SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells

[1]  N. Brockdorff.  Polycomb complexes in X chromosome inactivation , 2017, Philosophical Transactions of the Royal Society B: Biological Sciences.

[2]  Kyunghee Choi,et al.  A CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment , 2017, Nature Communications.

[3]  J. Marioni,et al.  Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation , 2017, Cell reports.

[4]  C. Porcher,et al.  SCL/TAL1: a multifaceted regulator from blood development to disease. , 2017, Blood.

[5]  Chunhui Hou,et al.  RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions. , 2017, Cell stem cell.

[6]  M. Vidal,et al.  Polycomb complexes PRC1 and their function in hematopoiesis. , 2017, Experimental hematology.

[7]  R. Sandberg,et al.  Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo , 2017, eLife.

[8]  Nicola K. Wilson,et al.  Resolving Early Mesoderm Diversification through Single Cell Expression Profiling , 2016, Nature.

[9]  V. Kouskoff,et al.  The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development , 2016, Cell reports.

[10]  A. Iwama,et al.  Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells , 2016, PloS one.

[11]  W. V. van IJcken,et al.  Control of developmentally primed erythroid genes by combinatorial co-repressor actions , 2015, Nature Communications.

[12]  R. Klose,et al.  Targeting Polycomb systems to regulate gene expression: modifications to a complex story , 2015, Nature Reviews Molecular Cell Biology.

[13]  M. Pellegrini,et al.  Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence , 2015, The EMBO journal.

[14]  David A. Orlando,et al.  Quantitative ChIP-Seq normalization reveals global modulation of the epigenome. , 2014, Cell reports.

[15]  E. Robertson.  Dose-dependent Nodal/Smad signals pattern the early mouse embryo. , 2014, Seminars in cell & developmental biology.

[16]  R. Stewart,et al.  Pax3 and Tbx5 Specify Whether PDGFRα+ Cells Assume Skeletal or Cardiac Muscle Fate in Differentiating Embryonic Stem Cells , 2014, Stem cells.

[17]  Stephen Taylor,et al.  MIG: Multi-Image Genome viewer , 2013, Bioinform..

[18]  J. Nichols,et al.  A molecular basis for developmental plasticity in early mammalian embryos , 2013, Development.

[19]  A. Oudenaarden,et al.  Single-molecule mRNA detection and counting in mammalian tissue , 2013, Nature Protocols.

[20]  M. Hendzel,et al.  A Small Molecule Inhibitor of Polycomb Repressive Complex 1 Inhibits Ubiquitin Signaling at DNA Double-strand Breaks* , 2013, The Journal of Biological Chemistry.

[21]  Anushya Muruganujan,et al.  Large-scale gene function analysis with the PANTHER classification system , 2013, Nature Protocols.

[22]  E. Mancini,et al.  Structural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets , 2013, Cell reports.

[23]  Bruno Di Stefano,et al.  Polycomb complexes in stem cells and embryonic development , 2013, Development.

[24]  Daniel J Garry,et al.  Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner. , 2013, Cell Stem Cell.

[25]  Cole Trapnell,et al.  TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions , 2013, Genome Biology.

[26]  K. Hahn,et al.  An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. , 2013, ACS chemical biology.

[27]  B. Hendrich,et al.  Transcriptional repressors: multifaceted regulators of gene expression , 2013, Development.

[28]  L. Cozzuto,et al.  RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells. , 2013, Cell reports.

[29]  M. Pellegrini,et al.  Scl Represses Cardiomyogenesis in Prospective Hemogenic Endothelium and Endocardium , 2012, Cell.

[30]  N. Brockdorff,et al.  RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3 , 2012, Cell.

[31]  Yuval Kluger,et al.  PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. , 2012, Molecular cell.

[32]  Davis J. McCarthy,et al.  Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation , 2012, Nucleic acids research.

[33]  M. Vidal,et al.  RYBP Represses Endogenous Retroviruses and Preimplantation- and Germ Line-Specific Genes in Mouse Embryonic Stem Cells , 2012, Molecular and Cellular Biology.

[34]  Jennifer Nichols,et al.  Differential plasticity of epiblast and primitive endoderm precursors within the ICM of the early mouse embryo , 2012, Development.

[35]  Gordon Keller,et al.  Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. , 2011, Cell stem cell.

[36]  C. Blanpain,et al.  Mesp1: A Key Regulator of Cardiovascular Lineage Commitment , 2010, Circulation research.

[37]  Shamit Soneji,et al.  Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells. , 2010, Genome research.

[38]  Cory Y. McLean,et al.  GREAT improves functional interpretation of cis-regulatory regions , 2010, Nature Biotechnology.

[39]  M. Robinson,et al.  A scaling normalization method for differential expression analysis of RNA-seq data , 2010, Genome Biology.

[40]  G. Daley,et al.  Mesodermal patterning activity of SCL. , 2008, Experimental hematology.

[41]  P. Vyas,et al.  Characterization of megakaryocyte GATA1-interacting proteins: the corepressor ETO2 and GATA1 interact to regulate terminal megakaryocyte maturation. , 2008, Blood.

[42]  P. Vyas,et al.  Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis. , 2008, Blood.

[43]  B. Göttgens,et al.  The SCL +40 Enhancer Targets the Midbrain Together with Primitive and Definitive Hematopoiesis and Is Regulated by SCL and GATA Proteins , 2007, Molecular and Cellular Biology.

[44]  D. Yelon,et al.  Vessel and blood specification override cardiac potential in anterior mesoderm. , 2007, Developmental cell.

[45]  M. Barna,et al.  Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes. , 2007, Developmental cell.

[46]  S. Nishikawa,et al.  In Vitro Modeling of Paraxial and Lateral Mesoderm Differentiation Reveals Early Reversibility , 2006, Stem cells.

[47]  P. Vyas,et al.  ETO-2 Associates with SCL in Erythroid Cells and Megakaryocytes and Provides Repressor Functions in Erythropoiesis , 2005, Molecular and Cellular Biology.

[48]  S. Nishikawa,et al.  Involvement of Runx1 in the down-regulation of fetal liver kinase-1 expression during transition of endothelial cells to hematopoietic cells. , 2005, Blood.

[49]  A. Elefanty,et al.  SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development. , 2005, Blood.

[50]  S. Orkin,et al.  Decoding Hematopoietic Specificity in the Helix-Loop-Helix Domain of the Transcription Factor SCL/Tal-1 , 2004, Molecular and Cellular Biology.

[51]  T. Rabbitts,et al.  Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1 , 2003, Development.

[52]  Patrick W. Faloon,et al.  Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. , 2003, Genes & development.

[53]  Marie-Christine Chaboissier,et al.  The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. , 2002, Genes & development.

[54]  A. Nagy,et al.  The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo. , 1999, Development.

[55]  R. Stein,et al.  p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein , 1999, Oncogene.

[56]  A. Eichmann,et al.  Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny. , 1998, Development.

[57]  S. Nishikawa,et al.  Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages. , 1998, Development.

[58]  Virginia E. Papaioannou,et al.  Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6 , 1998, Nature.

[59]  Janet Rossant,et al.  A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis , 1997, Cell.

[60]  P. Tam,et al.  The allocation of epiblast cells to the embryonic heart and other mesodermal lineages: the role of ingression and tissue movement during gastrulation. , 1997, Development.

[61]  T. Magnuson,et al.  MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation. , 1996, Development.

[62]  F. Alt,et al.  The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic Lineages , 1996, Cell.

[63]  S. Orkin,et al.  Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL , 1995, Nature.

[64]  R. Pedersen,et al.  Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. , 1991, Development.

[65]  M. Schneider.  A Key Regulator of Cardiovascular Lineage Commitment , 2010 .

[66]  Elizabeth J. Robertson,et al.  Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo , 2009, Nature Reviews Molecular Cell Biology.

[67]  G. Keller.  Embryonic stem cell differentiation : emergence of a new era in biology and medicine , 2005 .