p300/CBP Acts as a Coactivator to Cartilage Homeoprotein‐1 (Cart1), Paired‐Like Homeoprotein, Through Acetylation of the Conserved Lysine Residue Adjacent to the Homeodomain

The paired‐like homeoprotein, Cart1, is involved in skeletal development. We describe here that the general coactivator p300/CBP controls the transcription activity of Cart1 through acetylation of a lysine residue that is highly conserved in other homeoproteins. Acetylation of this residue increases the interaction between p300/CBP and Cart1 and enhances its transcriptional activation.

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