Clinical Study and Literature Review of Nasal Irrigation

Objectives/Hypothesis Nasal disease, including chronic rhinosinusitis and allergic rhinitis, is a significant source of morbidity. Nasal irrigation has been used as an adjunctive treatment of sinonasal disease. However, despite an abundance of anecdotal reports, there has been little statistical evidence to support its efficacy. The objective of this study was to determine the efficacy of the use of pulsatile hypertonic saline nasal irrigation in the treatment of sinonasal disease.

[1]  M. Grossan.  A new nasal irrigator device. , 1974, Eye, ear, nose & throat monthly.

[2]  D. Shoseyov,et al.  Treatment with hypertonic saline versus normal saline nasal wash of pediatric chronic sinusitis. , 1998, The Journal of allergy and clinical immunology.

[3]  E. Toskala,et al.  Scanning electron microscopy findings of human respiratory cilia in chronic sinusitis and in recurrent respiratory infections , 1995, The Journal of Laryngology & Otology.

[4]  C. Berry,et al.  Classifying Function for Health Outcome and Quality-of-life Evaluation: Self- Versus Interviewer Modes , 1986, Medical care.

[5]  E. Meltzer,et al.  Prevalence of allergic rhinitis in the United States , 1997 .

[6]  T. Davidson,et al.  Rapid clinical evaluation of anosmia. The alcohol sniff test. , 1997, Archives of otolaryngology--head & neck surgery.

[7]  R. Sly.  Changing prevalence of allergic rhinitis and asthma. , 1999, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[8]  R. Mabry.  Therapeutic agents in the medical management of sinusitis. , 1993, Otolaryngologic clinics of North America.

[9]  R. Naclerio,et al.  Sinusitis: bench to bedside. Current findings, future directions. , 1997, The Journal of allergy and clinical immunology.

[10]  David S. Parsons.  Chronic sinusitis: a medical or surgical disease? , 1996, Otolaryngologic clinics of North America.

[11]  R. Barton.  Atrophic Rhinitis , 1992, The Journal of Laryngology & Otology.

[12]  R. Blake,et al.  A clinical trial of hypertonic saline nasal spray in subjects with the common cold or rhinosinusitis. , 1998, Archives of family medicine.

[13]  David S. Parsons,et al.  Mucociliary Clearance and Buffered Hypertonic Saline Solution , 1997, The Laryngoscope.

[14]  R. Naclerio,et al.  Sinusitis: bench to bedside. Current findings, future directions. , 1997, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[15]  R. Zeiger.  Prospects for ancillary treatment of sinusitis in the 1990s. , 1992, The Journal of allergy and clinical immunology.

[16]  S. Karman,et al.  Treatment of perennial allergic rhinitis by local hyperthermia. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[17]  B. Ferguson.  Allergic rhinitis. Options for pharmacotherapy and immunotherapy. , 1997, Postgraduate medicine.

[18]  J. Forrest,et al.  Nasal ciliary ultrastructure and function in patients with primary ciliary dyskinesia compared with that in normal subjects and in subjects with various respiratory diseases. , 1984, The American review of respiratory disease.

[19]  D. Tyrrell,et al.  Local hyperthermia benefits natural and experimental common colds. , 1989, BMJ.

[20]  J. Georgitis.  Local hyperthermia and nasal irrigation for perennial allergic rhinitis: effect on symptoms and nasal airflow. , 1993, Annals of allergy.

[21]  T. Davidson,et al.  Management of chronic sinusitis in cystic fibrosis , 1995, The Laryngoscope.

[22]  R. Garibaldi,et al.  Epidemiology of community-acquired respiratory tract infections in adults , 1985, The American Journal of Medicine.

[23]  R. Metson,et al.  Techniques for outcomes research in chronic sinusitis , 1995, The Laryngoscope.

[24]  J. Georgitis.  Nasal hyperthermia and simple irrigation for perennial rhinitis. Changes in inflammatory mediators. , 1994, Chest.

[25]  V. Benson,et al.  Current estimates from the National Health Interview Survey, 1992. , 1994, Vital and health statistics. Series 10, Data from the National Health Survey.

[26]  R M Kaplan,et al.  Health status: types of validity and the index of well-being. , 1976, Health services research.

[27]  C. Berry,et al.  Internal Consistency Analysis: a method for studying the accuracy of function assessment for health outcome and quality of life evaluation. , 1988, Journal of clinical epidemiology.

[28]  Robert A. Nathan,et al.  The economic impact of allergic rhinitis , 1997 .

[29]  G. Christensen,et al.  The Efficacy of Various Irrigation Solutions in Removing Slime-Producing Staphylococcus , 1994, Journal of orthopaedic trauma.