 100,000 substrate in mammalian tissues. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[65] H. Marver,et al. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. , 1968, Proceedings of the National Academy of Sciences of the United States of America.
[66] R. Potter,et al. Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic mice. , 2008, American journal of physiology. Gastrointestinal and liver physiology.
[67] C. Green,et al. A carbon monoxide-releasing molecule (CORM-3) attenuates lipopolysaccharide- and interferon-gamma-induced inflammation in microglia. , 2006, Pharmacological reports : PR.
[68] M. López-Lastra,et al. Protein synthesis in eukaryotes: the growing biological relevance of cap-independent translation initiation. , 2005, Biological research.
[69] P. Kleihues,et al. Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus , 2004, Acta Neuropathologica.
[70] C. Proud,et al. Role of mTOR signalling in the control of translation initiation and elongation by nutrients. , 2004, Current topics in microbiology and immunology.
[71] A. Gingras,et al. Control of translation by the target of rapamycin proteins. , 2001, Progress in molecular and subcellular biology.
[72] S. Kimball. Eukaryotic initiation factor eIF2. , 1999, The international journal of biochemistry & cell biology.
[73] S. Kimball,et al. Effect of amino acid deprivation on initiation of protein synthesis in rat hepatocytes. , 1989, The American journal of physiology.