Maturation of human cerebrum observed in vivo during adolescence.

In the present study using magnetic resonance imaging (MRI), age changes in the morphology of the cerebral cortex, greatest in the frontal and parietal convexities, were observed during adolescence. Results suggest that increases in cerebrospinal fluid (CSF) within the sulci of these cortical regions accompany grey matter decreases. Smaller reductions in volume are also observed in subcortical grey matter nuclei. These apparent grey matter volume reductions presumably reflect processes of late brain maturation. The changes may be related to decreasing neural plasticity.

[1]  L. Sokoloff,et al.  An adaptation of the nitrous oxide method to the study of the cerebral circulation in children; normal values for cerebral blood flow and cerebral metabolic rate in childhood. , 1957, The Journal of clinical investigation.

[2]  P. Yakovlev,et al.  The myelogenetic cycles of regional maturation of the brain , 1967 .

[3]  L. Sokoloff,et al.  Blood flow to white matter during maturation of the brain , 1970, Neurology.

[4]  E. Heinz,et al.  Radiology of the Skull and Brain: The Skull , 1972 .

[5]  J. Changeux,et al.  Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks , 1976, Nature.

[6]  V. R. Carlson,et al.  Changes in EEG Amplitude During Sleep with Age , 1977 .

[7]  W. Stumpf.  Anatomical Distribution of Estrogen, Androgen, Progestin, Corticosteroid and Thyroid Hormone Target Sites in the Brain of Mammals: Phylogeny and Ontogeny , 1978 .

[8]  P. Huttenlocher.  Synaptic density in human frontal cortex - developmental changes and effects of aging. , 1979, Brain research.

[9]  D. Purves,et al.  Elimination of synapses in the developing nervous system. , 1980, Science.

[10]  H. Loos,et al.  Synaptogenesis in human visual cortex — evidence for synapse elimination during normal development , 1982, Neuroscience Letters.

[11]  B. McEwen,et al.  Estradiol receptor levels in rat hypothalamic and limbic nuclei , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[12]  I. Feinberg,et al.  Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? , 1982, Journal of psychiatric research.

[13]  A. Arnold,et al.  Gonadal steroid induction of structural sex differences in the central nervous system. , 1984, Annual review of neuroscience.

[14]  J. Fawcett,et al.  Regressive events in neurogenesis. , 1984, Science.

[15]  S. Easter,et al.  The changing view of neural specificity. , 1985, Science.

[16]  G A Johnson,et al.  MRI of brain iron. , 1986, AJR. American journal of roentgenology.

[17]  T. H. Newton,et al.  MRI of normal brain maturation. , 1986, AJNR. American journal of neuroradiology.

[18]  M. Phelps,et al.  Maturational changes in cerebral function in infants determined by 18FDG positron emission tomography. , 1986, Science.

[19]  P. Goldman-Rakic,et al.  Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex. , 1986, Science.

[20]  J. Mazziotta,et al.  Positron emission tomography study of human brain functional development , 1987, Annals of neurology.

[21]  I. Feinberg.  Adolescence and mental illness. , 1987, Science.

[22]  C. McArdle,et al.  Developmental features of the neonatal brain: MR imaging. Part II. Ventricular size and extracerebral space. , 1987, Radiology.

[23]  C. McArdle,et al.  Developmental features of the neonatal brain: MR imaging. Part I. Gray-white matter differentiation and myelination. , 1987, Radiology.

[24]  P. Huttenlocher,et al.  The development of synapses in striate cortex of man. , 1987, Human neurobiology.

[25]  B. Drayer,et al.  Imaging of the aging brain. Part I. Normal findings. , 1988, Radiology.

[26]  R Kikinis,et al.  Developmental stages of human brain: an MR study. , 1988, Journal of computer assisted tomography.

[27]  D. Norman,et al.  Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T. , 1988, Radiology.

[28]  H. Kinney,et al.  Sequence of Central Nervous System Myelination in Human Infancy. II. Patterns of Myelination in Autopsied Infants , 1988, Journal of neuropathology and experimental neurology.

[29]  K. Yamashita,et al.  Development and aging of brain midline structures: assessment with MR imaging. , 1989, Radiology.

[30]  G. Press,et al.  Methods for measuring brain morphologic features on magnetic resonance images. Validation and normal aging. , 1990, Archives of neurology.

[31]  T. Jernigan,et al.  LATE CHILDHOOD CHANGES IN BRAIN MORPHOLOGY OBSERVABLE WITH MRI , 1990, Developmental medicine and child neurology.

[32]  A. Elster,et al.  Pituitary gland: MR imaging of physiologic hypertrophy in adolescence. , 1990, Radiology.