Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

[1]  E. White,et al.  Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. , 2018, Cell metabolism.

[2]  Eddy J. Bautista,et al.  Integrative Personal Omics Profiles during Periods of Weight Gain and Loss. , 2018, Cell systems.

[3]  J. Auwerx,et al.  α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis. , 2018, Journal of medicinal chemistry.

[4]  G. Prendergast,et al.  Discovery of IDO1 Inhibitors: From Bench to Bedside. , 2017, Cancer research.

[5]  Joshua D. Rabinowitz,et al.  Glucose feeds the TCA cycle via circulating lactate , 2017, Nature.

[6]  J. Rabinowitz,et al.  Chemical Basis for Deuterium Labeling of Fat and NADPH. , 2017, Journal of the American Chemical Society.

[7]  L. O’Neill,et al.  Krebs cycle rewired for macrophage and dendritic cell effector functions , 2017, FEBS letters.

[8]  J. Auwerx,et al.  Modulating NAD+ metabolism, from bench to bedside , 2017, The EMBO journal.

[9]  Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection , 2017, Scientific Reports.

[10]  Chih-Hung Chou,et al.  α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming , 2017, Nature Immunology.

[11]  Joshua D. Rabinowitz,et al.  Metabolite Spectral Accuracy on Orbitraps. , 2017, Analytical chemistry.

[12]  L. O’Neill,et al.  Mitochondria are the powerhouses of immunity , 2017, Nature Immunology.

[13]  R. Schwarcz,et al.  The kynurenine pathway and the brain: Challenges, controversies and promises , 2017, Neuropharmacology.

[14]  Ulrich Brandt,et al.  The Assembly Pathway of Mitochondrial Respiratory Chain Complex I. , 2017, Cell metabolism.

[15]  Yue Yang,et al.  NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy. , 2016, Biochimica et biophysica acta.

[16]  D. Sinclair,et al.  Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds , 2016, Nature Reviews Molecular Cell Biology.

[17]  R. Xavier,et al.  Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages , 2016, Cell.

[18]  J. Rathmell,et al.  A guide to immunometabolism for immunologists , 2016, Nature Reviews Immunology.

[19]  Maxim N. Artyomov,et al.  Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. , 2016, Cell metabolism.

[20]  H. Heller,et al.  Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice. , 2016, Brain : a journal of neurology.

[21]  J. Reid,et al.  CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. , 2016, Cell metabolism.

[22]  Monica Chagoyen,et al.  MBROLE 2.0—functional enrichment of chemical compounds , 2016, Nucleic Acids Res..

[23]  Youngjin Lee,et al.  Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis , 2016, Scientific Reports.

[24]  E. Verdin.  NAD+ in aging, metabolism, and neurodegeneration , 2015, Science.

[25]  Andrew C. Terentis,et al.  Role of indoleamine 2,3-dioxygenase in health and disease. , 2015, Clinical science.

[26]  L. O’Neill,et al.  Metabolic reprogramming in macrophages and dendritic cells in innate immunity , 2015, Cell Research.

[27]  Lihua Jiang,et al.  Optimized Analytical Procedures for the Untargeted Metabolomic Profiling of Human Urine and Plasma by Combining Hydrophilic Interaction (HILIC) and Reverse-Phase Liquid Chromatography (RPLC)–Mass Spectrometry* , 2015, Molecular & Cellular Proteomics.

[28]  Abhishek K. Jha,et al.  Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. , 2015, Immunity.

[29]  H. Brown,et al.  Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models. , 2015, The Journal of clinical investigation.

[30]  L. Guarente,et al.  NAD+ and sirtuins in aging and disease. , 2014, Trends in cell biology.

[31]  A. Chawla,et al.  Metabolic regulation of immune responses. , 2014, Annual review of immunology.

[32]  Eric A. Toth,et al.  The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid , 2013, Proteins.

[33]  R. Schwarcz,et al.  Targeted Deletion of Kynurenine 3-Monooxygenase in Mice , 2013, The Journal of Biological Chemistry.

[34]  E. Pearce,et al.  Metabolic pathways in immune cell activation and quiescence. , 2013, Immunity.

[35]  Liang Zheng,et al.  Succinate is an inflammatory signal that induces IL-1β through HIF-1α , 2013, Nature.

[36]  D. Munn,et al.  Indoleamine 2,3 dioxygenase and metabolic control of immune responses. , 2013, Trends in immunology.

[37]  Stephanie Xie,et al.  SIRT3 reverses aging-associated degeneration. , 2013, Cell reports.

[38]  M. Ziegler,et al.  The NAD metabolome — a key determinant of cancer cell biology , 2012, Nature Reviews Cancer.

[39]  Shuxing Wang,et al.  Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression. , 2012, The Journal of clinical investigation.

[40]  Alberto Mantovani,et al.  Orchestration of metabolism by macrophages. , 2012, Cell metabolism.

[41]  G. Guillemin.  Quinolinic acid, the inescapable neurotoxin , 2012, The FEBS journal.

[42]  M. Weller,et al.  An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor , 2011, Nature.

[43]  R. Schwarcz,et al.  Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration , 2011, Cell.

[44]  Janine Wehrhahn,et al.  Review: NAD + : A modulator of immune functions , 2011, Innate immunity.

[45]  L. Guarente,et al.  SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production , 2011, Oncogene.

[46]  Danica Chen,et al.  Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. , 2010, Cell metabolism.

[47]  R. Dantzer,et al.  Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice , 2009, Molecular Psychiatry.

[48]  Shiwei Song,et al.  A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis , 2008, Proceedings of the National Academy of Sciences.

[49]  James H Naismith,et al.  Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. , 2007, Journal of molecular biology.

[50]  G. Prendergast,et al.  Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. , 2007, Cancer research.

[51]  C. Brenner,et al.  NAD+ metabolism in health and disease. , 2007, Trends in biochemical sciences.

[52]  B. Baban,et al.  Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. , 2004, Journal of reproductive immunology.

[53]  N. Henderson,et al.  Blue Native electrophoresis to study mitochondrial and other protein complexes. , 2002, Methods.

[54]  T. Jernigan,et al.  Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection. , 2001, Brain : a journal of neurology.

[55]  D. Munn,et al.  Prevention of T cell–driven complement activation and inflammation by tryptophan catabolism during pregnancy , 2001, Nature Immunology.

[56]  E. Major,et al.  Human microglia convert l-tryptophan into the neurotoxin quinolinic acid. , 1992, The Biochemical journal.

[57]  M. Demitrack,et al.  Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. , 1992, Brain : a journal of neurology.

[58]  H. Schägger,et al.  Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form. , 1991, Analytical biochemistry.

[59]  D. Bender,et al.  Utilization of tryptophan, nicotinamide and nicotinic acid as precursors for nicotinamide nucleotide synthesis in isolated rat liver cells , 1988, British Journal of Nutrition.

[60]  Y. Nishizuka,et al.  STUDIES ON THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE. I. ENZYMIC SYNTHESIS OF NIACIN RIBONUCLEOTIDES FROM 3-HYDROXYANTHRANILIC ACID IN MAMMALIAN TISSUES. , 1963, The Journal of biological chemistry.