New neurons: extraordinary evidence or extraordinary conclusion?

Gould et al . ([1][1]) reported that in the adult primate new neurons may be added to some neocortical association areas. This remarkable finding explicitly challenges previous work indicating that the production of new neurons in the primate neocortex is limited to the fetal period ([2][2]), and,

[1]  N. L. Hayes,et al.  Exploiting the Dynamics of S-Phase Tracers in Developing Brain: Interkinetic Nuclear Migration for Cells Entering versus Leavingthe S-Phase , 2000, Developmental Neuroscience.

[2]  N. Tamamaki,et al.  Cell migration from the ganglionic eminence to the neocortex investigated by labeling nuclei with UV irradiation via a fiber-optic cable , 1999, Neuroscience Research.

[3]  C. Gross,et al.  Neurogenesis in the neocortex of adult primates. , 1999, Science.

[4]  S. Hockfield,et al.  A family of proteins implicated in axon guidance and outgrowth. , 1999, Journal of neurobiology.

[5]  P. Goldman-Rakic,et al.  Increased volume and glial density in primate prefrontal cortex associated with chronic antipsychotic drug exposure , 1999, Biological Psychiatry.

[6]  A. Kakita,et al.  Patterns and Dynamics of SVZ Cell Migration in the Postnatal Forebrain Monitoring Living Progenitors in Slice Preparations , 1999, Neuron.

[7]  P. Rakić,et al.  Continuation of neurogenesis in the hippocampus of the adult macaque monkey. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[8]  V. Caviness,et al.  Review : Cell Cycle as Operational Unit of Neocortical Neuronogenesis , 1999 .

[9]  E. Gould,et al.  Learning enhances adult neurogenesis in the hippocampal formation , 1999, Nature Neuroscience.

[10]  F. Gage,et al.  Neurogenesis in the adult human hippocampus , 1998, Nature Medicine.

[11]  N. Copeland,et al.  Isolation and characterization of a bovine neural specific protein (CRMP-2) cDNA homologous to unc-33, a C. elegans gene implicated in axonal outgrowth and guidance. , 1998, Brain research. Molecular brain research.

[12]  P. Rakic,et al.  Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex , 1998, The Journal of Neuroscience.

[13]  P. Rakić,et al.  Changes in cell-cycle kinetics during the development and evolution of primate neocortex. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[14]  J. Deloulme,et al.  Expression of two neuronal markers, growth-associated protein 43 and neuron-specific enolase, in rat glial cells , 1997, Journal of Molecular Medicine.

[15]  F. Gage,et al.  More hippocampal neurons in adult mice living in an enriched environment , 1997, Nature.

[16]  S. Mcconnell,et al.  Postmitotic neurons migrate tangentially in the cortical ventricular zone. , 1997, Development.

[17]  S. Dunnett,et al.  Co-expression of MAP-2 and GFAP in cells developing from rat EGF responsive precursor cells. , 1997, Brain research. Developmental brain research.

[18]  Takao Takahashi,et al.  Interkinetic and Migratory Behavior of a Cohort of Neocortical Neurons Arising in the Early Embryonic Murine Cerebral Wall , 1996, The Journal of Neuroscience.

[19]  A. Keller,et al.  Expression of the Neuron‐Specific Enolase Gene by Rat Oligodendroglial Cells During Their Differentiation , 1996, Journal of neurochemistry.

[20]  Arturo Alvarez-Buylla,et al.  Chain Migration of Neuronal Precursors , 1996, Science.

[21]  V. Caviness,et al.  The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[22]  H. Dodt,et al.  Novel forms of neuronal migration in the rat cerebellum , 1995, Journal of neuroscience research.

[23]  C. Lois,et al.  Long-distance neuronal migration in the adult mammalian brain. , 1994, Science.

[24]  S. Mcconnell,et al.  Cell migration in cultured cerebral cortical slices. , 1993, Developmental biology.

[25]  S. Mcconnell,et al.  Diverse migratory pathways in the developing cerebral cortex. , 1992, Science.

[26]  R. J. Mullen,et al.  NeuN, a neuronal specific nuclear protein in vertebrates. , 1992, Development.

[27]  P. Levitt,et al.  Persistence of fluoro-gold following degeneration of labeled motoneurons is due to phagocytosis by microglia and macrophages , 1991, Neuroscience.

[28]  G. Fishell,et al.  Astrotactin provides a receptor system for CNS neuronal migration. , 1991, Development.

[29]  M. Miller,et al.  Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population , 1989, Journal of neurocytology.

[30]  P. Rakić.  Limits of neurogenesis in primates. , 1985, Science.

[31]  S. Hsu,et al.  Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. , 1981, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[32]  P. Rakić,et al.  The site of origin and route and rate of migration of neurons to the hippocampal region of the rhesus monkey , 1981, The Journal of comparative neurology.

[33]  P. Rakić.  Neurons in Rhesus Monkey Visual Cortex: Systematic Relation between Time of Origin and Eventual Disposition , 1974, Science.

[34]  W. W. Nichols,et al.  Statistical confirmation that immunofluorescent detection of DNA repair in human fibroblasts by measurement of bromodeoxyuridine incorporation is stoichiometric and sensitive. , 1993, Cytometry.

[35]  Kaplan Ms.  Proliferation of subependymal cells in the adult primate CNS: differential uptake of DNA labelled precursors. , 1983 .