Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPARγ in carbon tetrachloride-treated mice.

[1]  H. Xin,et al.  Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice , 2022, Stem cell research & therapy.

[2]  Shan Huang,et al.  Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice. , 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[3]  Zuhair M. Mohammedsaleh,et al.  Thymus fontanesii attenuates CCl4-induced oxidative stress and inflammation in mild liver fibrosis. , 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[4]  Yingxue Zhang,et al.  The role of Glabridin in antifungal and anti-inflammation effects in Aspergillus fumigatus keratitis. , 2021, Experimental eye research.

[5]  Z. Meng,et al.  Endothelial c‐Myc knockout enhances diet‐induced liver inflammation and fibrosis , 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[6]  Yuting Li,et al.  Geniposide Ameliorates Liver Fibrosis Through Reducing Oxidative Stress and Inflammatory Respose, Inhibiting Apoptosis and Modulating Overall Metabolism , 2021, Frontiers in Pharmacology.

[7]  Lijun Zhang,et al.  Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF‐1α/SLC7A11 pathway , 2021, Cell proliferation.

[8]  D. Goltz,et al.  Smad7 Deficiency in Myeloid Cells Does Not Affect Liver Injury, Inflammation or Fibrosis after Chronic CCl4 Exposure in Mice , 2021, International journal of molecular sciences.

[9]  P. Seale,et al.  ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes , 2021, Genes & development.

[10]  A. K. Shendge,et al.  Ameliorating effects of white mulberry on iron-overload-induced oxidative stress and liver fibrosis in Swiss albino mice. , 2021, Food and Chemical Toxicology.

[11]  Amit Kumar,et al.  Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress , 2021, Drug and chemical toxicology.

[12]  Chuanyong Guo,et al.  The Agonists of Peroxisome Proliferator-Activated Receptor-γ for Liver Fibrosis , 2021, Drug design, development and therapy.

[13]  Yangyang Bian,et al.  S100A4 enhances protumor macrophage polarization by control of PPAR-γ-dependent induction of fatty acid oxidation , 2021, Journal for ImmunoTherapy of Cancer.

[14]  L. Xia,et al.  EZH2‐mediated inhibition of KLF14 expression promotes HSCs activation and liver fibrosis by downregulating PPARγ , 2021, Cell proliferation.

[15]  Amit Kumar,et al.  Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis. , 2021, Life sciences.

[16]  Wei Zhang,et al.  Tectorigenin alleviates intrahepatic cholestasis by inhibiting hepatic inflammation and bile accumulation via activation of PPARγ , 2021, British journal of pharmacology.

[17]  P. Cheng,et al.  PPARγ/NF‐κB and TGF‐β1/Smad pathway are involved in the anti‐fibrotic effects of levo‐tetrahydropalmatine on liver fibrosis , 2021, Journal of cellular and molecular medicine.

[18]  A. Richardson,et al.  Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress. , 2021, Free radical biology & medicine.

[19]  Yu Sun,et al.  Glabridin inhibits osteoarthritis development by protecting chondrocytes against oxidative stress, apoptosis and promoting mTOR mediated autophagy. , 2021, Life sciences.

[20]  Bin Liu,et al.  Indoleamine 2,3-dioxygenase 1 limits hepatic inflammatory cells recruitment and promotes bile duct ligation-induced liver fibrosis , 2021, Cell death & disease.

[21]  Kan Chen,et al.  Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γ/TGF-β Pathway , 2020, PPAR research.

[22]  G. Appendino,et al.  Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in mice. , 2020, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[23]  Yuehua Wu,et al.  Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression. , 2020, International immunopharmacology.

[24]  Xiao-Yun Li,et al.  Regulation of peroxisome proliferator-activated receptor-gamma activity affects the hepatic stellate cell activation and the progression of NASH via TGF-β1/Smad signaling pathway , 2020, Journal of Physiology and Biochemistry.

[25]  Kang Chen,et al.  Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[26]  Jingya Gu,et al.  Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner , 2020, Oxidative medicine and cellular longevity.

[27]  J. Chhimwal,et al.  Crocin attenuates CCl4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats , 2020, Human & experimental toxicology.

[28]  Jinhang Zhang,et al.  Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells , 2020, Hepatology.

[29]  Xiao-ming Meng,et al.  MicroRNA‐708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88 , 2020, Journal of cellular and molecular medicine.

[30]  M. Karsdal,et al.  Review article: the signalling and functional role of the extracellular matrix in the development of liver fibrosis , 2020, Alimentary pharmacology & therapeutics.

[31]  Songqing He,et al.  Tetramethylpyrazine ameliorates hepatic fibrosis through autophagy-mediated inflammation. , 2020, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[32]  R. Weiskirchen,et al.  Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases , 2019, Front. Immunol..

[33]  Minghua Deng,et al.  TIM‐4 interference in Kupffer cells against CCL4‐induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway , 2019, Cell proliferation.

[34]  Ling-ling Zhao,et al.  Celastrol exerts anti‐inflammatory effect in liver fibrosis via activation of AMPK‐SIRT3 signalling , 2019, Journal of cellular and molecular medicine.

[35]  Feng Zhang,et al.  Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner. , 2019, International immunopharmacology.

[36]  H. Gu,et al.  Osteoprotegerin Promotes Liver Steatosis by Targeting the ERK–PPAR-γ–CD36 Pathway , 2019, Diabetes.

[37]  Uraporn Vongvatcharanon,et al.  Effect of glabridin on collagen deposition in liver and amelioration of hepatocyte destruction in diabetes rats , 2019, Experimental and therapeutic medicine.

[38]  S. Friedman,et al.  Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury. , 2019, Journal of hepatology.

[39]  Ning Zhang,et al.  p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species , 2019, Theranostics.

[40]  J. Lykkesfeldt,et al.  A role of peroxisome proliferator‐activated receptor γ in non‐alcoholic fatty liver disease , 2019, Basic & clinical pharmacology & toxicology.

[41]  Jianren Gu,et al.  Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling , 2019, EBioMedicine.

[42]  Zhenlin Huang,et al.  Lonicera japonica Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Mice: Molecular Mechanisms of Action. , 2019, The American journal of Chinese medicine.

[43]  V. Narayanankutty,et al.  Glutathione, an antioxidant tripeptide: Dual roles in Carcinogenesis and Chemoprevention. , 2019, Current protein & peptide science.

[44]  Yunhe Fu,et al.  Protective Effect of Naringin on DSS-Induced Ulcerative Colitis in Mice. , 2018, Journal of agricultural and food chemistry.

[45]  G. Medina-Gómez,et al.  Maintenance of Kidney Metabolic Homeostasis by PPAR Gamma , 2018, International journal of molecular sciences.

[46]  W. Zhou,et al.  Glabridin, an isoflavan from licorice root, ameliorates imiquimod‐induced psoriasis‐like inflammation of BALB/c mice , 2018, International immunopharmacology.

[47]  P. Olinga,et al.  Targeting Oxidative Stress for the Treatment of Liver Fibrosis. , 2018, Reviews of physiology, biochemistry and pharmacology.

[48]  J. Rebhun,et al.  Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ). , 2015, Fitoterapia.

[49]  M. Uribe,et al.  The Role of Dendritic Cells in Fibrosis Progression in Nonalcoholic Fatty Liver Disease , 2015, BioMed research international.