EXPERIMENTAL STUDIES ON THE DEVELOPMENT OF THE THYMUS

Experiments utilizing chromosome marker and histological techniques in combination with parabiosis and transplanatation procedures have demonstrated an inflow of blood-home stem cells into the chick embryo thymic rudiment. There is close similarity between the histological picture in the chick and in the mouse thymic rudiment, and it is proposed that a similar developmental process takes place in both. It may be concluded that the epithelial component of the thymic rudiment, rather than producing lymphoid cells itself, furnishes an inductive environment for the proliferation and differentiation of stem cells derived extrinsically.

[1]  A. Magro,et al.  In vitro studies of histamine release from rabbit leukocytes by divalent haptens. , 1974, Journal of immunology.

[2]  K. Ishizaka,et al.  Mechanisms of passive sensitization. 3. Number of IgE molecules and their receptor sites on human basophil granulocytes. , 1973, Journal of immunology.

[3]  H. Metzger,et al.  SURFACE IgE ON HUMAN BASOPHILS DURING HISTAMINE RELEASE , 1973, The Journal of experimental medicine.

[4]  M. Halonen,et al.  Ontogeny of the release and reactivity to the mediators of IgE-induced acute allergic reactions in the rabbit: the homologous PCA reaction. , 1973, Journal of immunology.

[5]  H. Mossmann,et al.  Bacteriophage Conjugates: The Effect of Coupling Reaction and Specific Antibodies on the Kinetics of Inactivation and Reactivation , 1973, Zeitschrift fur Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie.

[6]  S. Alkan,et al.  ANTIGEN RECOGNITION AND THE IMMUNE RESPONSE , 1972, The Journal of experimental medicine.

[7]  P. Montgomery,et al.  Homogeneous Antibody Elicited with Dinitrophenyl-Gramicidin-S , 1972 .

[8]  S. Raffel,et al.  Univalent arsanilic acid derivatives as elicitors of passive cutaneous anaphylaxis. , 1971, Journal of immunology.

[9]  M. Taniguchi,et al.  Regulation of homocytotropic antibody formation in the rat. IV. Effects of various immunosuppressive drugs. , 1971, Journal of immunology.

[10]  N. Vaz,et al.  Persistent formation of reagins in mice injected with low doses of ovalbuminl. , 1971, Immunology.

[11]  T. Schmid,et al.  Detection of homocytotropic antibody associated with a unique immunoglobulin class in the bovine species , 1971, European journal of immunology.

[12]  E. Rüde,et al.  Synthesis of a radioiodine‐labeled 2,4‐dinitrophenyl‐hapten and its use for binding assays , 1971, European journal of immunology.

[13]  G. Johansson,et al.  Structure and function of human immunoglobulin E. , 1971, Advances in immunology.

[14]  F. Franek,et al.  The antibody response of pigs to dinitrophenylated bovine IgG administered with a novel type of adjuvant , 1971, European journal of immunology.

[15]  N. Vaz,et al.  Effect of combinations of inbred strain, antigen, and antigen dose on immune responsiveness and reagin production in the mouse. A potential mouse model for immune aspects of human atopic allergy. , 1970, International archives of allergy and applied immunology.

[16]  R. Tigelaar,et al.  Passive cutaneous anaphylactic and Schultz-Dale reactions elicited in guinea pigs by chemically univalent dinitrophenyl-derivatives of bacitracin A and papain. , 1969, Journal of immunology.

[17]  K. Ishizaka,et al.  Immune mechanisms of reversed type reaginic hypersensitivity. , 1969, Journal of immunology.

[18]  C. Schneider,et al.  Molecular and Stereochemical Properties Required of Antigens for the Elicitation of Allergic Reactions , 1969 .

[19]  B. Kickhöfen,et al.  Molecular classes and properties of antibodies in cattle serum and colostrum synthesized during the primary and secondary response to protein antigens. , 1968, European journal of biochemistry.

[20]  B. Levine,et al.  The nature of the antigen-antibody complexes initiating the specific wheal-and-flare reaction in sensitized man. , 1968, The Journal of clinical investigation.

[21]  V. Jones,et al.  Reaginic antibodies and immunity to Nippostrongylus brasiliensis in the rat , 1967, Parasitology.

[22]  Kung-Tsung Wang,et al.  Polyamide Layer Chromatography of DNP Amino-acids , 1965, Nature.

[23]  J. Hurlimann,et al.  Relationship between affinity of anti-dinitrophenyl antibodies and their biologic activities. , 1965, Journal of immunology.

[24]  Z. Óváry.  PCA REACTION AND ITS ELICITATION BY SPECIFIC IMMUNOGLOBULIN SPECIES AND FRAGMENTS. , 1965, Federation proceedings.

[25]  B. Levine.  THE NATURE OF THE ANTIGEN-ANTIBODY COMPLEXES WHICH INITIATE ANAPHYLACTIC REACTIONS. II. THE EFFECT OF MOLECULAR SIZE ON THE ABILITIES OF HOMOLOGOUS MULTIVALENT BENZYLPENICILLOYL HAPTENS TO EVOKE PCA AND PASSIVE ARTHUS REACTIONS IN THE GUINEA PIG. , 1965, Journal of immunology.

[26]  H. Eisen,et al.  POLYFUNCTIONAL DINITROPHENYL HAPTENS AS REAGENTS FOR ELICITATION OF IMMEDIATE TYPE ALLERGIC SKIN RESPONSES , 1962, The Journal of experimental medicine.

[27]  S. E. Michael.  The isolation of albumin from blood serum or plasma by means of organic solvents. , 1962, The Biochemical journal.

[28]  H. Eisen,et al.  The Interaction of Dinitrobenzene Derivatives with Bovine Serum Albumin1,2 , 1953 .

[29]  F. Sanger,et al.  The free amino groups of haemoglobins. , 1948, The Biochemical journal.

[30]  H. Punnett,et al.  Lymphocytes in Congenital Absence of the Thymus , 1967, Nature.

[31]  J. Owen,et al.  Experimental studies on the development of the bursa of Fabricius. , 1966, Developmental biology.

[32]  G. B. Pierce,et al.  The development of basement membranes of the mouse embryo. , 1966, Developmental biology.

[33]  C. Janeway,et al.  The gamma globulins. 3. The antibody deficiency syndromes. , 1966, The New England journal of medicine.

[34]  M. Moore,et al.  Chromosome Marker Studies on the Development of the Haemopoietic System in the Chick Embryo , 1965, Nature.

[35]  C. Smith,et al.  STUDIES ON THE THYMUS OF THE MAMMAL. XIV. HISTOLOGY AND HISTOCHEMISTRY OF EMBRYONIC AND EARLY POSTNATAL THYMUSES OF C57BL-6 AND AKR STRAIN MICE. , 1965, The American journal of anatomy.

[36]  G. Ackerman,et al.  The epithelial origin of the lymphocytes in the thymus of the embryonic hamster , 1965, The Anatomical record.

[37]  D. Shepro,et al.  Ultrastructure of the fetal thymus in the golden hamster , 1964, Journal of morphology.

[38]  G. Ackerman,et al.  Lymphocyte formation in the thymus of the embryonic chick , 1964, The Anatomical record.

[39]  C. E. Ford,et al.  Cellular Traffic of the Thymus: Experiments with Chromosome Markers: Evidence from Parabiosis for an Afferent Stream of Cells , 1964, Nature.

[40]  R. Auerbach,et al.  Experimental analysis of the origin of cell types in the development of the mouse thymus. , 1961, Developmental biology.

[41]  R. Auerbach.  Morphogenetic interactions in the development of the mouse thymus gland. , 1960, Developmental biology.

[42]  C. Grégoire.  The Cultivation in the Living Organism of the Thymus Epithelium of the Guinea-Pig and Rat , 1958 .

[43]  J. H. Humphrey.  What are gamma globulins? , 1958, Lectures on the scientific basis of medicine.

[44]  A. Moscona.  THE DEVELOPMENT IN VITRO OF CHIMERIC AGGREGATES OF DISSOCIATED EMBRYONIC CHICK AND MOUSE CELLS. , 1957, Proceedings of the National Academy of Sciences of the United States of America.

[45]  W. S. Hammond.  Origin of thymus in the chick embryo , 1954 .

[46]  W. Venzke.  Morphogenesis of the thymus of chicken embryos. , 1952, American journal of veterinary research.

[47]  H. L. Hamilton,et al.  An experimental study of the origin of the parathyroid and thymus glands in the chick , 1952 .

[48]  N. Hancox.  The survival of transplanted embryo bone grafted to chorioallantoic membrane, and subsequent osteogenesis , 1947, The Journal of physiology.

[49]  C. Klapper.  The development of the pharynx of the guinea pig with special emphasis on the morphogenesis of the thymus. , 1946, The American journal of anatomy.

[50]  H. Jaffe,et al.  STUDIES ON THE HISTOGENESIS OF AUTOPLASTIC THYMUS TRANSPLANTATIONS , 1926, The Journal of experimental medicine.

[51]  J. Badertscher.  The development of the thymus in the pig. I. Morphogenesis , 1915 .