Chronic Prostatitis / Chronic Pelvic Pain Syndrome

Chronic prostatitis (CP) refers to "inflammation" of the prostate and is thought to be related to either an acute or chronic infection of the prostate gland. It is important to distinguish chronic prostatitis / chronic pelvic pain syndrome (CPPS) from other forms of infections of the prostate gland which include chronic bacterial prostatitis and acute bacterial prostatitis [1]. The aetiology, pathogenesis, and optimal treatment of CP/CPPS continue to be evaluated. In addition to an infective and inflammatory pathogenesis hypothesized for patients with CP/CPPS, it is important to highlight a variable degree of neuropathic pain. We present the current definition, pathogenesis and new treatment methodologies being developed to treat CP/CPPS, which continue to be a challenging clinical entity to treat worldwide by Urologist.

[1]  S. Kaplan,et al.  Long-term treatment with finasteride improves clinical progression of benign prostatic hyperplasia in men with an enlarged versus a smaller prostate: data from the MTOPS trial. , 2011, The Journal of urology.

[2]  A. Markotić,et al.  Eradication of Chlamydia trachomatis parallels symptom regression in chronic bacterial prostatitis patients treated with a fluoroquinolone–macrolide combination , 2010, Andrologia.

[3]  R. Alexander,et al.  T-cell recognition of prostatic peptides in men with chronic prostatitis/chronic pelvic pain syndrome. , 2009, The Journal of urology.

[4]  S. Chuai,et al.  Randomized multicenter feasibility trial of myofascial physical therapy for the treatment of urological chronic pelvic pain syndromes. , 2009, The Journal of urology.

[5]  Z. Galewska,et al.  The evaluation of markers of prostatic inflammation and function of the prostate gland in patients with chronic prostatitis , 2008, Archivum Immunologiae et Therapiae Experimentalis.

[6]  N. Mondaini,et al.  Introduction to chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS). , 2007, Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica.

[7]  Q. Dong,et al.  The Effect of α‐Adrenergic Antagonists in Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Meta‐Analysis of Randomized Controlled Trials , 2006 .

[8]  A. Schaeffer.  Chronic Prostatitis and the Chronic Pelvic Pain Syndrome , 2006 .

[9]  M. Pontari,et al.  How does the pre-massage and post-massage 2-glass test compare to the Meares-Stamey 4-glass test in men with chronic prostatitis/chronic pelvic pain syndrome? , 2006, The Journal of urology.

[10]  J. Turner,et al.  Stress is associated with subsequent pain and disability among men with nonbacterial prostatitis/pelvic pain , 2005, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[11]  R. Berger.  Evaluation of the cytokines interleukin 8 and epithelial neutrophil activating peptide 78 as indicators of inflammation in prostatic secretions. , 2005, The Journal of urology.

[12]  R. Berger.  Ciprofloxacin or Tamsulosin in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Randomized, Double-Blind Trial , 2005 .

[13]  G. Sant,et al.  Pentosan polysulfate sodium therapy for men with chronic pelvic pain syndrome: a multicenter, randomized, placebo controlled study. , 2005, The Journal of urology.

[14]  J. Turner,et al.  Prognosis of patients with new prostatitis/pelvic pain syndrome episodes. , 2004, The Journal of urology.

[15]  M. Pontari,et al.  A randomized placebo‐controlled multicentre study to evaluate the safety and efficacy of finasteride for male chronic pelvic pain syndrome (category IIIA chronic nonbacterial prostatitis) , 2004, BJU international.

[16]  Xu Zhang,et al.  [Clinical evaluation of celecoxib in treating type IIIA chronic prostatitis]. , 2004, Zhonghua nan ke xue = National journal of andrology.

[17]  J. Nickel,et al.  Levofloxacin for chronic prostatitis/chronic pelvic pain syndrome in men: a randomized placebo-controlled multicenter trial. , 2003, Urology.

[18]  A. Schaeffer,et al.  Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls. , 2003, The Journal of urology.

[19]  M. Ciol,et al.  Pain sensitization in male chronic pelvic pain syndrome: why are symptoms so difficult to treat? , 2003, The Journal of urology.

[20]  B. Lobel,et al.  Chronic prostatitis: what we know, what we do not know, and what we should do! , 2003, World Journal of Urology.

[21]  M. Pontari,et al.  Overview summary statement , 2002 .

[22]  M. Pontari,et al.  Leukocyte and bacterial counts do not correlate with severity of symptoms in men with chronic prostatitis: the National Institutes of Health Chronic Prostatitis Cohort Study. , 2002, The Journal of urology.

[23]  M. Barry,et al.  Prevalence and correlates of prostatitis in the health professionals follow-up study cohort. , 2002, The Journal of urology.

[24]  M. Litt,et al.  Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome. , 2002, The Journal of urology.

[25]  R. Nadler,et al.  Laparoscopic excision of a seminal vesicle for the chronic pelvic pain syndrome. , 2001, The Journal of urology.

[26]  J. Nickel,et al.  Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health chronic prostatitis symptom index. , 2001, The Journal of urology.

[27]  R. Roberts,et al.  Epidemiology of Prostatitis , 2000, Current urology reports.

[28]  P. Yarnold,et al.  IL-1β AND TNF-α IN PROSTATIC SECRETIONS ARE INDICATORS IN THE EVALUATION OF MEN WITH CHRONIC PROSTATITIS , 2000 .

[29]  L. True,et al.  Prostate histopathology and the chronic prostatitis/chronic pelvic pain syndrome: a prospective biopsy study. , 2000, The Journal of urology.

[30]  M. Pontari,et al.  The National Institutes of Health chronic prostatitis symptom index: Development and validation of a new outcome measure , 1999 .

[31]  J. Krieger,et al.  NIH consensus definition and classification of prostatitis. , 1999, JAMA.

[32]  J. Nickel.  Effective office management of chronic prostatitis. , 1998, The Urologic clinics of North America.

[33]  M. Barry,et al.  How common is prostatitis? A national survey of physician visits. , 1998, The Journal of urology.

[34]  K. Egan,et al.  Chronic Abacterial Prostatitis-A Urological Chronic Pain Syndrome? , 1998 .

[35]  R. Alexander,et al.  Autoimmune prostatitis: evidence of T cell reactivity with normal prostatic proteins. , 1997, Urology.

[36]  J. Krieger,et al.  Bacteria in the prostate tissue of men with idiopathic prostatic inflammation. , 1997, The Journal of urology.

[37]  J. Heiman,et al.  Sickness impact of chronic nonbacterial prostatitis and its correlates. , 1996, The Journal of urology.

[38]  S. Kaplan,et al.  Urodynamic evidence of vesical neck obstruction in men with misdiagnosed chronic nonbacterial prostatitis and the therapeutic role of endoscopic incision of the bladder neck. , 1994, The Journal of urology.

[39]  J. J. de la Rosette,et al.  Diagnosis and treatment of 409 patients with prostatitis syndromes. , 1993, Urology.

[40]  M. Barry,et al.  The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association. , 1992, The Journal of urology.

[41]  A. Reiss,et al.  Syndrome , 1990, Biological Psychiatry.

[42]  R. Kirby,et al.  Intra-prostatic urinary reflux: an aetiological factor in abacterial prostatitis. , 1982, British journal of urology.

[43]  J. Kavanagh,et al.  The response of seven prostatic fluid components to prostatic disease. , 1982, International journal of andrology.

[44]  R. Barnard,et al.  Prostatodynia--physiological characteristics and rational management with muscle relaxants. , 1981, British journal of urology.

[45]  T. Stamey.  Periurethral or perineal bacteria in urinary tract infections? , 1981, JAMA.

[46]  S. Colleen,et al.  Role of Chlamydia trachomatis in non-acute prostatitis. , 1978, The British journal of venereal diseases.

[47]  N. Blacklock.  Anatomical factors in prostatitis. , 1974, British journal of urology.

[48]  T. Stamey,et al.  Bacteriologic localization patterns in bacterial prostatitis and urethritis. , 1968, Investigative urology.

[49]  A. Sarma,et al.  Prevalence of and risk factors for prostatitis in African American men: The Flint Men's Health Study , 2009, The Prostate.

[50]  R. Vaidyanathan,et al.  Chronic prostatitis: Current concepts , 2008, Indian journal of urology : IJU : journal of the Urological Society of India.

[51]  A. Schaeffer.  Clinical practice. Chronic prostatitis and the chronic pelvic pain syndrome. , 2006, The New England journal of medicine.

[52]  Q. Dong,et al.  The effect of alpha-adrenergic antagonists in chronic prostatitis/chronic pelvic pain syndrome: a meta-analysis of randomized controlled trials. , 2006, Journal of andrology.

[53]  T. Cooper,et al.  The evaluation of markers of prostatic function , 2004, Urological Research.

[54]  T. Wilt,et al.  Diagnosis and treatment of chronic abacterial prostatitis: a systematic review. , 2000, Annals of internal medicine.

[55]  P. Yarnold,et al.  IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis. , 2000, The Journal of urology.

[56]  D. Bostwick,et al.  Prevalence of a physician-assigned diagnosis of prostatitis: the Olmsted County Study of Urinary Symptoms and Health Status Among Men. , 1998, Urology.

[57]  J. Nickel.  The Pre and Post Massage Test (PPMT): a simple screen for prostatitis. , 1997, Techniques in urology.

[58]  Nickel Jc.  The Pre and Post Massage Test (PPMT): a simple screen for prostatitis. , 1997 .

[59]  J. Nickel,et al.  Bacterial localization in antibiotic‐refractory chronic bacterial prostatitis , 1993, The Prostate.