Excessive production of hydrogen peroxide in mitochondria contributes to atopic dermatitis.
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F. Gruber | J. Hagenbuchner | B. Del Frari | S. Dubrac | R. Gruber | P. Pavel | D. Minzaghi | S. Blunder | C. Kremslehner | S. Oberreiter
[1] U. Wehkamp,et al. Quantitative proteomics identifies reduced NRF2 activity and mitochondrial dysfunction in Atopic Dermatitis. , 2022, The Journal of investigative dermatology.
[2] Aamir Ahmad,et al. Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance. , 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[3] C. Leprince,et al. Revisiting the Roles of Filaggrin in Atopic Dermatitis , 2022, International journal of molecular sciences.
[4] M. Cavinato,et al. Mitochondrial activity is up-regulated in nonlesional atopic dermatitis and amenable to therapeutic intervention. , 2022, The Journal of investigative dermatology.
[5] P. Elias,et al. Atopic Dermatitis: The Fate of the Fat , 2022, International journal of molecular sciences.
[6] Lisa J. Martin,et al. Longitudinal atopic dermatitis endotypes: An atopic march paradigm that includes Black children. , 2021, The Journal of allergy and clinical immunology.
[7] T. Nomura,et al. Advances in Atopic Dermatitis in 2019-2020: Endotypes from skin barrier, ethnicity, properties of antigen, cytokine profiles, microbiome, and engagement of immune cells. , 2021, The Journal of allergy and clinical immunology.
[8] K. Nakai,et al. What Are Reactive Oxygen Species, Free Radicals, and Oxidative Stress in Skin Diseases? , 2021, International journal of molecular sciences.
[9] M. P. Mori,et al. Increased H2O2 levels and p53 stabilization lead to mitochondrial dysfunction in XPC-deficient cells. , 2021, Carcinogenesis.
[10] Yingping Tian,et al. Ferroptosis: A Trigger of Proinflammatory State Progression to Immunogenicity in Necroinflammatory Disease , 2021, Frontiers in Immunology.
[11] A. Halayko,et al. Oxidized Phosphatidylcholines Induce Multiple Functional Defects in Airway Epithelial Cells. , 2021, American journal of physiology. Lung cellular and molecular physiology.
[12] M. Hermann,et al. Peroxisomal Fatty Acid Oxidation and Glycolysis Are Triggered in Mouse Models of Lesional Atopic Dermatitis , 2021, JID innovations.
[13] P. Elias,et al. Atopic dermatitis: Role of the skin barrier, environment, microbiome, and therapeutic agents. , 2021, Journal of dermatological science.
[14] F. Plou,et al. The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies , 2021, International journal of molecular sciences.
[15] J. Thyssen,et al. Biologics for Treatment of Atopic Dermatitis: Current Status and Future Prospect. , 2021, The journal of allergy and clinical immunology. In practice.
[16] D. Tang,et al. Characteristics and Biomarkers of Ferroptosis , 2021, Frontiers in Cell and Developmental Biology.
[17] J. Lee,et al. Keratinocytes-Derived Reactive Oxygen Species Play an Active Role to Induce Type 2 Inflammation of the Skin: A Pathogenic Role of Reactive Oxygen Species at the Early Phase of Atopic Dermatitis , 2020, Annals of dermatology.
[18] Y. Fujisawa,et al. NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy , 2020, The Journal of Immunology.
[19] H. Hackl,et al. First evidences of distinguishable bacterial and fungal dysbiosis in the skin of patients with Atopic Dermatitis or Netherton Syndrome. , 2020, The Journal of investigative dermatology.
[20] Å. Svensson,et al. Prevalence and Incidence of Atopic Dermatitis: A Systematic Review , 2020, Acta dermato-venereologica.
[21] M. Mildner,et al. Single-cell transcriptomics combined with interstitial fluid proteomics defines cell-type-specific immune regulation in atopic dermatitis. , 2020, The Journal of allergy and clinical immunology.
[22] G. Pioggia,et al. Oxidative Stress and Atopic Dermatitis , 2020, Antioxidants.
[23] M. Czarnecka,et al. Epidemiology of atopic dermatitis in Europe , 2019, Journal of drug assessment.
[24] C. Flohr,et al. Atopic dermatitis: the skin barrier and beyond , 2018, The British journal of dermatology.
[25] D. Mochly‐Rosen,et al. Monoamine oxidase-dependent endoplasmic reticulum-mitochondria dysfunction and mast cell degranulation lead to adverse cardiac remodeling in diabetes , 2018, Cell Death & Differentiation.
[26] D. Tuveson,et al. Transcriptional Regulation by Nrf2 , 2017, Antioxidants & redox signaling.
[27] P. Erne,et al. Pleiotropic effects of oxidized phospholipids. , 2017, Free radical biology & medicine.
[28] V. Shoshan-Barmatz,et al. VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress , 2017, Cell stress.
[29] R. Nazaryan,et al. Salivary oxidative analysis and periodontal status in children with atopy , 2017, Interventional medicine & applied science.
[30] A. Bitto,et al. Oxidative Stress: Harms and Benefits for Human Health , 2017, Oxidative medicine and cellular longevity.
[31] F. Ursini,et al. GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues. , 2017, Antioxidants & redox signaling.
[32] Thomas Bieber,et al. Clinical phenotypes and endophenotypes of atopic dermatitis: Where are we, and where should we go? , 2017, The Journal of allergy and clinical immunology.
[33] Ralph Rühl,et al. Alterations in Epidermal Eicosanoid Metabolism Contribute to Inflammation and Impaired Late Differentiation in FLG-Mutated Atopic Dermatitis. , 2017, The Journal of investigative dermatology.
[34] M. Ferracin,et al. Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B , 2017, Nature Medicine.
[35] S. Devadas,et al. Oxidative stress modulates the cytokine response of differentiated Th17 and Th1 cells. , 2016, Free radical biology & medicine.
[36] J. Silverberg,et al. Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis. , 2016, The New England journal of medicine.
[37] Xiao‐Kang Li,et al. Oxidative Stress in Atopic Dermatitis , 2016, Oxidative medicine and cellular longevity.
[38] M. Hampton,et al. Peroxiredoxins and the Regulation of Cell Death , 2016, Molecules and cells.
[39] S. Cadenas,et al. 4-Hydroxynonenal induces Nrf2-mediated UCP3 upregulation in mouse cardiomyocytes. , 2015, Free radical biology & medicine.
[40] M. Fransen,et al. Redox interplay between mitochondria and peroxisomes , 2015, Front. Cell Dev. Biol..
[41] H. Yin,et al. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria , 2014, Redox biology.
[42] P. Obexer,et al. X-Linked Inhibitor of Apoptosis Protein – A Critical Death Resistance Regulator and Therapeutic Target for Personalized Cancer Therapy , 2014, Front. Oncol..
[43] N. Chandel,et al. ROS Function in Redox Signaling and Oxidative Stress , 2014, Current Biology.
[44] Antonio Ayala,et al. Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal , 2014, Oxidative medicine and cellular longevity.
[45] S. Rutz,et al. NRROS negatively regulates reactive oxygen species during host defence and autoimmunity , 2014, Nature.
[46] S. Reddy,et al. Reactive oxygen species in inflammation and tissue injury. , 2014, Antioxidants & redox signaling.
[47] S. V. Rao,et al. Role of reactive oxygen species and antioxidants in atopic dermatitis. , 2013, Journal of clinical and diagnostic research : JCDR.
[48] C. Gieger,et al. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects , 2013, The Journal of allergy and clinical immunology.
[49] H. Okano,et al. A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis. , 2013, The Journal of allergy and clinical immunology.
[50] S. Melov,et al. SOD2 in mitochondrial dysfunction and neurodegeneration. , 2013, Free radical biology & medicine.
[51] P. Kinnunen,et al. Oxidized phosphatidylcholines in membrane‐level cellular signaling: from biophysics to physiology and molecular pathology , 2013, The FEBS journal.
[52] R. Deberardinis,et al. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development , 2013, Science Signaling.
[53] M. Murphy,et al. Mitochondrially targeted compounds and their impact on cellular bioenergetics☆ , 2013, Redox biology.
[54] Q. Ma. Role of nrf2 in oxidative stress and toxicity. , 2013, Annual review of pharmacology and toxicology.
[55] J. Lancaster,et al. Integration of cellular bioenergetics with mitochondrial quality control and autophagy , 2012, Biological chemistry.
[56] Ying Huang,et al. Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal , 2012, Cell & Bioscience.
[57] W. Sivitz,et al. Bioenergetic Effects of Mitochondrial-Targeted Coenzyme Q Analogs in Endothelial Cells , 2012, Journal of Pharmacology and Experimental Therapeutics.
[58] P. Walton,et al. Effects of Peroxisomal Catalase Inhibition on Mitochondrial Function , 2012, Front. Physio..
[59] H. Yin,et al. Free radical lipid peroxidation: mechanisms and analysis. , 2011, Chemical reviews.
[60] M. Mildner,et al. Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function. , 2011, The American journal of pathology.
[61] Y. Ho,et al. Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk , 2011, Molecular biology of the cell.
[62] Robin A. J. Smith,et al. Mitochondria-targeted antioxidants as therapies. , 2011, Discovery medicine.
[63] Ajit S. Divakaruni,et al. Mitochondrial proton and electron leaks. , 2010, Essays in biochemistry.
[64] T. Honda,et al. Molecular Pathogenesis of Genetic and Inherited Diseases Flaky Tail Mouse Denotes Human Atopic Dermatitis in the Steady State and by Topical Application with Dermatophagoides pteronyssinus Extract , 2010 .
[65] V. Darley-Usmar,et al. Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species. , 2010, Free radical biology & medicine.
[66] Luca Monticelli,et al. Effect of lipid peroxidation on the properties of lipid bilayers: a molecular dynamics study. , 2007, Biophysical journal.
[67] R. Wiesner,et al. Human epidermal keratinocytes accumulate superoxide due to low activity of Mn-SOD, leading to mitochondrial functional impairment. , 2007, The Journal of investigative dermatology.
[68] Sten Orrenius,et al. Mitochondria, oxidative stress and cell death , 2007, Apoptosis.
[69] J. Schjoerring,et al. Membrane transport of hydrogen peroxide. , 2006, Biochimica et biophysica acta.
[70] L. Davis,et al. Oxidative Stress Promotes Polarization of Human T Cell Differentiation Toward a T Helper 2 Phenotype1 , 2006, The Journal of Immunology.
[71] D. Maes,et al. Keratinocytes act as a source of reactive oxygen species by transferring hydrogen peroxide to melanocytes. , 2005, The Journal of investigative dermatology.
[72] J. Turrens,et al. Mitochondrial formation of reactive oxygen species , 2003, The Journal of physiology.
[73] H. Akamatsu,et al. Protein oxidative damage in the stratum corneum: evidence for a link between environmental oxidants and the changing prevalence and nature of atopic dermatitis in Japan , 2003, The British journal of dermatology.
[74] M. de Carli,et al. Oxidative stress stimulates IL‐4 and IL‐6 production in mast cells by an APE/Ref‐1‐dependent pathway , 2003, European journal of immunology.
[75] H. Tsukahara,et al. Increased oxidative stress in childhood atopic dermatitis. , 2001, Life sciences.
[76] J. Krueger,et al. Atopic dermatitis endotypes and implications for targeted therapeutics. , 2019, The Journal of allergy and clinical immunology.
[77] P. Reddy,et al. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer’s disease , 2018, Human molecular genetics.
[78] H. Hackl,et al. Enhanced Expression of Genes Related to Xenobiotic Metabolism in the Skin of Patients with Atopic Dermatitis but Not with Ichthyosis Vulgaris. , 2018, The Journal of investigative dermatology.
[79] P. Silveyra,et al. Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets , 2018, Pharmacology & therapeutics.
[80] W. Dröge. Free radicals in the physiological control of cell function. , 2002, Physiological reviews.