Frequency of the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene in patients with migraine with or without aura - a preliminary report.

BACKGROUND AND PURPOSE The aim of our study was to evaluate the frequency of the C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with migraine with or without aura and to find an association between this variant and vascular lesions in magnetic resonance imaging of the head, presence of patent foramen ovale (PFO) and increased level of homocysteine. MATERIAL AND METHODS Ninety-one patients with migraine, aged 19-57, were investigated in this study. The MTHFR C677T variant was genotyped in this group and levels of homocysteine, folic acid and vitamin B12 were measured. Transcranial Doppler sonography with test for PFO detection by injection of air contrast during the Valsalva manoeuvre was performed in each patient. RESULTS Frequency of the C677T variant in the MTHFR gene was similar in patients and controls. Hyperhomocysteinaemia was significantly more frequent in migraine patients with the C677T variant. The prevalence of PFO was significantly higher in migraine patients with aura and the homozygous variant of the MTHFR gene. CONCLUSIONS Frequency of the C677T variant in the MTHFR gene was similar in patients and controls. Significantly more frequent prevalence of PFO in migraine patients with aura (with homozygous recessive genotype of MTHFR probably suggests their common genetic basis. Hyperhomocysteinaemia was significantly more frequent in migraine patients with the C677T variant, which could be an additional risk factor of this disease.

[1]  L. Haupt,et al.  Analysis of the MTHFR C677T variant with migraine phenotypes , 2010, BMC Research Notes.

[2]  T. Kurth,et al.  MTHFR 677C>T and ACE D/I Polymorphisms in Migraine: A Systematic Review and Meta‐Analysis , 2010, Headache.

[3]  M. Toriello,et al.  The Relationship Between Homocysteine and Genes of Folate‐Related Enzymes in Migraine Patients , 2010, Headache.

[4]  R. Lea,et al.  The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability , 2009, Pharmacogenetics and genomics.

[5]  P. Maciel,et al.  The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal , 2008, Disease markers.

[6]  J. Ferrairó,et al.  Estudio de la relación entre lesiones de sustancia blanca en la resonancia magnética y foramen oval permeable en pacientes con migraña , 2008 .

[7]  G. Rigatelli.  Migraine and patent foramen ovale: connecting flight or one-way ticket? , 2008, Expert review of neurotherapeutics.

[8]  J. Buring,et al.  Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease , 2008, Neurology.

[9]  W. Nyka,et al.  Rola homocysteiny w patogenezie chorób układu nerwowego , 2008 .

[10]  L. Roccatagliata,et al.  White Matter Lesions in Migraine and Right-to-Left Shunt: A Conventional and Diffusion MRI Study , 2008, Cephalalgia : an international journal of headache.

[11]  R. Monastero,et al.  Migraine Mediates the Influence of C677T MTHFR Genotypes on Ischemic Stroke Risk With a Stroke-Subtype Effect , 2007, Stroke.

[12]  E. Gretchen,et al.  Migraine and Ischaemic Heart Disease and Stroke: Potential Mechanisms and Treatment Implications , 2007, Cephalalgia : an international journal of headache.

[13]  J. Swanson.  Migraine and Ischaemic Heart Disease and Stroke: Potential Mechanisms and Treatment Implications: , 2007 .

[14]  M. de Tommaso,et al.  Influence of MTHFR Genotype on Contingent Negative Variation And MRI Abnormalities in Migraine , 2007, Headache.

[15]  J. Terwilliger,et al.  Testing of Variants of the MTHFR and ESR1 Genes in 1798 Finnish Individuals Fails to Confirm the Association with Migraine with Aura , 2006, Cephalalgia : an international journal of headache.

[16]  C. Kubisch,et al.  MTHFR C677T polymorphism and migraine with aura , 2006, Annals of neurology.

[17]  E. Veneselli,et al.  Metabolic and Genetic Risk Factors for Migraine in Children , 2006, Cephalalgia : an international journal of headache.

[18]  M. Ferrari,et al.  Migraine and MTHFR C677T genotype in a population‐based sample , 2006, Annals of neurology.

[19]  A. Oterino,et al.  Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele. , 2005, Brain research. Molecular brain research.

[20]  A. Oterino,et al.  MTHFR T677 Homozygosis Influences the Presence of Aura in Migraineurs , 2004, Cephalalgia : an international journal of headache.

[21]  H. Kwiecinski,et al.  [The prevalence of patent foramen ovale in patients with migraine]. , 2004, Neurologia i neurochirurgia polska.

[22]  R. Lea,et al.  The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura , 2004, BMC medicine.

[23]  Peter J. Goadsby,et al.  A Report on the Journal 2004 , 2004 .

[24]  E. Ergul,et al.  Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. , 2003, Brain research. Molecular brain research.

[25]  N. Gadoth,et al.  Is Blood Homocysteine Elevated in Migraine? , 2001, Headache.

[26]  K. Nakashima,et al.  The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine. , 2000, American journal of medical genetics.

[27]  E. Zanette,et al.  Detection of Right-to-Left Shunt with Ultrasound Contrast Agent and Transcranial Doppler Sonography , 2000, Cerebrovascular Diseases.

[28]  H. Markus,et al.  Estimation of Cerebrovascular Reactivity Using Transcranial Doppler, Including the Use of Breath‐Holding as the Vasodilatory Stimulus , 1992, Stroke.

[29]  W. Nyka,et al.  Próba TCD na PFO - znaczenie kliniczne i ograniczenia , 2008 .

[30]  [Classification and diagnostic criteria for headache, cranial neuralgias and facial pain]. , 1993, Neurologia i neurochirurgia polska.