INVITED REVIEW ON THE USE OF CHEMICALLY STRUCTURED MODELS FOR BIOREACTORS

An individual cell is an immensely complicated self-regulated chemical reactor that can alter its biosynthetic machinery to meet the demands of a changing environment. The biochemical engineer must build a large macroscopic reactor to harness the cells for desirable chemical conversions. The design and control of such bioreactors would be facilitated with effective mathematical models of the response of the culture to changes in nutrients or other environmental variables. Because of the inherent internal plasticity of the cell, models must reflect the changing structure of the biomass. This paper reviews some examples of models which contain components representing various chemical fractions within the cell. The advantage of these models is their potential ability to predict the dynamic behavior of a cellular population. In addition such models are potential tools for testing hypotheses concerning cellular control mechanisms and consequently the development of more effective cell strains. Models of popula...

[1]  Jeffrey W. Roberts,et al.  遺伝子の分子生物学 = Molecular biology of the gene , 1970 .

[2]  M M Domach,et al.  Computer model for glucose‐limited growth of a single cell of Escherichia coli B/r‐A , 1984, Biotechnology and bioengineering.

[3]  D. Ramkrishna.  A Cybernetic Perspective of Microbial Growth , 1983 .

[4]  F. M. Williams,et al.  A model of cell growth dynamics. , 1967, Journal of theoretical biology.

[5]  A. L. Koch,et al.  A model for statistics of the cell division process. , 1962, Journal of general microbiology.

[6]  M M Domach,et al.  Testing of a potential mechanism for E. coli temporal cycle imprecision with a structural model. , 1984, Journal of theoretical biology.

[7]  I. J. Harris,et al.  A model for noninhibitory microbial growth , 1982, Biotechnology and bioengineering.

[8]  H. M. Tsuchiya,et al.  Statistics and dynamics of microbial cell populations. , 1966 .

[9]  Armin Fiechter,et al.  Continuous cultivation of Saccharomyces cerevisiae. I. Growth on ethanol under steady‐state conditions , 1968 .

[10]  S. Cooper,et al.  Chromosome replication and the division cycle of Escherichia coli B/r. , 1968, Journal of molecular biology.

[11]  C. Helmstetter,et al.  Initiation of chromosome replication in Escherichia coli. II. Analysis of the control mechanism. , 1974, Journal of molecular biology.

[12]  J. E. Bailey,et al.  Bacterial population dynamics in batch and continuous-flow microbial reactors , 1981 .

[13]  A. Campbell,et al.  SYNCHRONIZATION OF CELL DIVISION , 1957, Bacteriological reviews.

[14]  M M Ataai,et al.  Double-substrate-limited growth of escherichia coli. , 1984, Biotechnology and bioengineering.

[15]  James E. Bailey,et al.  A mathematical model for λdv plasmid replication: Analysis of copy number mutants , 1984 .

[16]  M M Domach,et al.  A finite representation model for an asynchronous culture of E. coli , 1984, Biotechnology and bioengineering.

[17]  T. Imanaka,et al.  A kinetic model of catabolite repression in the dual control mechanism in microorganisms. , 1977, Biotechnology and bioengineering.

[18]  G T Daigger,et al.  An assessment of the role of physiological adaptation in the transient response of bacterial cultures , 1982, Biotechnology and bioengineering.

[19]  Doraiswami Ramkrishna,et al.  Dynamics of microbial propagation: Models considering inhibitors and variable cell composition , 1967 .

[20]  M. Bazin,et al.  Microbial population dynamics , 1982 .

[21]  A. Harder,et al.  Application of simple structured models in bioengineering , 1982 .

[22]  J E Bailey,et al.  Kinetics of Product Formation and Plasmid Segregation in Recombinant Microbial Populations , 1983, Annals of the New York Academy of Sciences.

[23]  A. G. Marr,et al.  Growth and division of Escherichia coli , 1966, Journal of bacteriology.

[24]  C. Woldringh,et al.  Changes in cell diameter during the division cycle of Escherichia coli , 1980, Journal of bacteriology.

[25]  A. L. Koch,et al.  Growth, cell and nuclear divisions in some bacteria. , 1962, Journal of general microbiology.

[26]  J. A. Burns,et al.  Causality, Complexity and Computers , 1968 .

[27]  A Constantinides,et al.  Modeling the role of cyclic AMP in catabolite repression of inducible enzyme biosynthesis in mircobial cells , 1978, Biotechnology and bioengineering.

[28]  Lilia Alberghina,et al.  ANALYSIS OF PROTEIN DISTRIBUTION IN POPULATIONS OF BUDDING YEAST BASED ON A STRUCTURED MODEL OF CELL GROWTH , 1983 .

[29]  Michael L. Shuler,et al.  Mathematical Models of the Growth of Individual Cells: Tools for Testing Biochemical Mechanisms , 1983 .

[30]  Michael L. Shuler,et al.  A MATHEMATICAL MODEL FOR THE GROWTH OF A SINGLE BACTERIAL CELL * , 1979 .

[31]  M M Ataai,et al.  Simulation of CFSTR through development of a mathematical model for anaerobic growth of Escherichia coli cell population , 1985, Biotechnology and bioengineering.

[32]  W. Donachie,et al.  Relationship between Cell Size and Time of Initiation of DNA Replication , 1968, Nature.

[33]  H. M. Tsuchiya,et al.  Dynamics of Microbial Cell Populations , 1966 .

[34]  H. M. Tsuchiya,et al.  Continuous propagation of microorganisms , 1963 .

[35]  James E. Bailey,et al.  On the dynamics of Cooper-Helmstetter-Donachie procaryote populations , 1980 .

[36]  A G Fredrickson,et al.  Formulation of structured growth models. , 2000, Biotechnology and bioengineering.

[37]  M. Moo-young,et al.  Cell growth and extracellular enzyme synthesis in fermentations , 1973, Biotechnology and bioengineering.

[38]  James E. Bailey,et al.  A mathematical model for λdv plasmid replication: Analysis of wild-type plasmid , 1984 .

[39]  M M Ataai,et al.  Simulation of the growth pattern of a single cell of Escherichia coli under anaerobic conditions , 1985, Biotechnology and bioengineering.

[40]  J E Bailey,et al.  Analysis of growth rate effects on productivity of recombinant Escherichia coli populations using molecular mechanism models , 1984, Biotechnology and bioengineering.