A mechanistic overview of translation initiation in eukaryotes

[1]  A. Hinnebusch,et al.  Specific Domains in Yeast Translation Initiation Factor eIF4G Strongly Bias RNA Unwinding Activity of the eIF4F Complex toward Duplexes with 5′-Overhangs* , 2012, The Journal of Biological Chemistry.

[2]  M. Sachs,et al.  Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5 , 2011, Nucleic acids research.

[3]  Ji-Chun Yang,et al.  Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly , 2011, Nucleic acids research.

[4]  C. Fraser,et al.  The human translation initiation multi-factor complex promotes methionyl-tRNAi binding to the 40S ribosomal subunit , 2011, Nucleic acids research.

[5]  Sergey Melnikov,et al.  The Structure of the Eukaryotic Ribosome at 3.0 Å Resolution , 2011, Science.

[6]  C. Fraser,et al.  Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B. , 2011, Journal of molecular biology.

[7]  A. Hinnebusch,et al.  Functional Elements in Initiation Factors 1, 1A, and 2β Discriminate against Poor AUG Context and Non-AUG Start Codons , 2011, Molecular and Cellular Biology.

[8]  A. Hinnebusch,et al.  Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes , 2011, Microbiology and Molecular Reviews.

[9]  Tao You,et al.  Analysing GCN4 translational control in yeast by stochastic chemical kinetics modelling and simulation , 2011, BMC Systems Biology.

[10]  Sarah E. Walker,et al.  Initiation Factor eIF2γ Promotes eIF2–GTP–Met-tRNAiMet Ternary Complex Binding to the 40S Ribosome , 2011, Nature Structural &Molecular Biology.

[11]  A. Spirin,et al.  Unidirectional constant rate motion of the ribosomal scanning particle during eukaryotic translation initiation , 2011, Nucleic acids research.

[12]  N. Ban,et al.  Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1 , 2011, Science.

[13]  Sarah E. Walker,et al.  Multiple elements in the eIF4G1 N‐terminus promote assembly of eIF4G1•PABP mRNPs in vivo , 2011, The EMBO journal.

[14]  C. Hellen,et al.  Bypassing of stems versus linear base‐by‐base inspection of mammalian mRNAs during ribosomal scanning , 2011, The EMBO journal.

[15]  S. Hoffmann,et al.  Synergistic activation of eIF4A by eIF4B and eIF4G , 2010, Nucleic acids research.

[16]  D. Klostermeier,et al.  eIF4G stimulates the activity of the DEAD box protein eIF4A by a conformational guidance mechanism , 2010, Nucleic acids research.

[17]  Sergey V. Melnikov,et al.  The structure of the eukaryotic ribosome at 3.0 angstrom resolution. , 2011 .

[18]  A. Hinnebusch,et al.  Depletion of eIF4G from yeast cells narrows the range of translational efficiencies genome-wide , 2011, BMC Genomics.

[19]  M. Sachs,et al.  Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1) , 2010, Proceedings of the National Academy of Sciences.

[20]  G. Coghill,et al.  A quantitative model for mRNA translation in Saccharomyces cerevisiae , 2010, Yeast.

[21]  Sarah E. Walker,et al.  The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway. , 2010, Molecular cell.

[22]  Y. Mechulam,et al.  tRNA binding properties of eukaryotic translation initiation factor 2 from Encephalitozoon cuniculi. , 2010, Biochemistry.

[23]  L. Valášek,et al.  The RNA Recognition Motif of Eukaryotic Translation Initiation Factor 3g (eIF3g) Is Required for Resumption of Scanning of Posttermination Ribosomes for Reinitiation on GCN4 and Together with eIF3i Stimulates Linear Scanning , 2010, Molecular and Cellular Biology.

[24]  A. Hinnebusch,et al.  The C-Terminal Region of Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes mRNA Recruitment, Scanning, and, Together with eIF3j and the eIF3b RNA Recognition Motif, Selection of AUG Start Codons , 2010, Molecular and Cellular Biology.

[25]  K. Asano,et al.  The Eukaryotic Initiation Factor (eIF) 4G HEAT Domain Promotes Translation Re-initiation in Yeast Both Dependent on and Independent of eIF4A mRNA Helicase* , 2010, The Journal of Biological Chemistry.

[26]  R. Jackson,et al.  The mechanism of eukaryotic translation initiation and principles of its regulation , 2010, Nature Reviews Molecular Cell Biology.

[27]  J. Lorsch,et al.  Eukaryotic initiator tRNA: Finely tuned and ready for action , 2010, FEBS letters.

[28]  L. Valášek,et al.  The indispensable N-terminal half of eIF3j/HCR1 co-operates with its structurally conserved binding partner eIF3b/PRT1-RRM and eIF1A in stringent AUG selection , 2010, Journal of molecular biology.

[29]  A. Hinnebusch,et al.  Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome. , 2010, Genes & development.

[30]  A. Hinnebusch,et al.  eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation. , 2009, Journal of molecular biology.

[31]  A. Spirin.  How does a scanning ribosomal particle move along the 5'-untranslated region of eukaryotic mRNA? Brownian Ratchet model. , 2009, Biochemistry.

[32]  G. Wagner,et al.  Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing , 2009, Nucleic acids research.

[33]  Michael D. Dennis,et al.  Evidence for Variation in the Optimal Translation Initiation Complex: Plant eIF4B, eIF4F, and eIF(iso)4F Differentially Promote Translation of mRNAs1[OA] , 2009, Plant Physiology.

[34]  W. Merrick,et al.  Intrinsic RNA Binding by the Eukaryotic Initiation Factor 4F Depends on a Minimal RNA Length but Not on the m7G Cap* , 2009, The Journal of Biological Chemistry.

[35]  A. Hinnebusch,et al.  Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets , 2009, Cell.

[36]  N. Sonenberg,et al.  Topology and Regulation of the Human eIF4A/4G/4H Helicase Complex in Translation Initiation , 2009, Cell.

[37]  J. Lorsch,et al.  Kinetic analysis of late steps of eukaryotic translation initiation. , 2009, Journal of molecular biology.

[38]  N. Sonenberg,et al.  General RNA‐binding proteins have a function in poly(A)‐binding protein‐dependent translation , 2009, The EMBO journal.

[39]  N. Sonenberg,et al.  Requirement of RNA Binding of Mammalian Eukaryotic Translation Initiation Factor 4GI (eIF4GI) for Efficient Interaction of eIF4E with the mRNA Cap , 2008, Molecular and Cellular Biology.

[40]  D. Goss,et al.  Translation Initiation Factor 4B Homodimerization, RNA Binding, and Interaction with Poly(A)-binding Protein Are Enhanced by Zinc* , 2008, Journal of Biological Chemistry.

[41]  A. Komar,et al.  Translation Initiation on Mammalian mRNAs with Structured 5′UTRs Requires DExH-Box Protein DHX29 , 2008, Cell.

[42]  Fei Liu,et al.  ATP hydrolysis is required for DEAD-box protein recycling but not for duplex unwinding , 2008, Proceedings of the National Academy of Sciences.

[43]  M. Moore,et al.  Interactions between eIF4AI and its accessory factors eIF4B and eIF4H. , 2008, RNA.

[44]  A. Hinnebusch,et al.  eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA. , 2008, Genes & development.

[45]  M. Yusupov,et al.  Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes , 2008, The EMBO journal.

[46]  J. Pelletier,et al.  Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking. , 2008, RNA.

[47]  J. Zavadil,et al.  eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy , 2008, The Journal of cell biology.

[48]  R. E. Luna,et al.  Eukaryotic Initiation Factor (eIF) 1 Carries Two Distinct eIF5-binding Faces Important for Multifactor Assembly and AUG Selection* , 2008, Journal of Biological Chemistry.

[49]  R. Jackson,et al.  The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation. , 2007, Genes & development.

[50]  Mikkel A. Algire,et al.  Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo. , 2007, Genes & development.

[51]  Mikkel A. Algire,et al.  The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome. , 2007, Molecular cell.

[52]  Jon R Lorsch,et al.  N‐ and C‐terminal residues of eIF1A have opposing effects on the fidelity of start codon selection , 2007, The EMBO journal.

[53]  V. M. Pain,et al.  Functional Analysis of Individual Binding Activities of the Scaffold Protein eIF4G* , 2007, Journal of Biological Chemistry.

[54]  Alan G Hinnebusch,et al.  eIF3: a versatile scaffold for translation initiation complexes. , 2006, Trends in biochemical sciences.

[55]  T. E. Dever,et al.  Direct Binding of Translation Initiation Factor eIF2γ-G Domain to Its GTPase-activating and GDP-GTP Exchange Factors eIF5 and eIF2Bϵ* , 2006, Journal of Biological Chemistry.

[56]  O. Nureki,et al.  Structural Basis for RNA Unwinding by the DEAD-Box Protein Drosophila Vasa , 2006, Cell.

[57]  A. Hinnebusch,et al.  Interaction of the RNP1 Motif in PRT1 with HCR1 Promotes 40S Binding of Eukaryotic Initiation Factor 3 in Yeast , 2006, Molecular and Cellular Biology.

[58]  J. Lorsch,et al.  Interaction between Eukaryotic Initiation Factors 1A and 5B Is Required for Efficient Ribosomal Subunit Joining* , 2006, Journal of Biological Chemistry.

[59]  Aaron K. LeFebvre,et al.  Translation Initiation Factor eIF4G-1 Binds to eIF3 through the eIF3e Subunit* , 2006, Journal of Biological Chemistry.

[60]  C. Hellen,et al.  Specific functional interactions of nucleotides at key -3 and +4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complex. , 2006, Genes & development.

[61]  Mikkel A. Algire,et al.  Communication between eukaryotic translation initiation factors 5 and 1A within the ribosomal pre-initiation complex plays a role in start site selection. , 2006, Journal of molecular biology.

[62]  A. Hinnebusch,et al.  Eukaryotic Translation Initiation Factor 3 (eIF3) and eIF2 Can Promote mRNA Binding to 40S Subunits Independently of eIF4G in Yeast , 2006, Molecular and Cellular Biology.

[63]  E. Nogales,et al.  Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis , 2005, Science.

[64]  Yasufumi Yamamoto,et al.  The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4G. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[65]  Mikkel A. Algire,et al.  Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation. , 2005, Molecular cell.

[66]  G. Wagner,et al.  Structural basis for the enhancement of eIF4A helicase activity by eIF4G. , 2005, Genes & development.

[67]  Katsura Asano,et al.  Eukaryotic Translation Initiation Factor 5 Is Critical for Integrity of the Scanning Preinitiation Complex and Accurate Control of GCN4 Translation , 2005, Molecular and Cellular Biology.

[68]  C. Hellen,et al.  Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association. , 2005, RNA.

[69]  J. Lorsch,et al.  A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codon. , 2005, Molecular cell.

[70]  N. Sonenberg,et al.  Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. , 2005, Genes & development.

[71]  C. Hellen,et al.  Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of eIF2-bound GTP. , 2004, Genes & development.

[72]  A. Hinnebusch,et al.  Interactions of Eukaryotic Translation Initiation Factor 3 (eIF3) Subunit NIP1/c with eIF1 and eIF5 Promote Preinitiation Complex Assembly and Regulate Start Codon Selection , 2004, Molecular and Cellular Biology.

[73]  Yasufumi Yamamoto,et al.  Efficient Incorporation of Eukaryotic Initiation Factor 1 into the Multifactor Complex Is Critical for Formation of Functional Ribosomal Preinitiation Complexes in Vivo* , 2004, Journal of Biological Chemistry.

[74]  A. Hinnebusch,et al.  Functions of eIF3 downstream of 48S assembly impact AUG recognition and GCN4 translational control , 2004, The EMBO journal.

[75]  Mark Muldoon,et al.  Dynamics and processivity of 40S ribosome scanning on mRNA in yeast , 2004, Molecular microbiology.

[76]  Jon R Lorsch,et al.  GTP-dependent recognition of the methionine moiety on initiator tRNA by translation factor eIF2. , 2004, Journal of molecular biology.

[77]  W. Merrick,et al.  Assembly of 48S Translation Initiation Complexesfrom Purified Components with mRNAs That Have Some Base Pairingwithin Their 5′ UntranslatedRegions , 2003, Molecular and Cellular Biology.

[78]  G. Wagner,et al.  Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing. , 2003, Genes & development.

[79]  J. Lorsch,et al.  Communication between eukaryotic translation initiation factors 1 and 1A on the yeast small ribosomal subunit. , 2003, Journal of molecular biology.

[80]  J. Garin,et al.  Characterization of a novel RNA‐binding region of eIF4GI critical for ribosomal scanning , 2003, The EMBO journal.

[81]  A. Hinnebusch,et al.  The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo. , 2003, Genes & development.

[82]  U. Maitra,et al.  Mammalian Translation Initiation Factor eIF1 Functions with eIF1A and eIF3 in the Formation of a Stable 40 S Preinitiation Complex* , 2003, The Journal of Biological Chemistry.

[83]  G. Wagner,et al.  Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: A new interaction between old partners , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[84]  A. Hinnebusch,et al.  Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo , 2003, The EMBO journal.

[85]  N. Sonenberg,et al.  A Novel Role of the Mammalian GSPT/eRF3 Associating with Poly(A)-binding Protein in Cap/Poly(A)-dependent Translation* , 2002, The Journal of Biological Chemistry.

[86]  S. Burley,et al.  Uncoupling of Initiation Factor eIF5B/IF2 GTPase and Translational Activities by Mutations that Lower Ribosome Affinity , 2002, Cell.

[87]  T. Pestova,et al.  The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. , 2002, Genes & development.

[88]  A. Hinnebusch,et al.  Direct eIF2–eIF3 contact in the multifactor complex is important for translation initiation in vivo , 2002, The EMBO journal.

[89]  J. McCarthy,et al.  Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap‐complex function , 2002, Molecular microbiology.

[90]  Mikkel A. Algire,et al.  Development and characterization of a reconstituted yeast translation initiation system. , 2002, RNA.

[91]  C. Gissi,et al.  Untranslated regions of mRNAs , 2002, Genome Biology.

[92]  W. Merrick,et al.  Modulation of the Helicase Activity of eIF4A by eIF4B, eIF4H, and eIF4F* , 2001, The Journal of Biological Chemistry.

[93]  R. Pincheira,et al.  Two subcellular localizations of eIF3 p170 and its interaction with membrane-bound microfilaments: implications for alternative functions of p170. , 2001, European journal of cell biology.

[94]  A. Hinnebusch,et al.  Multiple roles for the C‐terminal domain of eIF5 in translation initiation complex assembly and GTPase activation , 2001, The EMBO journal.

[95]  H. Ruis,et al.  Rpg1p/Tif32p, a subunit of translation initiation factor 3, interacts with actin-associated protein Sla2p. , 2001, Biochemical and Biophysical Research Communications - BBRC.

[96]  R. Ghosh,et al.  Eukaryotic Translation Initiation Factor 5 Functions as a GTPase-activating Protein* , 2001, The Journal of Biological Chemistry.

[97]  C. Proud,et al.  Eukaryotic translation initiation factor 5 (eIF5) acts as a classical GTPase-activator protein , 2001, Current Biology.

[98]  A. Hinnebusch,et al.  A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo. , 2000, Genes & development.

[99]  J. Ren,et al.  Wheat germ translation initiation factor eIF4B affects eIF4A and eIFiso4F helicase activity by increasing the ATP binding affinity of eIF4A. , 2000, Biochemistry.

[100]  S. Kohlwein,et al.  Rpg1p, the subunit of the Saccharomyces cerevisiae eIF3 core complex, is a microtubule-interacting protein. , 2000, Cell motility and the cytoskeleton.

[101]  C. Hellen,et al.  The joining of ribosomal subunits in eukaryotes requires eIF5B , 2000, Nature.

[102]  J. Chaudhuri,et al.  Distinct Functions of Eukaryotic Translation Initiation Factors eIF1A and eIF3 in the Formation of the 40 S Ribosomal Preinitiation Complex* , 1999, The Journal of Biological Chemistry.

[103]  A. Hinnebusch,et al.  Conserved bipartite motifs in yeast eIF5 and eIF2Bϵ, GTPase‐activating and GDP–GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2 , 1999, The EMBO journal.

[104]  H. Trachsel,et al.  The RNA recognition motif of yeast translation initiation factor Tif3/eIF4B is required but not sufficient for RNA strand-exchange and translational activity. , 1998, RNA.

[105]  C. Hellen,et al.  Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons , 1998, Nature.

[106]  D. Herschlag,et al.  The DEAD box protein eIF4A. 1. A minimal kinetic and thermodynamic framework reveals coupled binding of RNA and nucleotide. , 1998, Biochemistry.

[107]  A. Sachs,et al.  Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[108]  N. Sonenberg,et al.  A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3 , 1996, Molecular and cellular biology.

[109]  N. Sonenberg,et al.  The Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homologue, eIF‐4B, have RNA annealing activity. , 1995, The EMBO journal.