Cannabinoid signalling regulates inflammation and energy balance: The importance of the brain–gut axis

[1]  M. Bueter,et al.  Gastrointestinal hormones, energy balance and bariatric surgery , 2011, International Journal of Obesity.

[2]  R. Reimer,et al.  Prebiotic fibres dose-dependently increase satiety hormones and alter Bacteroidetes and Firmicutes in lean and obese JCR:LA-cp rats , 2011, British Journal of Nutrition.

[3]  P. François,et al.  Altered Gut Microbiota and Endocannabinoid System Tone in Obese and Diabetic Leptin-Resistant Mice: Impact on Apelin Regulation in Adipose Tissue , 2011, Front. Microbio..

[4]  D. Piomelli,et al.  Endocannabinoid signal in the gut controls dietary fat intake , 2011, Proceedings of the National Academy of Sciences.

[5]  M. Fresno,et al.  Toll-like receptors, inflammation, metabolism and obesity , 2011, Archives of physiology and biochemistry.

[6]  Carey N Lumeng,et al.  Inflammatory links between obesity and metabolic disease. , 2011, The Journal of clinical investigation.

[7]  Patrice D Cani,et al.  The gut microbiome as therapeutic target. , 2011, Pharmacology & therapeutics.

[8]  J. Perrard,et al.  Effect of the Cannabinoid Receptor‐1 Antagonist Rimonabant on Inflammation in Mice With Diet‐Induced Obesity , 2011, Obesity.

[9]  G. Dockray,et al.  Plasticity in vagal afferent neurones during feeding and fasting: mechanisms and significance * , 2011, Acta physiologica.

[10]  Lindsay K. Eller,et al.  The neutral cannabinoid CB1 receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat , 2011, Pharmacology Biochemistry and Behavior.

[11]  D. Cai,et al.  Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress , 2011, Proceedings of the National Academy of Sciences.

[12]  L. Velloso,et al.  Inflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function* , 2011, The Journal of Biological Chemistry.

[13]  Stephen P. H. Alexander,et al.  International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 , 2010, Pharmacological Reviews.

[14]  B. Lutz,et al.  A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents , 2010, British journal of pharmacology.

[15]  Miguel Martín,et al.  Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age , 2010, Diabetologia.

[16]  B. Lutz,et al.  Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a Peripherally Restricted Cannabinoid CB1/CB2 Receptor Agonist, Inhibits Gastrointestinal Motility but Has No Effect on Experimental Colitis in Mice , 2010, Journal of Pharmacology and Experimental Therapeutics.

[17]  M. Schwartz,et al.  Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up. , 2010, Endocrinology.

[18]  J. Rutledge,et al.  Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. , 2010, American journal of physiology. Gastrointestinal and liver physiology.

[19]  F. Bäckhed,et al.  The endocannabinoid system links gut microbiota to adipogenesis , 2010, Molecular systems biology.

[20]  D. Thompson,et al.  Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype. , 2010, American journal of physiology. Gastrointestinal and liver physiology.

[21]  G. Muccioli.  Endocannabinoid biosynthesis and inactivation, from simple to complex. , 2010, Drug discovery today.

[22]  Q. Pittman,et al.  Cannabinoid CB2 Receptors in Health and Disease , 2010 .

[23]  U. Das,et al.  Obesity: genes, brain, gut, and environment. , 2010, Nutrition.

[24]  K. Simpson,et al.  The role of gut hormones and the hypothalamus in appetite regulation. , 2010, Endocrine journal.

[25]  E. Timofeeva,et al.  Palatable High‐Energy Diet Decreases the Expression of Cannabinoid Type 1 Receptor Messenger RNA in Specific Brain Regions in the Rat , 2009, Journal of neuroendocrinology.

[26]  R. Capasso,et al.  Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re‐feeding , 2009, British journal of pharmacology.

[27]  S. Woods,et al.  Food Intake‐independent Effects of CB1 Antagonism on Glucose and Lipid Metabolism , 2009, Obesity.

[28]  Andreas Zimmer,et al.  Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis , 2009, PloS one.

[29]  C. Chaumontet,et al.  A high-fat diet attenuates the central response to within-meal satiation signals and modifies the receptor expression of vagal afferents in mice. , 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

[30]  S. Collins,et al.  The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. , 2009, Gastroenterology.

[31]  E. Mayer,et al.  Principles and clinical implications of the brain–gut–enteric microbiota axis , 2009, Nature Reviews Gastroenterology &Hepatology.

[32]  J. Newman,et al.  Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats. , 2009, American journal of physiology. Endocrinology and metabolism.

[33]  T. van de Wiele,et al.  Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability , 2009, Gut.

[34]  A. Duranti,et al.  Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice. , 2009, Bioorganic & medicinal chemistry letters.

[35]  Masahiko Watanabe,et al.  Peripheral, but Not Central, CB1 Antagonism Provides Food Intake–Independent Metabolic Benefits in Diet-Induced Obese Rats , 2008, Diabetes.

[36]  G. Uhl,et al.  Behavioral Effects of CB2 Cannabinoid Receptor Activation and Its Influence on Food and Alcohol Consumption , 2008, Annals of the New York Academy of Sciences.

[37]  R. Bibiloni,et al.  Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice , 2008, Diabetes.

[38]  C. Apovian,et al.  Inducible Toll‐like Receptor and NF‐κB Regulatory Pathway Expression in Human Adipose Tissue , 2008, Obesity.

[39]  K. Mackie,et al.  Cannabinoid Receptors: Where They are and What They do , 2008, Journal of neuroendocrinology.

[40]  R. Capasso,et al.  Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets , 2008, Molecular and Cellular Endocrinology.

[41]  R. Capasso,et al.  The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high‐fat diet , 2008, British journal of pharmacology.

[42]  R. Capasso,et al.  Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High‐fat Diet , 2008, Obesity.

[43]  J. Salamone,et al.  The Novel Cannabinoid CB1 Receptor Neutral Antagonist AM4113 Suppresses Food Intake and Food-Reinforced Behavior but Does not Induce Signs of Nausea in Rats , 2008, Neuropsychopharmacology.

[44]  J. Carvalheira,et al.  Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance , 2007, Diabetes.

[45]  T. Croci,et al.  Effect of the cannabinoid CB1 receptor antagonist rimonabant on nociceptive responses and adjuvant‐induced arthritis in obese and lean rats , 2007, British journal of pharmacology.

[46]  V. Marzo,et al.  Endocannabinoids and the control of energy balance , 2007, Trends in Endocrinology & Metabolism.

[47]  S. Gaetani,et al.  Food Intake Regulates Oleoylethanolamide Formation and Degradation in the Proximal Small Intestine* , 2007, Journal of Biological Chemistry.

[48]  P. Turnbaugh,et al.  Microbial ecology: Human gut microbes associated with obesity , 2006, Nature.

[49]  E. Mardis,et al.  An obesity-associated gut microbiome with increased capacity for energy harvest , 2006, Nature.

[50]  M. Fasshauer,et al.  Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity , 2006, Diabetes.

[51]  J. Flier,et al.  TLR4 links innate immunity and fatty acid-induced insulin resistance. , 2006, The Journal of clinical investigation.

[52]  F. Pavón,et al.  Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole – LH 21 , 2006, Neuropharmacology.

[53]  M. Maj,et al.  Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia. , 2006, The Journal of clinical endocrinology and metabolism.

[54]  Q. Pittman,et al.  AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion , 2006, British journal of pharmacology.

[55]  L. Velloso,et al.  Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. , 2005, Endocrinology.

[56]  T. Suganami,et al.  A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes: Role of Free Fatty Acids and Tumor Necrosis Factor α , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[57]  P. Soubrié,et al.  The CB1 receptor antagonist rimonabant reverses the diet‐induced obesity phenotype through the regulation of lipolysis and energy balance , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[58]  J. Burston,et al.  CB1 cannabinoid receptor‐mediated modulation of food intake in mice , 2005, British journal of pharmacology.

[59]  K. Mackie,et al.  Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. , 2005, The Journal of clinical investigation.

[60]  Patrice D Cani,et al.  Impact of inulin and oligofructose on gastrointestinal peptides , 2005, British Journal of Nutrition.

[61]  Ting Wang,et al.  The gut microbiota as an environmental factor that regulates fat storage. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[62]  K. Sharkey,et al.  Cannabinoid (CB)1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rat , 2004, Physiology & Behavior.

[63]  P. Soubrié,et al.  CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity , 2004, International Journal of Obesity.

[64]  D. Thompson,et al.  Expression of Cannabinoid CB1 Receptors by Vagal Afferent Neurons Is Inhibited by Cholecystokinin , 2004, The Journal of Neuroscience.

[65]  U. Smith,et al.  High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator. , 2004, Obesity research.

[66]  M. Desai,et al.  Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.

[67]  P. Soubrié,et al.  The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. , 2003, Molecular pharmacology.

[68]  D. Piomelli,et al.  A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding , 2002, The Journal of Neuroscience.

[69]  V. Marzo,et al.  Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2‐arachidonoyl glycerol , 2002, British journal of pharmacology.

[70]  S. Gaetani,et al.  An anorexic lipid mediator regulated by feeding , 2001, Nature.

[71]  R. Palmiter,et al.  Leptin-regulated endocannabinoids are involved in maintaining food intake , 2001, Nature.

[72]  T. Bonner,et al.  Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[73]  G. Gessa,et al.  Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. , 1998, Life sciences.

[74]  Z. Vogel,et al.  Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. , 1995, Biochemical pharmacology.

[75]  D. Gibson,et al.  Isolation and structure of a brain constituent that binds to the cannabinoid receptor. , 1992, Science.

[76]  Stephen P. H. Alexander,et al.  The life cycle of the endocannabinoids: formation and inactivation. , 2009, Current topics in behavioral neurosciences.

[77]  B. Lutz,et al.  Genetic models of the endocannabinoid system. , 2009, Current topics in behavioral neurosciences.

[78]  V. Marzo.  Endocannabinoids: synthesis and degradation. , 2006 .

[79]  T. Sugiura,et al.  2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. , 1995, Biochemical and biophysical research communications.