Is spatial occurrence of microsatellites in the genome a determinant of their function and dynamics contributing to genome evolution ?

The non-random distribution of microsatellites in the genome has been implicated in a number of cellular and evolutionary activities. Recently, microsatellites have gained much attention due to their suggested association with cancers, ageing and various other metabolic disorders. Microsatellites are thought to have evolved mainly through polymerase slippage with variable mutation rates. It is difficult to develop a typical molecular evolutionary model that may describe genomic dynamics of these sequence elements. Microsatellites may also be the accidental sites of action by selection forces in events like genome divergence and speciation. Substantial evidence is available to describe various life stages of microsatellite evolution. This review addresses the current state of knowledge suggesting interrelationships between genomic locations, functions and evolutionary dynamics of microsatellites, and their subsequent implications in genome evolution.

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