Advances in Digital Breast Tomosynthesis.

OBJECTIVE Digital breast tomosynthesis (DBT) has rapidly emerged as an important new imaging tool that reduces the masking effect of overlapping fibroglandular tissue, thereby improving breast cancer detection. This article will review key features of DBT including technique, clinical implementation, and benign and malignant imaging findings. We will also present the benefits of DBT in screening, diagnostic workup, and image-guided biopsy. CONCLUSION Tomosynthesis improves interpretive performance and will likely replace conventional 2D mammography in clinical practice.

[1]  Richard E. Sharpe,et al.  Increased Cancer Detection Rate and Variations in the Recall Rate Resulting from Implementation of 3D Digital Breast Tomosynthesis into a Population-based Screening Program. , 2016, Radiology.

[2]  L. Tabár,et al.  Insights from the Breast Cancer Screening Trials: How Screening Affects the Natural History of Breast Cancer and Implications for Evaluating Service Screening Programs , 2015, The breast journal.

[3]  M. Mainiero,et al.  Detection of mammographically occult architectural distortion on digital breast tomosynthesis screening: initial clinical experience. , 2014, AJR. American journal of roentgenology.

[4]  Yit Yoong Lim,et al.  Accuracy of Digital Breast Tomosynthesis for Depicting Breast Cancer Subgroups in a UK Retrospective Reading Study (TOMMY Trial). , 2015, Radiology.

[5]  Woo Kyung Moon,et al.  Comparative evaluation of average glandular dose and breast cancer detection between single-view digital breast tomosynthesis (DBT) plus single-view digital mammography (DM) and two-view DM: correlation with breast thickness and density , 2014, European Radiology.

[6]  Enzo Galligioni,et al.  Breast screening with ultrasound in women with mammography-negative dense breasts: evidence on incremental cancer detection and false positives, and associated cost. , 2008, European journal of cancer.

[7]  David Gur,et al.  Digital breast tomosynthesis versus supplemental diagnostic mammographic views for evaluation of noncalcified breast lesions. , 2013, Radiology.

[8]  David Gur,et al.  Recall Rate Reduction with Tomosynthesis During Baseline Screening Examinations: An Assessment From a Prospective Trial. , 2015, Academic radiology.

[9]  Jean B. Cormack,et al.  Multiple bilateral circumscribed masses at screening breast US: consider annual follow-up. , 2013, Radiology.

[10]  C. D'Orsi,et al.  Diagnostic Performance of Digital versus Film Mammography for Breast-Cancer Screening , 2006 .

[11]  Anders Tingberg,et al.  Breast tomosynthesis: Accuracy of tumor measurement compared with digital mammography and ultrasonography , 2010, Acta radiologica.

[12]  Andriy I Bandos,et al.  Comparison of two-dimensional synthesized mammograms versus original digital mammograms alone and in combination with tomosynthesis images. , 2014, Radiology.

[13]  M. Sormani,et al.  Adjunct Screening With Tomosynthesis or Ultrasound in Women With Mammography-Negative Dense Breasts: Interim Report of a Prospective Comparative Trial. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  Andriy I. Bandos,et al.  Comparison of digital mammography alone and digital mammography plus tomosynthesis in a population-based screening program. , 2013, Radiology.

[15]  S. Ciatto,et al.  Integration of 3D digital mammography with tomosynthesis for population breast-cancer screening (STORM): a prospective comparison study. , 2013, The Lancet. Oncology.

[16]  Jung Hee Shin,et al.  Comparison between two-dimensional synthetic mammography reconstructed from digital breast tomosynthesis and full-field digital mammography for the detection of T1 breast cancer , 2016, European Radiology.

[17]  Madhavi Raghu,et al.  Tomosynthesis in the Diagnostic Setting: Changing Rates of BI-RADS Final Assessment over Time. , 2016, Radiology.

[18]  C. Merritt Combined Screening With Ultrasound and Mammography vs Mammography Alone in Women at Elevated Risk of Breast Cancer , 2009 .

[19]  E. Conant,et al.  Breast Cancer Screening Using Tomosynthesis and Digital Mammography in Dense and Nondense Breasts. , 2016, JAMA.

[20]  Andriy I Bandos,et al.  Two-view digital breast tomosynthesis screening with synthetically reconstructed projection images: comparison with digital breast tomosynthesis with full-field digital mammographic images. , 2014, Radiology.

[21]  Rhian Gabe,et al.  The randomized trials of breast cancer screening: what have we learned? , 2004, Radiologic clinics of North America.

[22]  S. Rose,et al.  Implementation of breast tomosynthesis in a routine screening practice: an observational study. , 2013, AJR. American journal of roentgenology.

[23]  Madhavi Raghu,et al.  Comparison of tomosynthesis plus digital mammography and digital mammography alone for breast cancer screening. , 2013, Radiology.

[24]  Phoebe E. Freer,et al.  Preoperative Tomosynthesis-guided Needle Localization of Mammographically and Sonographically Occult Breast Lesions. , 2015, Radiology.

[25]  I Sechopoulos,et al.  Review of radiation dose estimates in digital breast tomosynthesis relative to those in two-view full-field digital mammography. , 2015, Breast.

[26]  D. Kopans,et al.  Digital Breast Tomosynthesis: State of the Art. , 2015, Radiology.

[27]  G. Baird,et al.  Changes in recall type and patient treatment following implementation of screening digital breast tomosynthesis. , 2015, Radiology.

[28]  Bonnie N Joe,et al.  Suspicious Findings at Digital Breast Tomosynthesis Occult to Conventional Digital Mammography: Imaging Features and Pathology Findings , 2015, The breast journal.

[29]  Manuela Durando,et al.  Accuracy of mammography, digital breast tomosynthesis, ultrasound and MR imaging in preoperative assessment of breast cancer. , 2014, Anticancer research.

[30]  T. M. Kolb,et al.  Comparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluations. , 2002, Radiology.

[31]  A. Holland,et al.  Clinical performance metrics of 3D digital breast tomosynthesis compared with 2D digital mammography for breast cancer screening in community practice. , 2014, AJR. American journal of roentgenology.

[32]  S. Ahn,et al.  Digital breast tomosynthesis versus full-field digital mammography: comparison of the accuracy of lesion measurement and characterization using specimens , 2014, Acta radiologica.

[33]  J. Cha,et al.  Assessment of extent of breast cancer: comparison between digital breast tomosynthesis and full-field digital mammography. , 2013, Clinical radiology.

[34]  L. Philpotts,et al.  Screening US in patients with mammographically dense breasts: initial experience with Connecticut Public Act 09-41. , 2012, Radiology.

[35]  Federica Zanca,et al.  Two-view and single-view tomosynthesis versus full-field digital mammography: high-resolution X-ray imaging observer study. , 2012, Radiology.

[36]  Daniel F Heitjan,et al.  Screening outcomes following implementation of digital breast tomosynthesis in a general-population screening program. , 2014, Journal of the National Cancer Institute.

[37]  S. Ciatto,et al.  Accuracy of tumour size assessment in the preoperative staging of breast cancer: comparison of digital mammography, tomosynthesis, ultrasound and MRI , 2013, La radiologia medica.

[38]  L. Philpotts,et al.  Tomosynthesis-detected Architectural Distortion: Management Algorithm with Radiologic-Pathologic Correlation. , 2016, Radiographics : a review publication of the Radiological Society of North America, Inc.

[39]  KathleenR. Brandt,et al.  Can digital breast tomosynthesis replace conventional diagnostic mammography views for screening recalls without calcifications? A comparison study in a simulated clinical setting. , 2013, AJR. American journal of roentgenology.

[40]  Jean B. Cormack,et al.  Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer. , 2008, JAMA.

[41]  Emily F Conant,et al.  Breast cancer screening using tomosynthesis in combination with digital mammography. , 2014, JAMA.

[42]  Pragya A. Dang,et al.  Addition of tomosynthesis to conventional digital mammography: effect on image interpretation time of screening examinations. , 2014, Radiology.

[43]  Phoebe E. Freer,et al.  Digital breast tomosynthesis in the analysis of fat-containing lesions. , 2014, Radiographics : a review publication of the Radiological Society of North America, Inc.

[44]  C. Waldherr,et al.  Tomosynthesis-guided vacuum-assisted breast biopsy: A feasibility study , 2016, European Radiology.

[45]  P. Porter,et al.  Breast density as a predictor of mammographic detection: comparison of interval- and screen-detected cancers. , 2000, Journal of the National Cancer Institute.

[46]  Barbara L. Smith,et al.  A failure analysis of invasive breast cancer: Most deaths from disease occur in women not regularly screened , 2014, Cancer.

[47]  Anne Marie McCarthy,et al.  Baseline Screening Mammography: Performance of Full-Field Digital Mammography Versus Digital Breast Tomosynthesis. , 2015, AJR. American journal of roentgenology.

[48]  Tor D Tosteson,et al.  Digital breast tomosynthesis: initial experience in 98 women with abnormal digital screening mammography. , 2007, AJR. American journal of roentgenology.

[49]  Pavel Crystal,et al.  Using sonography to screen women with mammographically dense breasts. , 2003, AJR. American journal of roentgenology.

[50]  Madhavi Raghu,et al.  Early clinical experience with digital breast tomosynthesis for screening mammography. , 2015, Radiology.

[51]  Anne Marie McCarthy,et al.  Breast cancer screening using tomosynthesis in combination with digital mammography compared to digital mammography alone: a cohort study within the PROSPR consortium , 2016, Breast Cancer Research and Treatment.

[52]  Andrew Oustimov,et al.  Effectiveness of Digital Breast Tomosynthesis Compared With Digital Mammography: Outcomes Analysis From 3 Years of Breast Cancer Screening. , 2016, JAMA oncology.

[53]  Anders Tingberg,et al.  Performance of one-view breast tomosynthesis as a stand-alone breast cancer screening modality: results from the Malmö Breast Tomosynthesis Screening Trial, a population-based study , 2015, European Radiology.

[54]  Simone Schrading,et al.  Digital breast tomosynthesis-guided vacuum-assisted breast biopsy: initial experiences and comparison with prone stereotactic vacuum-assisted biopsy. , 2015, Radiology.

[55]  J. Baker,et al.  Architectural Distortion on Mammography: Correlation With Pathologic Outcomes and Predictors of Malignancy. , 2015, AJR. American journal of roentgenology.

[56]  E A Sickles,et al.  Malignant breast masses detected only by ultrasound: A retrospective review , 1996, Cancer.

[57]  E A Sickles,et al.  Multiple bilateral masses detected on screening mammography: assessment of need for recall imaging. , 2000, AJR. American journal of roentgenology.