Electron Capture Gas Chromatographic Assay for Miconazole and Clotrimazole In Skin Samples

Abstract Electron capture gas chromatographic assay procedures were developed for quantitating the antifungal agents clotrimazole and miconazole. The procedures were specifically developed for analysis of the drugs in superficial samples of human skin. The analytical methods were sensitive to 5 ng of miconazole and 10 ng clotrimazole per tissue sample.

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