A computational diffusion model to study antibody transport within reconstructed tumor microenvironments

[1]  Yang Luo,et al.  Pharmacokinetics of pertuzumab administered concurrently with trastuzumab in Chinese patients with HER2-positive early breast cancer. , 2019, Anti-cancer drugs.

[2]  M. Karsdal,et al.  Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology , 2019, Journal of Experimental & Clinical Cancer Research.

[3]  F. Scheffold,et al.  Structure and Sedimentation Kinetics of Dense Suspensions of Fibroblast Cells. , 2019, Chimia.

[4]  M. Cragg,et al.  Through the barricades: overcoming the barriers to effective antibody-based cancer therapeutics. , 2018, Glycobiology.

[5]  W. Sommergruber,et al.  3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment. , 2018, Biomaterials.

[6]  Dan Peer,et al.  Progress and challenges towards targeted delivery of cancer therapeutics , 2018, Nature Communications.

[7]  Mauro Ferrari,et al.  Transport Barriers and Oncophysics in Cancer Treatment. , 2018, Trends in cancer.

[8]  Jordi Andilla,et al.  Light-sheet microscopy: a tutorial , 2018 .

[9]  Qihui Fan,et al.  Modeling three-dimensional invasive solid tumor growth in heterogeneous microenvironment under chemotherapy , 2018, PloS one.

[10]  K. Rejniak,et al.  Targeting Ligand Specificity Linked to Tumor Tissue Topological Heterogeneity via Single-Cell Micro-Pharmacological Modeling , 2018, Scientific Reports.

[11]  K. Rejniak,et al.  Micropharmacology: An In Silico Approach for Assessing Drug Efficacy Within a Tumor Tissue , 2018, Bulletin of Mathematical Biology.

[12]  L. Kremer,et al.  New Strategies Using Antibody Combinations to Increase Cancer Treatment Effectiveness , 2017, Front. Immunol..

[13]  Timothy W. Secomb,et al.  Transport of drugs from blood vessels to tumour tissue , 2017, Nature Reviews Cancer.

[14]  Junle Qu,et al.  Oriented collagen fibers direct tumor cell intravasation , 2016, Proceedings of the National Academy of Sciences.

[15]  V. Wroblewski,et al.  A Modeling and Experimental Investigation of the Effects of Antigen Density, Binding Affinity, and Antigen Expression Ratio on Bispecific Antibody Binding to Cell Surface Targets* , 2016, The Journal of Biological Chemistry.

[16]  P. Alves,et al.  Adaptable stirred-tank culture strategies for large scale production of multicellular spheroid-based tumor cell models. , 2016, Journal of biotechnology.

[17]  Xiaohong Zhou,et al.  Kinetic analysis of a high-affinity antibody/antigen interaction performed by planar waveguide fluorescence immunosensor , 2016 .

[18]  Simon T Barry,et al.  Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression. , 2016, Biomaterials.

[19]  B. Lum,et al.  Population pharmacokinetic and exposure–response analysis for trastuzumab administered using a subcutaneous “manual syringe” injection or intravenously in women with HER2-positive early breast cancer , 2015, Cancer Chemotherapy and Pharmacology.

[20]  Catarina Brito,et al.  SPIM-fluid: open source light-sheet based platform for high-throughput imaging. , 2015, Biomedical optics express.

[21]  M D'Incalci,et al.  Intratumor Heterogeneity and Its Impact on Drug Distribution and Sensitivity , 2014, Clinical pharmacology and therapeutics.

[22]  R M Phillips,et al.  Mathematical and computational models of drug transport in tumours , 2014, Journal of The Royal Society Interface.

[23]  J. Miyake,et al.  Measurement of Biomolecular Diffusion in Extracellular Matrix Condensed by Fibroblasts Using Fluorescence Correlation Spectroscopy , 2013, PloS one.

[24]  You Han Bae,et al.  Tumor heterogeneity and its implication for drug delivery. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[25]  Mauro Ferrari,et al.  Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors. , 2012, AIP advances.

[26]  Hari Shroff,et al.  Microscopy in 3D: a biologist's toolbox. , 2011, Trends in cell biology.

[27]  Ian F Tannock,et al.  The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors , 2010, BMC Cancer.

[28]  M. A. Croce,et al.  Hyaluronan uptake by adult human skin fibroblasts in vitro. , 2009, European journal of histochemistry : EJH.

[29]  I. Tannock,et al.  Drug penetration in solid tumours , 2006, Nature Reviews Cancer.

[30]  R. Jain,et al.  Measurement of macromolecular diffusion coefficients in human tumors. , 2004, Microvascular research.

[31]  Jan Vos,et al.  A flexible sigmoid function of determinate growth. , 2003, Annals of botany.

[32]  R. Jain,et al.  Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells , 2002, British Journal of Cancer.

[33]  Cynthia Sung,et al.  Computational Models of Antibody-Based Tumor Imaging and Treatment Protocols , 2001, Annals of Biomedical Engineering.

[34]  R. Jain,et al.  Role of extracellular matrix assembly in interstitial transport in solid tumors. , 2000, Cancer research.

[35]  R K Jain,et al.  Direct in vivo measurement of targeted binding in a human tumor xenograft. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[36]  X. Yang,et al.  Expression of CD44 in human lung tumors. , 1994, Cancer research.

[37]  R. Jain,et al.  Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues. , 1990, Cancer research.

[38]  R K Jain,et al.  Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors. , 1990, Cancer research.

[39]  F. Buchegger,et al.  Penetration and binding of radiolabeled anti-carcinoembryonic antigen monoclonal antibodies and their antigen binding fragments in human colon multicellular tumor spheroids. , 1987, Cancer research.

[40]  W. J. Jenkins Tracers of ocean mixing , 2014 .

[41]  J. Carlsson,et al.  Relations between the penetration, binding and average concentration of cytostatic drugs in human tumour spheroids , 2004, Cancer Chemotherapy and Pharmacology.

[42]  W. Jenkins 6.08 – Tracers of Ocean Mixing , 2003 .

[43]  M. Tabatabai,et al.  Theoretical Biology and Medical Modelling Open Access Hyperbolastic Growth Models: Theory and Application , 2022 .